Racecadotril Versus Loperamide for Acute Diarrhea of Infectious Origin in Adults: A Systematic Review and Meta‐Analysis [PDF]
Health Science ReportsBackground and Aims Loperamide and racecadotril are two antidiarrheal medications with different mechanisms of action that are highly important for the treatment of diarrhea as a result of infectious pathology.
Ömer Farooq, Inibehe Ime Okon
exaly +4 more sources
Racecadotril induced bilateral uveal effusion: a case report [PDF]
BMC OphthalmologyBackground Uveal effusion is a sight threatening condition, due to possible acute angle-closure glaucoma and maculopathy. We present a case of bilateral uveal effusion after taking racecadotril, an enkephalinase inhibitor used as a medical treatment for ...
Pieter-Paul Schauwvlieghe
exaly +6 more sources
Racecadotril in the management of diarrhea: an underestimated therapeutic option? [PDF]
Therapeutic Advances in GastroenterologyAcute infectious diarrhea (AID) represents an important clinical entity both regarding morbidity and mortality rates, even in industrialized countries, and it leads to one of the major public health burdens, among gastroenterological diseases, with ...
Marco Manfredi +2 more
exaly +3 more sources
Integrating metabolomics, bionics, and culturomics to study probiotics-driven drug metabolism [PDF]
Frontiers in Pharmacology, 2023 Many drugs have been shown to be metabolized by the human gut microbiome, but probiotic-driven drug-metabolizing capacity is rarely explored. Here, we developed an integrated metabolomics, culturomics, and bionics framework for systematically studying ...
Bohai Li +17 more
doaj +2 more sources
Understanding the Anti-Diarrhoeal Properties of Incomptines A and B: Antibacterial Activity against Vibrio cholerae and Its Enterotoxin Inhibition [PDF]
Pharmaceuticals, 2022 Incomptines A (IA) and B (IB) are two sesquiterpene lactones with antiprotozoal, antibacterial, cytotoxic, antitumor, spermicidal, and phytotoxic properties.
Fernando Calzada +7 more
doaj +2 more sources
Research in Pharmaceutical Sciences, 2021 Background and purpose: Although pain is one of the most common symptoms of diseases, it is often mismanaged due to limited access to painkillers and ineffectiveness, unacceptable side effects, or the possibility of abuse.
Mehdi Asadi +5 more
doaj +2 more sources
Frontiers in Medicine, 2016 Racecadotril is a guideline-recommended treatment to alleviate symptoms of acute diarrhea. A systematic review of randomized studies was performed comparing efficacy and safety of treatment with racecadotril to that with placebo or active treatments in ...
W Fischbach +2 more
exaly +3 more sources
Frontiers in Pharmacology, 2012 Racecadotril, via its active metabolite thiorphan, is an inhibitor of the enzyme neutral endopeptidase (NEP, EC 3.4.24.11), thereby increasing exposure to NEP including enkephalins and atrial natriuretic peptide.
Martin C Michel, Michel Martin C
exaly +3 more sources
National Consensus for the Management of Acute Gastroenteritis in Jordanian Children: Consensus Recommendations Endorsed by the Jordanian Paediatric Society [PDF]
International Journal of Pediatrics, 2022 Diarrhoeal diseases are one of the leading worldwide preventable causes of death among children under 5 years of age. Almost half of children do not receive optimal acute gastroenteritis (AGE) treatment in Jordan.
Mohammed Rawashdeh +6 more
doaj +2 more sources
Racecadotril in the treatment of acute diarrhea in children: a systematic, comprehensive review and meta-analysis of randomized controlled trials [PDF]
BMC Pediatrics, 2018 Background Racecadotril is a guideline-recommended option for the treatment of acute diarrhea in children but existing guidelines and previous reviews of the field are based on a small fraction of published evidence.
Marion Eberlin +3 more
doaj +2 more sources