Results 181 to 190 of about 5,012,000 (246)

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

An Outbreak of Rabbit Hemorrhagic Disease in Shizuoka Prefecture

Journal of the Japan Veterinary Medical Association, 1997
ITOU, Ken-ichi, KAWASHIMA, Kazuharu, OOBA, Yoshikazu, HARITANI, Makoto, KIMURA, Takashi, ITAKURA, Chitoshi   +5 more
openaire   +2 more sources

Thermochemical Micro‐Explosion for Prompt Thrombolysis via Proximal Injection of Liquid Alkali Metal

Advanced Science, Volume 13, Issue 54, 28 September 2026.
We report a micro‐explosive thermochemical thrombolysis (METCT) therapy via injectable liquid alkali metal encapsulated in dimethyl silicone (LAM@oil). METCT enables prompt and safe vascular recanalization within 90 s. Critically, the LAM@oil system demonstrates significantly higher thrombolytic efficacy compared to clinically available thrombolytic ...
Xin Liao, Yi Hou, Jie Zhang, Bo Wang, Minghui Guo, Hua Qu, Wei Rao, Jing Liu   +7 more
wiley   +1 more source

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, Volume 13, Issue 49, 3 September 2026.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, Volume 13, Issue 50, 7 September 2026.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer's disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in the hippocampal dentate gyrus subgranular cell zone (SGZ) of 5×FAD mice was measured using ...
Weiqi Sun, Biyu Yang, Hanyuan Zheng, Qi Wang, Yajiao Shi, Gandig Wang, Wang Yin, Hui Wang, Xuetao Qi, Yun Yao, Jiaxin Wang, Shuang Cui, Kun Cui, Jian Mao, Yiyuan Xia, Jianwen Deng, Siyuan Zhao, Zhihao Wang, Fengyu Liu, Ming Yi, Jiuyang Ding, Weidong Le, Xinyan Li, Junliang Yuan, You Wan, Jie Zheng   +25 more
wiley   +1 more source

Aβ1‐40 induces venular endothelial cell ferroptosis in cerebral amyloid angiopathy via the ATF3/xCT axis: Insights from single‐cell RNA sequencing

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Amyloid‐beta (Aβ)‐induced microvascular injury is a key pathological feature of cerebral amyloid angiopathy (CAA). Recent evidence suggests that ferroptosis is implicated in Aβ pathology; however, its cell‐type specificity and regulatory mechanisms within the cerebral microvasculature in CAA remain unclear. METHODS Single‐cell RNA
Chunmei Wu, Xiaodong Ye, Hualin Chen, Yongkang Fang, Yan Lan, Jiahe Ye, Xin Liu, Ruizhi Xiao, Suiqiang Zhu, Shanshan Huang   +9 more
wiley   +1 more source

Autonomic Plexuses of the Female Sexual Organs Travel Within Pubocervical and Rectovaginal [Endopelvic] Fascia: A Rationale for ‘Nerve‐Aware’ Vaginal Prolapse Repair

Clinical Anatomy, Volume 39, Issue 6, Page 672-682, September 2026.
ABSTRACT The connective tissue support of female pelvic viscera—endopelvic fascia—has been studied in fetal and immunohistochemical models to demonstrate its relationship with the autonomic nerves of the female pelvis. Due to a paucity of literature examining the gross anatomical relationships between endopelvic fascia and autonomic nerves in adult ...
Stephen Magliocchetti, Benjamin Laxer, Leyla Spennato, Norah Alturki, Queena Chou, Tyler S. Beveridge   +5 more
wiley   +1 more source

Qianjinweijingtang Decoction and Its Granule Inhibit Respiratory Syncytial Virus Infection and the Associated Inflammatory Response

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The classical herbal formula Qianjinweijingtang in both decoction and granule forms, exhibits anti‐RSV activity. Isoliquiritigenin, quercetin, and gallic acid are identified as key active compounds. The mechanism involves interfering with viral entry and downregulating HIF‐1α and inflammatory responses, positioning the granule formulation as a ...
Chu‐Yi Liao, Mei‐Lan Yang, Ze‐Ping Chen, Bin Chen, Yu‐Jun Tang, Zhen Wang, Hui‐Nan Zhao, Su‐Hua Deng, Jin‐Hai Ye, Zhong Liu, Li‐Feng Chen, Man‐Mei Li   +11 more
wiley   +1 more source

Suprasellar Desmoplastic Infantile Ganglioglioma in a 7‐Month‐Old Infant: A Rare Diagnostic Consideration in Infant Suprasellar Masses

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Desmoplastic infantile ganglioglioma should be considered when an infant presents with a suprasellar mass, nystagmus, and developmental delay. Deep midline location limits resection, so BRAF V600E testing matters: it can open a targeted treatment option when surgery cannot control the disease.
Tawfiq Zuhair Abdullah Allaylah
wiley   +1 more source