Results 71 to 80 of about 701 (178)
Our study shows that a second reading at D4 (24.9%) enchances the sensitivity of a first reading at D3 (13.7%) for the patients' positivity of PTs with suspect drugs in the exploration of NICADR (p < 0.0001). Late readings should not be carried out on D3 because of an important loss of sensibility compared to D4.
Ilaria Matei +9 more
wiley +1 more source
Acute watery diarrhea (AWD) is a significant contributor to morbidity as well as mortality among underfive children, predominantly in resource-limited settings.
Hassan Jamil +4 more
doaj +1 more source
Opioid Facilitation of β-Adrenergic Blockade: A New Pharmacological Condition?
Recently, propranolol was suggested to prevent hyperlactatemia in a child with hypovolemic shock through β-adrenergic blockade. Though it is a known inhibitor of glycolysis, propranolol, outside this observation, has never been reported to fully protect ...
Joseph Vamecq +3 more
doaj +1 more source
Many drugs have been shown to be metabolized by the human gut microbiome, but probiotic-driven drug-metabolizing capacity is rarely explored. Here, we developed an integrated metabolomics, culturomics, and bionics framework for systematically studying ...
Dandan Wang (286632) +5 more
core +1 more source
Long term outcomes in children with trichohepatoenteric syndrome
Abstract Trichohepatoenteric syndrome (THES) is a rare autosomal recessive disorder caused by mutations in either TTC37 or SKIV2L, usually leading to congenital diarrhea as part of a multisystem disease. Here, we report on the natural history of the disease for the largest UK cohort of patients with THES from 1996 to 2020.
Kwang Yang Lee +6 more
wiley +1 more source
Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled, proof-of-concept trial. [PDF]
BACKGROUND AND PURPOSE: Pulmonary arterial hypertension (PAH) is an incurable, incapacitating disorder resulting from increased pulmonary vascular resistance, pulmonary arterial remodeling and right ventricular failure.
Hobbs AJ +14 more
europepmc +3 more sources
Role of Antidiarrhoeal Drugs as Adjunctive Therapies for Acute Diarrhoea in Children
Acute diarrhoea is a leading cause of child mortality in developing countries. Principal pathogens include Escherichia coli, rotaviruses, and noroviruses. 90% of diarrhoeal deaths are attributable to inadequate sanitation.
Christophe Faure
doaj +1 more source
WhatIs Known and Objective. Anti‐EGFR (epidermal growth factor receptor) drugs are indicated for non‐small‐cell lung cancer (NSCLC). This review summarises the information available to date on the first anti‐EGFRs granted market authorisation: erlotinib TARCEVA®, gefitinib IRESSA®, afatinib GIOTRIF®, dacomitinib VIZIMPRO®, and osimertinib TAGRISSO ...
Constance Bordet +5 more
wiley +1 more source
Validated RP-HPLC Method For Simultaneous Estimation of Ofloxacin and Racecadotril in Bulk and Combined Pharmaceutical Formulations [PDF]
Combined drug dosage forms are highly used since they can target more than one disease. For Ofloxacin and Racecadotril in bulk and combined dosage form a simple ,accurate and precise stability indicating simultaneous method was developed and validated by
Das, Debashree Debasish, Chawla, Pooja
core
Many drugs have been shown to be metabolized by the human gut microbiome, but probiotic-driven drug-metabolizing capacity is rarely explored. Here, we developed an integrated metabolomics, culturomics, and bionics framework for systematically studying ...
Dandan Wang (286632) +5 more
core +1 more source

