Results 51 to 60 of about 3,667 (257)
Multi‐omics profiling reveals key factors involved in Ewing sarcoma metastasis
Molecular Oncology, EarlyView.Using a mouse model that recapitulates the spread of tumor cells within the body, we have profiled paired tumors and metastasis samples using a multiomics approach combining different layers of biological information. We identified key genes that drive metastasis in Ewing sarcoma.
Mariona Chicón‐Bosch +11 more
wiley +1 more source
Innate immune receptor NOD2 mediates LGR5+ intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation [PDF]
, 2020 International audienceThe nucleotide-binding oligomerization domain-containing protein 2 (NOD2) agonist muramyl dipeptide (MDP), a peptidoglycan motif common to all bacteria, supports leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5 ...
Deutsch, Eric +6 more
core +3 more sources
Molecular Oncology, EarlyView.Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti +8 more
wiley +1 more source
Lewis Carrol and Iris Murdoch: dialigue after a century [PDF]
, 2013 The article dwells upon influences of L.Carroll’s Alice in Wonderland in Iris Murdoch’s early novel The Flight from the Enchanter. The analysis is conducted in the terms of inheritance and contradiction with the traditional classical 19th c ...
Isakova, M.L.
core
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source
Molecular Oncology, EarlyView.NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi +5 more
wiley +1 more source
Vulnerability Analysis of the MAVLink Protocol for Command and Control of Unmanned Aircraft [PDF]
, 2014 The MAVLink protocol is an open source, point-to-point networking protocol used to carry telemetry and to command and control many small unmanned aircraft. This research presents three exploits that compromise confidentiality, integrity, and availability
Marty, Joseph A.
core +1 more source
Molecular Oncology, EarlyView.The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh +6 more
wiley +1 more source
, 2015 Science/Fiction lays out the philosophical and personal underpinnings of the homonymous exhibition. The works shown are driven by an engagement with source materials ranging from the film, The Trial, to the experience of complexity and exclusion as it ...
Adams, Nicholas
core +3 more sources
COZMO-A New Lightweight Stream Cipher [PDF]
, 2018 This paper deals with the merger of the two lightweight stream ciphers: A5by1 and Trivium. The idea is to make the key stream generation more secure and to remove the attacks of the individual algorithms. The bits generated by the Trivium cipher will act as the input of the A5by1 cipher.
arxiv +1 more source