Results 301 to 310 of about 131,005 (322)

Orchestrating movement: the role of Caveolin-1 in migration and metastasis. [PDF]

Mol Cancer
Navratil J, Raudenska M, Kratochvilova M, Balvan J, Shaul YD, Masarik M.   +5 more
europepmc   +1 more source

Rnd3 regulates cell morphodynamics by spatial restriction of cell contraction signaling

Sachan A, Gierse C, Nanda S, Xin X, Wu Y, Dehmelt L.   +5 more
europepmc   +1 more source

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Characterisation and outcome of RAC1 mutated melanoma

European Journal of Cancer, 2022
Activating hot spot R29S mutations in RAC1, a small GTPase influencing several cellular processes including cell proliferation and cytoskeleton rearrangement, have been reported in up to 9% of sun-exposed melanomas. Clinical characteristics and treatment implications of RAC1 mutations in melanoma remain unclear.We investigated the largest set (n = 64 ...
Georg C. Lodde, Philipp Jansen, Rudolf Herbst, Patrick Terheyden, Jochen Utikal, Claudia Pföhler, Jens Ulrich, Alexander Kreuter, Peter Mohr, Ralf Gutzmer, Friedegund Meier, Edgar Dippel, Michael Weichenthal, Antje Sucker, Jan-Malte Placke, Anne Zaremba, Lea Jessica Albrecht, Bernd Kowall, Wolfgang Galetzka, Jürgen C. Becker, Alpaslan Tasdogan, Lisa Zimmer, Elisabeth Livingstone, Eva Hadaschik, Dirk Schadendorf, Selma Ugurel, Klaus Griewank   +26 more
openaire   +2 more sources

Phosphatidylserine Recruits Rac1

Science's STKE, 2006
Rac1 is a member of the Rho family of guanosine triphosphatases (GTPases) and is involved in stimulating membrane ruffling and cell migration. Finkielstein et al . show, using liposome-binding assays, nuclear magnetic resonance assays, and lipid overlay assays, that purified Rac1, either prenylated or nonprenylated,
openaire   +1 more source

Depressed Without Rac1

Science Signaling, 2013
Treatments that target the GTPase RAC1 signaling could be developed as antidepressants.
openaire   +1 more source

Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer

Nature Metabolism, 2022
Juan Liu, Cen Zhang, Tianliang Zhang, Chun-Yuan Chang, Jianming Wang, Ludvinna Bazile, Lanjing Zhang, B. Haffty, Wenwei Hu, Zhaohui Feng   +9 more
semanticscholar   +1 more source

Rac1 and Cholesterol Metabolism in Macrophage

Journal of Cardiovascular Pharmacology, 2013
In the early stages of atherosclerotic lesion development, cholesterol is mostly present as esterified cholesterol stored in macrophage cytoplasmic lipid droplets. However, when the lesion evolves, free cholesterol accumulates in other compartments, such as lysosomes and plasma membrane.
ADORNI, Maria Pia, RONDA, Nicoletta, BERNINI, Franco, FAVARI, Elda   +3 more
openaire   +3 more sources

Drosophila Rac1 controls motor axon guidance

Development, 1998
ABSTRACT Previous genetic studies of intersegmental nerve b development have identified several cell-surface proteins required for correct axon guidance to appropriate target muscles. Here we provide evidence that the small GTPase Drac1 also plays a key role in this guidance process.
N, Kaufmann, Z P, Wills, D, Van Vactor
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Rac1 and Rac2 GTPases in haematopoiesis

BioEssays, 2004
AbstractThe highly homologous Rac1 and Rac2 GTPases are co‐expressed in cells of haematopoietic origin and are likely to show some functional redundancy. While disruption of the Rac2 gene in mice has provided insight into some of its functions, Rac1 null mice are embryonic lethal and only recently has conditional gene disruption been possible ...
Victoria J, Weston, Tatjana, Stankovic
openaire   +2 more sources