Experimental design beats the conventional one variable at a time (OVAT) to improve the chromatographic separations with lowest consumption of resources and maximum acceptable results for the separated peaks.
Nada Nabil +3 more
doaj +2 more sources
Application of High-Performance Thin-layer Chromatographic Method for Simultaneous Determination of Co-formulated Ofloxacin and Racecadotril in their Oral Dosage Form [PDF]
Objectives: This study aimed to develop and validate a simple, rapid, economical, precise and accurate HPTLC method for simultaneous determination of ofloxacin and racecadotril has been developed.
Nasr El-Abasawi +4 more
doaj +1 more source
Background and aim Previous studies have shown that Racecadotril is safer and more effective in treating children with acute diarrhea. This study aimed to evaluate the effect of Racecadotril as a booster to oral rehydration solution in the management of ...
Reham M Sayed +2 more
doaj +1 more source
A Scoping Review of Non-Opioid Therapeutics for Opioid Withdrawal: Translational Relevance to Neonatal Opioid Withdrawal Syndrome (NOWS) Research. [PDF]
ABSTRACT In the wake of the ongoing opioid epidemic, the incidence of neonatal opioid withdrawal syndrome (NOWS) has surged. While the short‐term effects of NOWS are well‐characterized, long‐term physiological and molecular consequences remain unclear.
Mills-Huffnagle SL +4 more
europepmc +2 more sources
APPLICATION OF HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS DETERMINATION OF RACECADOTRIL AND OFLOXACIN IN THEIR PHARMACEUTICAL DOSAGE FORM [PDF]
Racecadotril and ofloxacin are co-formulated for treatment of acute symptomatic diarrhea. In the present work RP-HPLC method was developed for simultaneous determination of racecadotril and ofloxacin in the combined dosage form.
Mohamed Kamel
doaj +1 more source
Drugs in Focus: The Use of Racecadotril in Paediatric Gastrointestinal Disease [PDF]
Acute diarrhoea is a leading cause of morbidity and mortality in the paediatric population. Racecadotril is an antisecretory drug recommended as an adjuvant anti-diarrhoeal treatment. In the small bowel, the enzyme neutral endopeptidase (NEP) inhibits
Orel, R +11 more
core +2 more sources
Future Prospects of Imatinib in Advanced Pulmonary Hypertension Management. [PDF]
ABSTRACT Pulmonary arterial hypertension (PAH) is a severe, progressive disease characterized by elevated pulmonary arterial pressure and increased vascular resistance. This hemodynamic strain forces the right ventricle to pump against a high‐pressure system, ultimately leading to right‐sided heart failure and death.
Davì F +5 more
europepmc +2 more sources
Ocrelizumab-induced colitis: VigiBase disproportionality analysis, case reports and literature review. [PDF]
Aims Ocrelizumab is a humanized anti‐CD20 monoclonal antibody used in multiple sclerosis. Since its commercialization, several cases of ocrelizumab‐induced colitis have been reported in the scientific literature. Methods To explore the potential association of ocrelizumab with colitis as an adverse drug reaction (ADR), we conducted a descriptive and ...
Fresse A +3 more
europepmc +2 more sources
Summary Bradykinin‐mediated angioedema is a rare, non‐allergic, potentially life‐threatening disease. ACE inhibitor‐induced angioedema and hereditary angioedema (HAE) are the two most common presentations. Therapeutic options, pathophysiology and diagnosis continue to be investigated, with considerable progress in HAE over the last few decades. For all
Robin Lochbaum +3 more
wiley +1 more source

