Results 61 to 70 of about 1,739,706 (302)

Rabies elimination research: juxtaposing optimism, pragmatism and realism [PDF]

, 2017
More than 100 years of research has now been conducted into the prevention, control and elimination of rabies with safe and highly efficacious vaccines developed for use in human and animal populations. Domestic dogs are a major reservoir for rabies, and
Bögel K, Cleaveland S, Debre P, Ferguson EA, Garside D, GBD, Hampson K, Harischandra LPA, King AA, Knobel D, Knobel DL, Pemberton N, Wandeler AI, Woodroffe R   +13 more
core   +1 more source

Detection of rabies virus nucleoprotein-RNA in several organs outside the Central Nervous System in naturally-infected vampire bats

Pesquisa Veterinária Brasileira, 2011
Rabies is a neurological disease, but the rabies virus spread to several organs outside the central nervous system (CNS). The rabies virus antigen or RNA has been identified from the salivary glands, the lungs, the kidneys, the heart and the liver.
Luiz F. P Vieira, Sílvia R.F.G Pereira, Aline C Galante, Juliana G Castilho, Rafael N Oliveira, Paulo E Brandão, Ivanete Kotait   +6 more
doaj   +1 more source

Rabies virus modifies host behaviour through a snake-toxin like region of its glycoprotein that inhibits neurotransmitter receptors in the CNS

Scientific Reports, 2017
Rabies virus induces drastic behaviour modifications in infected hosts. The mechanisms used to achieve these changes in the host are not known. The main finding of this study is that a region in the rabies virus glycoprotein, with homologies to snake ...
K. Hueffer, Shailesh N. Khatri, S. Rideout, M. Harris, R. Papke, C. Stokes, M. Schulte   +6 more
semanticscholar   +1 more source

Spatio-temporal Use of Oral Rabies Vaccines in Fox Rabies Elimination Programmes in Europe. [PDF]

PLoS Neglected Tropical Diseases, 2015
In Europe, the elimination of wildlife rabies using oral rabies vaccination [ORV] of foxes for more than 30 years has been a success story. Since a comprehensive review on the scope of the different oral rabies vaccine baits distributed across Europe has
Thomas F Müller, Ronald Schröder, Patrick Wysocki, Thomas C Mettenleiter, Conrad M Freuling   +4 more
doaj   +1 more source

Antigenicity of rabies virus glycoprotein [PDF]

Journal of Virology, 1991
Although the number of antigenic sites on the rabies virus glycoprotein that have been described regularly increases with time, no attempt has been made to carefully evaluate the relative importance of each of these sites. Here we provide a more precise description of the antigenicity of the protein in mice of the H-2d haplotype; we developed this ...
Christine Tuffereau, H. Leblois, Florence Lafay, Abdenour Benmansour, Yves Gaudin, Anne Flamand, Patrice Coulon   +6 more
openaire   +3 more sources

Identification of Two Classes of Somatosensory Neurons That Display Resistance to Retrograde Infection by Rabies Virus

Journal of Neuroscience, 2017
Glycoprotein-deleted rabies virus-mediated monosynaptic tracing has become a standard method for neuronal circuit mapping, and is applied to virtually all parts of the rodent nervous system, including the spinal cord and primary sensory neurons.
Gioele W. Albisetti, Alexander Ghanem, E. Foster, K. Conzelmann, H. Zeilhofer, H. Wildner   +5 more
semanticscholar   +1 more source

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

Advanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin, Lianhua Yin, Weilin Liu, Rui Li, Tao Jiang, Minguang Yang, Yajun Cao, Sinuo Wang, Yan Yu, Cong Chen, Xiaoqin Guo, Wenju Wang, Huanhuan Liu, Yaling Dai, Jiamin Yan, Yanting Lin, Yanyi Ding, Chendong Ruan, Lei Yang, Tiecheng Wu, Jing Tao, Lidian Chen   +21 more
wiley   +1 more source

Rabies on the Last Frontier: A Phylogeographical Look at Red (Vulpus vulpus) and Arctic (Vulpus lagopus) Fox with Respect to Mitochondrial DNA and the Spatial Diffusion of Rabies [PDF]

, 2012
Vulpus vulpus and Vulpus lagopus are terrestrial animals that live in Alaska. They are also common carriers of the rabies virus. It has been determined that there are three different clades of rabies in Alaska being vectored by these two species of fox,
Clement, Christopher J.
core  

Landscape attributes governing local transmission of an endemic zoonosis: rabies virus in domestic dogs [PDF]

, 2018
Landscape heterogeneity plays an important role in disease spread and persistence, but quantifying landscape influences and their scale dependence is challenging.
Biek, Roman, Brunker, Kirstyn, Fooks, Anthony R., Hampson, Katie, Lemey, Philippe, Lugelo, Ahmed, Marston, Denise A., Ngeleja, Chanasa   +7 more
core   +1 more source

Recent Advances in mRNA Delivery Systems for Cancer Therapy

Advanced Science, EarlyView.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang, Ya‐Nan Fan, Si‐Qi Jiang, Ya‐Jing Ma, Yao‐Ru Yu, Yu‐Xin Qing, Qian‐Ru Li, Yi‐Lin Liu, Song Shen, Jun Wang   +9 more
wiley   +1 more source