Results 51 to 60 of about 661 (153)

Prediction and identification of synergistic compound combinations against pancreatic cancer cells. [PDF]

, 2021
Resistance to current therapies is common for pancreatic cancer and hence novel treatment options are urgently needed. In this work, we developed and validated a computational method to select synergistic compound combinations based on transcriptomic ...
Bender, Andreas, Bramhall, Jo L, Choi, Ran Joo, Fan, Tai-Ping, KalantarMotamedi, Yasaman, Koh, Siang-Boon   +5 more
core   +4 more sources

Future Prospects of Imatinib in Advanced Pulmonary Hypertension Management

IUBMB Life, Volume 78, Issue 3, March 2026.
ABSTRACT Pulmonary arterial hypertension (PAH) is a severe, progressive disease characterized by elevated pulmonary arterial pressure and increased vascular resistance. This hemodynamic strain forces the right ventricle to pump against a high‐pressure system, ultimately leading to right‐sided heart failure and death.
Federica Davì, Stella Mangione, Antonella Iaconis, Tiziana Genovese, Nicla Tranchida, Salvatore Cuzzocrea   +5 more
wiley   +1 more source

Rethinking the AI Paradigm for Solubility Prediction of Drug‑Like Compounds with Dual‐Perspective Modeling and Experimental Validation

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Aqueous solubility governs drug delivery and bioavailability, yet its prediction remains challenging. Utilizing the largest curated dataset of drug‐like molecules, prediction models are constructed through dual‐perspective benchmarking. Stacking methods outperform advanced deep learning due to data constraints. These validated models enabled systematic
Qilin Zhu, Yuxin Qiu, Guzhong Chen, Wenyao Chen, Xiang Zhang, Zhiwen Qi, Xuezhi Duan, De Chen, Zhen Song   +8 more
wiley   +1 more source

Role of Racecadotril in Children with Acute Diarrhea

Dhaka Shishu (Children) Hospital Journal, 2021
Background: Diarrhea is a leading cause of illness and death among children in developing countries. Racecadotril (acetorphan), an enkephalinase inhibitor with antisecretory and anti-diarrheal actions, is an effective and safe treatment for acute diarrhea in adults and children. Objectives: The objective of this study is to evaluate the efficacy ...
Sheikh Farjana Sonia, Sharmin Afroze, Kazi Iman, Uzzal Kumar Ghosh, Shahidul Islam, Parijat Bishwas, Azmeri Sultana   +6 more
openaire   +1 more source

Amyloidosis for the Gastroenterologist: A Comprehensive Systematic Review of Diagnosis and Management of Gastrointestinal Manifestations

Journal of Gastroenterology and Hepatology, Volume 40, Issue 12, Page 2842-2856, December 2025.
ABSTRACT Background Amyloidosis is a rare, multisystem disorder characterized by extracellular deposition of misfolded protein fibrils. Gastrointestinal (GI) amyloidosis is uncommon but under‐recognized due to nonspecific symptoms, but early diagnosis is critical to improve quality of life and prognosis.
Myo Jin Tang, Theng Yi Tay, Simon Gibbs, Ola Niewiadomski   +3 more
wiley   +1 more source

Development and Validation of a High Performance Liquid Chromatography Method for the Determination of Bromopride in the Presence of Methylparaben and Propylparaben in Pharmaceutical Formulations

SEPARATION SCIENCE PLUS, Volume 8, Issue 11, November 2025.
ABSTRACT A reversed‐phase high‐performance liquid chromatography method was developed and validated for the determination of bromopride (BROP) in the presence of methylparaben and propylparaben, using isocratic mode, C18 chromatographic column, mobile phase composed of acetonitrile and aqueous phase previously acidified with phosphoric acid to pH 3.5 ...
Francielli Gelatti Bortoly Carvalho, Patrícia Espinosa dos Santos, Elaine de Oliveira Araújo, Marcos Serrou do Amaral, Teófilo Fernando Mazon Cardoso, Nájla Mohamad Kassab   +5 more
wiley   +1 more source

Clinical Characteristics and Safety Profiles of Japanese Psoriasis Patients Who Continued Apremilast Treatment for 6 and 12 Months: A Post Hoc Analysis of an Apremilast Postmarketing Surveillance Study

The Journal of Dermatology, Volume 52, Issue 6, Page 1059-1065, June 2025.
ABSTRACT Apremilast is a phosphodiesterase 4 inhibitor approved for moderate to severe psoriasis in Japan. Apremilast significantly improved Physician's Global Assessment (PGA) and Dermatology Life Quality Index (DLQI) both at 6 and 12 months in a previously published primary post‐surveillance study.
Mamitaro Ohtsuki, Yukari Okubo, Hidehisa Saeki, Atsuyuki Igarashi, Shinichi Imafuku, Masatoshi Abe, Katsuya Saito, Ryuichi Ogawa, Akimichi Morita   +8 more
wiley   +1 more source

Evaluating the cost utility of racecadotril for the treatment of acute watery diarrhea in children: the RAWD model

ClinicoEconomics and Outcomes Research, 2012
Tamlyn Anne Rautenberg1,2, Ute Zerwes1, Douglas Foerster3,4, Rick Aultman51Assessment in Medicine GmbH, Lörrach, Germany; 2Leeds Institute of Health Sciences, University of Leeds, Leeds, United Kingdom; 3Abbott Products Operations AG, Allschwil,
Rautenberg TA, Zerwes U, Foerster D, Aultman R   +3 more
doaj  

Opioid Facilitation of β-Adrenergic Blockade: A New Pharmacological Condition?

Pharmaceuticals, 2015
Recently, propranolol was suggested to prevent hyperlactatemia in a child with hypovolemic shock through β-adrenergic blockade. Though it is a known inhibitor of glycolysis, propranolol, outside this observation, has never been reported to fully protect ...
Joseph Vamecq, Karine Mention-Mulliez, Francis Leclerc, Dries Dobbelaere   +3 more
doaj   +1 more source

FORMULATION AND EVALUATION OF RACECADOTRIL MUCOADHESIVE MICROSPHERES

International Journal of Pharmacy and Pharmaceutical Sciences, 2019
Objective: To develop and evaluate the mucoadhesive microsphere using combinations of natural polymers chitosan and xanthan gum for sustained release. Methods: In the present work mucoadhesive microspheres were prepared by using natural polymers like chitosan and xanthan gum by using the emulsion chemical cross-linking method.
KANCHAN JAMKAR, SWATI MUTHA, SHARWAREE HARDIKAR, NIKHIL KUMBHAR   +3 more
openaire   +2 more sources