Results 31 to 40 of about 131 (115)
British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2162-2170, July 2026.Aims Ocrelizumab is a humanized anti‐CD20 monoclonal antibody used in multiple sclerosis. Since its commercialization, several cases of ocrelizumab‐induced colitis have been reported in the scientific literature. Methods To explore the potential association of ocrelizumab with colitis as an adverse drug reaction (ADR), we conducted a descriptive and ...
Audrey Fresse +3 more
wiley +1 more source
Comparison of racecadotril and loperamide in children with acute diarrhoea [PDF]
Alimentary Pharmacology & Therapeutics, 1999 MethodsA multicentre, parallel‐group, double‐blind, double‐placebo study was carried out to compare the efficacy, tolerability, and safety of racecadotril and loperamide in children aged 2 to 10 years who were suffering from acute diarrhoea. Patients received racecadotril (1.5 mg/kg) or loperamide (0.03 mg/kg) three times daily plus matching placebo ...
D, Turck +3 more
openaire +2 more sources
Clinical and Translational Science, Volume 19, Issue 5, May 2026.ABSTRACT In the wake of the ongoing opioid epidemic, the incidence of neonatal opioid withdrawal syndrome (NOWS) has surged. While the short‐term effects of NOWS are well‐characterized, long‐term physiological and molecular consequences remain unclear.
Sara L. Mills‐Huffnagle +4 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 4, April 2026.The methanolic extract of Syngonium podophyllum flower demonstrated significant anthelmintic, antidiabetic, antidiarrheal, and antipyretic effects across all in vitro and in vivo experimental models. Furthermore, in silico studies revealed that these phytoconstituents exhibit favorable pharmacokinetic properties, interact with key therapeutic target ...
Mahathir Mohammad +9 more
wiley +1 more source
ChemSusChem, Volume 19, Issue 6, 27 March 2026.Amide bond formation is central to active pharmaceutical ingredient (API) synthesis. A bio‐organocatalytic cascade is reported, merging stereoselective ω‐transaminase (ω‐TA) transamination in neat organic solvent with choline chloride‐mediated amidation under solvent‐free microwave conditions.
Salvatore Romano +7 more
wiley +1 more source
Future Prospects of Imatinib in Advanced Pulmonary Hypertension Management
IUBMB Life, Volume 78, Issue 3, March 2026.ABSTRACT Pulmonary arterial hypertension (PAH) is a severe, progressive disease characterized by elevated pulmonary arterial pressure and increased vascular resistance. This hemodynamic strain forces the right ventricle to pump against a high‐pressure system, ultimately leading to right‐sided heart failure and death.
Federica Davì +5 more
wiley +1 more source
Advanced Science, Volume 12, Issue 46, December 11, 2025.Aqueous solubility governs drug delivery and bioavailability, yet its prediction remains challenging. Utilizing the largest curated dataset of drug‐like molecules, prediction models are constructed through dual‐perspective benchmarking. Stacking methods outperform advanced deep learning due to data constraints. These validated models enabled systematic
Qilin Zhu +8 more
wiley +1 more source
Pathogenetic Mechanisms of Diarrhea in Children and Methods for Its Treatment
Zdorovʹe Rebenka, 2014 The paper presents the current views on the pathogenesis of acute intestinal infections in children and principles of therapy of diarrhea syndrome. Particular attention is paid to antisecretory therapy and the role of racecadotril in relieving diarrhea.
B.I. Krivuschev
doaj +1 more source
Racecadotril versus placebo in the treatment of acute diarrhoea in adults [PDF]
Alimentary Pharmacology & Therapeutics, 1999 MethodsA two‐centre, double‐blind, parallel‐group, randomized study was carried out to compare the efficacy and tolerability of racecadotril (100 mg three times daily) and placebo in 70 adult patients with acute diarrhoea. An objective criterion of antisecretory activity, stool weight, was used.ResultsRacecadotril produced a significant (P = 0.025 ...
H, Hamza +4 more
openaire +2 more sources
Journal of Gastroenterology and Hepatology, Volume 40, Issue 12, Page 2842-2856, December 2025.ABSTRACT Background Amyloidosis is a rare, multisystem disorder characterized by extracellular deposition of misfolded protein fibrils. Gastrointestinal (GI) amyloidosis is uncommon but under‐recognized due to nonspecific symptoms, but early diagnosis is critical to improve quality of life and prognosis.
Myo Jin Tang +3 more
wiley +1 more source