Results 171 to 180 of about 162,658 (282)

Stroke‐Homing Peptide‐DNase1 Alleviates Intestinal Ischemia Reperfusion Injury by Selectively Degrading Neutrophil Extracellular Traps

open access: yesCell Proliferation, EarlyView.
SHp‐DNase1 combined with CRO inhibits NETs to alleviate intestinal IRI ABSTRACT Neutrophil extracellular traps (NETs) act as a vital first line of defence against tissue damage and pathogens, playing a significant role in improving diseases such as intestinal ischemia reperfusion injury (IRI).
Tingting Liu   +12 more
wiley   +1 more source

KYNA Ameliorates Hepatic Ischemia–Reperfusion Injury by Activating the Hippo Signalling Pathway via FTO‐Dependent m6A Demethylation of LATS1

open access: yesCell Proliferation, EarlyView.
Our study elucidates the cellular and molecular mechanisms underlying KYNA's protective effects against HIRI. It emphasises that KYNA modulates the methylation status of the Hippo signalling pathway through the activation of AHR, thereby mitigating damage by promoting LATS1 degradation and facilitating the nuclear translocation of YAP. ABSTRACT Hepatic
Wenjie Zheng   +10 more
wiley   +1 more source

Isolation and Characterisation of Serotype III in Miamiensis avidus (Ciliophora: Scuticociliatida) From Olive Flounder (Paralichthys olivaceus)

open access: yesJournal of Fish Diseases, EarlyView.
ABSTRACT Miamiensis avidus (Ciliophora: Scuticociliatida, syn. Philasterides dicentrarchi) is a significant pathogen causing scuticociliatosis in olive flounder (Paralichthys olivaceus) in Korea and Japan. In this study, the BB19 strain, isolated from olive flounder, was identified as M.
Jin‐Young Kim   +5 more
wiley   +1 more source

The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage. [PDF]

open access: yes, 2019
The type I TGFβ receptor TGFβRI (encoded by Tgfbr1) was ablated in cartilage. The resulting Tgfbr1 Col2 mice exhibited lethal chondrodysplasia. Similar defects were not seen in mice lacking the type II TGFβ receptor or SMADs 2 and 3, the intracellular ...
Baek, Jongseung   +7 more
core  

Neuroimmune pathophysiology of long COVID

open access: yesPsychiatry and Clinical Neurosciences, EarlyView.
Although COVID‐19 was originally considered a respiratory illness, it is now well established that SARS‐CoV‐2 infection can have far‐reaching impacts on the nervous system. Neurological symptoms such as chemosensory dysfunction are frequently observed during acute infection and approximately 10% of COVID‐19 cases will go on to develop new or persistent
Janna K. Moen   +2 more
wiley   +1 more source

World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis

open access: yesVeterinary Dermatology, EarlyView.
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis   +9 more
wiley   +1 more source

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