CRISPR/Cas9-engineering of Kell null erythrocytes to unveil host targeted irresistible antimalarial [PDF]
Communications BiologyMalaria elimination faces challenges from drug resistance, stemming from mutations within the parasite’s genetic makeup. Genetic adaptations in key erythrocyte proteins offer malaria protection in endemic regions.
Geeta Kumari +15 more
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Cost utility, budget impact, and scenario analysis of racecadotril in addition to oral rehydration for acute diarrhea in children in Malaysia [PDF]
ClinicoEconomics and Outcomes Research, 2018 Tamlyn Anne Rautenberg,1,2 Ute Zerwes,3 Way Seah Lee4 1IGES Institut GmbH, Berlin, Germany; 2Health Economics and HIV/AIDS Research Division (HEARD), University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa; 3Assessment in Medicine GmbH, Lö ...
Rautenberg TA, Zerwes U, Lee WS
doaj +2 more sources
Stereoselective Bio-Organocatalytic Cascade to Chiral Amides as Active Pharmaceutical Ingredient Intermediates Using ω-Transaminase and Choline Chloride Under Microwave Irradiation. [PDF]
ChemSusChemAmide bond formation is central to active pharmaceutical ingredient (API) synthesis. A bio‐organocatalytic cascade is reported, merging stereoselective ω‐transaminase (ω‐TA) transamination in neat organic solvent with choline chloride‐mediated amidation under solvent‐free microwave conditions.
Romano S +7 more
europepmc +2 more sources
Randomized trial to assess the efficacy and safety of xyloglucan for the treatment of acute gastroenteritis in children. [PDF]
Food Sci Nutr, 2023 Xyloglucan is effective and safe in moderate‐to‐severe diarrhea in children 3 months to 5 years. Abstract Acute gastroenteritis is one of the most common diseases in children and an important cause of morbidity and mortality worldwide. No specific treatment is available; therefore, management is exclusively symptomatic.
Perez-Garcia MJ +17 more
europepmc +2 more sources
Talanta OpenExperimental design beats the conventional one variable at a time (OVAT) to improve the chromatographic separations with lowest consumption of resources and maximum acceptable results for the separated peaks.
Nada Nabil +3 more
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A Scoping Review of Non-Opioid Therapeutics for Opioid Withdrawal: Translational Relevance to Neonatal Opioid Withdrawal Syndrome (NOWS) Research. [PDF]
Clin Transl SciABSTRACT In the wake of the ongoing opioid epidemic, the incidence of neonatal opioid withdrawal syndrome (NOWS) has surged. While the short‐term effects of NOWS are well‐characterized, long‐term physiological and molecular consequences remain unclear.
Mills-Huffnagle SL +4 more
europepmc +2 more sources
Application of High-Performance Thin-layer Chromatographic Method for Simultaneous Determination of Co-formulated Ofloxacin and Racecadotril in their Oral Dosage Form [PDF]
Journal of Advanced Pharmacy Research, 2020 Objectives: This study aimed to develop and validate a simple, rapid, economical, precise and accurate HPTLC method for simultaneous determination of ofloxacin and racecadotril has been developed.
Nasr El-Abasawi +4 more
doaj +1 more source
Racecadotril for acute diarrhoea in children. [PDF]
Cochrane Database Syst Rev, 2019 Acute diarrhoea is a leading cause of death for children under five years of age. Most deaths are caused by excessive fluid and electrolyte losses. Racecadotril is an anti-secretory drug that has been used for acute diarrhoea in children as an adjunct to oral rehydration therapy.To assess the efficacy and safety of racecadotril for treating acute ...
Liang Y +4 more
europepmc +4 more sources
Bezmiâlem Science, 2023 Objective:In this study, a simple and selective ultra-performance liquid chromatography method for the determination of racecadotril in pharmaceutical dosage forms has been developed.Methods:The method is in reverse phase C18 column; based on the ...
Armağan ÖNAL, Emrullah BİNAY
doaj +1 more source
Al-Azhar Assiut Medical Journal, 2022 Background and aim Previous studies have shown that Racecadotril is safer and more effective in treating children with acute diarrhea. This study aimed to evaluate the effect of Racecadotril as a booster to oral rehydration solution in the management of ...
Reham M Sayed +2 more
doaj +1 more source