Results 41 to 50 of about 1,084,357 (231)

Detection of rabies virus nucleoprotein-RNA in several organs outside the Central Nervous System in naturally-infected vampire bats

Pesquisa Veterinária Brasileira, 2011
Rabies is a neurological disease, but the rabies virus spread to several organs outside the central nervous system (CNS). The rabies virus antigen or RNA has been identified from the salivary glands, the lungs, the kidneys, the heart and the liver.
Luiz F. P Vieira, Sílvia R.F.G Pereira, Aline C Galante, Juliana G Castilho, Rafael N Oliveira, Paulo E Brandão, Ivanete Kotait   +6 more
doaj   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

Renewed global partnerships and redesigned roadmaps for rabies prevention and control [PDF]

, 2011
Canine rabies, responsible for most human rabies deaths, is a serious global public health concern. This zoonosis is entirely preventable, but by focusing solely upon rabies prevention in humans, this "incurable wound" persists at high costs.
Wandeler, Alexander, Briggs, Deborah J., Rupprecht, Charles Edward, Hiby, E., Hervé Bourhy, Meslin ,F.-X., Thomas Müller, Louis H. Nel, Fooks, Anthony R., Lembo, T., Attlan, M., Leanes, Fernando, Tordo, Noel, Rupprecht, C.E., Nel, Louis H, Cleaveland, S., Leanes, F., Lembo, Tiziana, de Balogh, K., Dodet, B., Nel, Louis H., Tumpey, A., Dodet, Betty, Tiziana Lembo, Attlan, Michael, Bourhy, Hervé, Peter Costa, Anthony R. Fooks, Costa, P., Noël Tordo, Alexander Wandeler, Tumpey, Abbigail, Elly Hiby, Briggs, D.J., de Balogh, Katinka, Mary Elizabeth Miranda, Rupprecht, Charles E, Nel, L.H., Abbigail Tumpey, Müller, Thomas, Betty Dodet, Wandeler, A., Michaël Attlan, Katinka de Balogh, François-Xavier Meslin, Fernando Leanes, Charles E. Rupprecht, Miranda, M.E., Costa, Peter, Miranda, Mary Elizabeth, Meslin, François-Xavier, Tordo, N., Briggs, Deborah J, Wandeler, A.I. (Alexander I.), Fooks, A.R., Nel, Louis Hendrik, Hiby, Elly F., Deborah J. Briggs, Rupprecht, Charles E., Fooks, Anthony R, Cleaveland, Sarah, Sarah Cleaveland, Bourhy, H., Hiby, Elly   +63 more
core   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Spatio-temporal Use of Oral Rabies Vaccines in Fox Rabies Elimination Programmes in Europe. [PDF]

PLoS Neglected Tropical Diseases, 2015
In Europe, the elimination of wildlife rabies using oral rabies vaccination [ORV] of foxes for more than 30 years has been a success story. Since a comprehensive review on the scope of the different oral rabies vaccine baits distributed across Europe has
Thomas F Müller, Ronald Schröder, Patrick Wysocki, Thomas C Mettenleiter, Conrad M Freuling   +4 more
doaj   +1 more source

Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response

Advanced Science, EarlyView.
This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du, Liping Wang, Sujing Diao, Juan Li, Lei Zhao, Yan Yan, Haimin Li, Weiren Dong, Wei Wu, Jinyan Gu, Jiyong Zhou   +10 more
wiley   +1 more source

Antiviral Ranpirnase TMR-001 Inhibits Rabies Virus Release and Cell-to-Cell Infection In Vitro

Viruses, 2020
Currently, no rabies virus-specific antiviral drugs are available. Ranpirnase has strong antitumor and antiviral properties associated with its ribonuclease activity.
Todd G. Smith, Felix R. Jackson, Clint N. Morgan, William C. Carson, Brock E. Martin, Nadia Gallardo-Romero, James A. Ellison, Lauren Greenberg, Thomas Hodge, Luis Squiquera, Jamie Sulley, Victoria A. Olson, Christina L. Hutson   +12 more
doaj   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Estimating the public health impact of rabies. [PDF]

, 2004
Rabies is a fatal, preventable zoonosis, but it is not effectively controlled throughout much of the developing world. The impetus for control is hampered by a lack of awareness of its true impact. We estimate a disability-adjusted life year (DALY) score
Coleman, Paul G, Cleaveland, Sarah, Fèvre, Eric M., Paul G. Coleman, Sarah Cleaveland, Coleman, P.G., Eric M. Fèvre, Fèvre, Eric M, Cleaveland, S.   +8 more
core   +1 more source