Results 191 to 200 of about 5,012,000 (246)

Melatonin Improves Cognitive Function and Suppresses Excessive Mitophagy in Rats With Vascular Dementia

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
CCH in BCCAO‐operated rats induces excessive hippocampal mitophagy and caspase‐3 upregulation. Two‐week daily melatonin treatment promotes CBF recovery, inhibits excessive mitophagy, and reduces caspase‐3 expression levels. These mechanisms may be associated with melatonin‐mediated amelioration of cognitive dysfunction in VaD rats.
Si‐jia Hou, Xing‐yi Guo, Zhi‐gang Wang, Ting‐yan Chen, Yang Li, Sui‐yi Xu   +5 more
wiley   +1 more source

ACP5‐positive macrophages contribute to cerebral oedema and neuroinflammation after traumatic brain injury

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Integrated transcriptomic analyses identified an ACP5‐positive monocyte/macrophage population enriched in the injured brain within 1–3 days after traumatic brain injury (TBI). Pharmacological and genetic targeting of ACP5 attenuated cerebral oedema and neuroinflammation, preserved blood–brain barrier integrity, and improved long‐term cognitive outcomes.
Dang Hanhan, He Kun, Zhang Yulian, Zhang Chuanpeng, Zhang Yunsheng, Wang Zixi, Yang Xu, Chen Pengyu, Zhang Li, Yu Yanbing   +9 more
wiley   +1 more source

Advancing Type 1 Diabetes Treatment: 3 PM‐Oriented Innovations in Islet Transplantation and Biomaterial Engineering

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Type 1 Diabetes (T1D) is an autoimmune disorder marked by the immune‐mediated destruction of pancreatic β‐cells, resulting in insulin deficiency and dysregulated glucose control. Current therapies—such as insulin replacement and artificial pancreas systems—manage symptoms but fail to restore endogenous β‐cell function or halt disease ...
Fatemeh Sabet Sarvestani, Ramin Yaghobi, Mohsen Khosravi Maharlooei, Mehdi Golshan, Mohammad Hossein Karimi   +4 more
wiley   +1 more source

A decade under lens: Characterizing wildlife mortality from disease and infection in Chitwan National Park, Nepal

Ecosphere, Volume 17, Issue 9, September 2026.
Abstract Mortality and health issues are becoming an emerging issue in the conservation and management of wildlife populations. Understanding the causes of mortality is necessary for proper management of wildlife and habitats. To address this, a mixed approach was employed: we conducted a longitudinal analysis of a decade (2010–2019) of observed ...
Prabin Poudel, Thakur Silwal, Kripa Pokhrel, Beeju Poudyal, Abiral Acharya, Pushkar Pal, Sandeep Timilsina, Ganesh Prasad Tiwari   +7 more
wiley   +1 more source

Fucoxanthin Attenuates Hepatic Damage in a d‐Galactose‐Induced Accelerated Aging Mouse Model: Insight Into Underlying Mechanisms

Food Frontiers, Volume 7, Issue 5, September 2026.
Fucoxanthin alleviates d‐galactose‐induced hepatic damage by reducing oxidative stress, inflammation, and multiple programmed cell death pathways. ABSTRACT The global population is aging rapidly, and aging‐related hepatic damage poses a significant public health challenge.
Han‐Ni Wei, Cheng‐Yu Yang, Hui Li, Shi‐Xiang Wu, Qing‐Yan Zou, Yan Zheng, Kazuo Miyashita, Yu‐Hong Yang, Lei Du   +8 more
wiley   +1 more source

Investigation of the Mechanism of Total Flavonoids From Chuju in Mitigating Cerebral Ischemia–Reperfusion Injury in Rats Using Untargeted Metabolomics

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Total flavonoids of Chuju (TFCJ) protect against cerebral ischemia–reperfusion injury (CIRI) in rats by reducing infarct volume, alleviating oxidative stress, and regulating metabolic pathways including the TCA cycle, glycolysis, pentose phosphate pathway (PPP), and aspartate–glutamate metabolism.
Guanglei Zhang, Zongmeng Zhang, Cong Wang, Gaocheng Shi, Mengqi Zhao, Xianxi Wu, Xiaoyong Yuan, Hao Yu   +7 more
wiley   +1 more source

Recent advances and clinical applications of 3D printing for female reproductive organ regeneration and gynecological disease

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
This comprehensive review highlights the transformative role of 3D printing and bioprinting technologies in the regeneration of female reproductive organs and the treatment of gynecological diseases. Unlike previous overviews that focus narrowly on isolated applications, this work provides an integrative analysis of recent clinical and preclinical ...
Chan Hum Park, In‐Sun Hong
wiley   +1 more source

Current strategies to enhance the target efficiency of advanced multifunctional ultrasound contrast agents in ischemic diseases

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
The graphical abstract outlines a novel multifunctional ultrasound contrast agent for the diagnosis and treatment of ischemic diseases, along with innovative strategies to enhance its targeting efficiency. Abstract Ischemic diseases, such as myocardial infarction, stroke, and peripheral ischemia, are leading causes of death and disability worldwide ...
Yangyang Zhou, Jing Lin, Yu Chen, Jiaqi Zhao   +3 more
wiley   +1 more source

Dysregulation of the KLF9/TXNRD2 Axis Leads to Mitochondrial DNA Oxidation and NLRP3 Inflammasome Activation in Ulcerative Colitis

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
In ulcerative colitis, the transcription factor KLF9 is abnormally overexpressed and inhibits TXNRD2 transcription. As a key mitochondrial antioxidant enzyme, the loss of TXNRD2 leads to disruption of mitochondrial redox homeostasis, resulting in excessive accumulation of mtROS and mitochondrial DNA damage.
Yijia Fan, Lingling Dai, Feng Zhu, Mingfang Ping, Xiaofeng Zhu, Junguo Chen   +5 more
wiley   +1 more source

Asparagine Synthetase Deficiency: Neuropathological Evidence of Disrupted Cortical Development

JIMD Reports, Volume 67, Issue 5, September 2026.
ABSTRACT Asparagine synthetase deficiency (ASNSD) is a rare metabolic disease causing congenital microcephaly, severe developmental delay, and spastic quadriplegia. Although the central nervous system is severely affected, other organ systems appear unaffected by asparagine deficiency.
Mihaela Bobić, Goran Sedmak, Ema Bokulić, Tila Medenica, Tamara Žigman, Bernarda Medlobi Vinković, Viktorija Antolović, Nenad Kešin, Ivan Lehman, Ana Škaričić, Mirjana Novoselec, Josipa Mateševac, Monica Kirigin Kalamar, Sanda Huljev Frković, Ivo Barić, Danijela Petković Ramadža   +15 more
wiley   +1 more source