Results 141 to 150 of about 78,155 (186)

Distinct profiles of LRRK2 activation and Rab GTPase phosphorylation in clinical samples from different PD cohorts. [PDF]

NPJ Parkinsons Dis, 2022
Petropoulou-Vathi L, Simitsi A, Valkimadi PE, Kedariti M, Dimitrakopoulos L, Koros C, Papadimitriou D, Papadimitriou A, Stefanis L, Alcalay RN, Rideout HJ.   +10 more
europepmc   +1 more source

A Small-Scale shRNA Screen in Primary Mouse Macrophages Identifies a Role for the Rab GTPase Rab1b in Controlling Salmonella Typhi Growth. [PDF]

Front Cell Infect Microbiol, 2021
Solano-Collado V, Colamarino RA, Calderwood DA, Baldassarre M, Spanò S.   +4 more
europepmc   +1 more source

A RabGAP-Rab GTPase pair regulates plant autophagy and immunity

, 2023
Yuen ELH, Leary AY, Clavel M, Tumtas Y, Mohseni A, Picchianti L, Jamshidiha M, Pandey P, Duggan C, Cota E, Dagdas Y, Bozkurt TO.   +11 more
europepmc   +1 more source

Purification and identification of novel Rab effectors using affinity chromatography

, 2000
Rab GTPases are central regulatory elements of the intracellular transport machinery of eukaryotic cells. To regulate vesicle docking and fusion as well as organelle dynamics Rab proteins interact with effector molecules in the GTP-bound active state ...
Zerial, M., Christoforidis, S.
core  

The LRRK2 G2019S variant rewires Rab GTPase phosphorylation after lysosomal damage and promotes cell death in human macrophages. [PDF]

J Cell Sci
Morrison R, Mihaylov SR, Luk CH, Lemerle C, Rodgers A, Athanasiadi N, Morris HR, Pellegrino E, Ultanir SK, Gutierrez MG.   +9 more
europepmc   +1 more source

Identification of Regulators of the Rab GTPase Ypt11 Involved in Mitochondrial Inheritance

, 2017
Eukaryotic cells possess a variety of membrane-bound organelles that house specific biochemical functions essential to maintaining cellular health. Membrane fusion events and transport of entire organelles are regulated by molecular switch proteins ...
Ramos, Christopher
core   +1 more source

TBC-2, a Rab GTPase activating protein, regulates the localization of the HLH-30/TFEB and PQM-1 transcription factors in the <i>C. elegans</i> intestine. [PDF]

MicroPubl Biol
Saha S, Meras I, Rocheleau CE.
europepmc   +1 more source

The DENN Protein SMD1 Forms a Signalling Hub With Rab GTPase YPT1 to Regulate Diverse Biological Processes in Phytopathogenic Fungi and Serves as a HIGS Target for Crop Protection. [PDF]

Mol Plant Pathol
Zhang C, Li L, Liu S, Xu Y, Li X, Zhang Y.   +5 more
europepmc   +1 more source

Endosome maturation is orchestrated by inside-out proton signaling through a Na⁺/H⁺ exchanger and pH-dependent Rab GTPase cycling. [PDF]

Nat Commun
Lee Y, Ouyang Q, Ma L, Fleishman M, Riaz HA, Schmidt M, Dupree JL, Mondal A, Mohanty P, Mittal J, Beckstein O, Lambright DG, Morrow EM.   +12 more
europepmc   +1 more source

Stochastic activation and bistability in a Rab GTPase regulatory network. [PDF]

Proc Natl Acad Sci U S A, 2020
Bezeljak U, Loya H, Kaczmarek B, Saunders TE, Loose M.   +4 more
europepmc   +1 more source