Results 41 to 50 of about 511 (145)

Role of Racecadotril in Children with Acute Diarrhea

Dhaka Shishu (Children) Hospital Journal, 2021
Background: Diarrhea is a leading cause of illness and death among children in developing countries. Racecadotril (acetorphan), an enkephalinase inhibitor with antisecretory and anti-diarrheal actions, is an effective and safe treatment for acute diarrhea in adults and children. Objectives: The objective of this study is to evaluate the efficacy ...
Sheikh Farjana Sonia, Sharmin Afroze, Kazi Iman, Uzzal Kumar Ghosh, Shahidul Islam, Parijat Bishwas, Azmeri Sultana   +6 more
openaire   +1 more source

Determination of racecadotril by HPLC in capsules

Indian Journal of Pharmaceutical Sciences, 2007
A simple, precise and rapid RP-HPLC method was developed for the determination of racecadotril in a pharmaceutical formulation using gemfibrozil as internal standard. Ratio of the peak area of analyte to internal standard was used for quantification. The chromatographic separation was carried out by using a Reverse Phase C18 column (BDS-Hypersil).
A Shirwaikar, SL Prabu, T Singh, A Joseph, CDinesh Kumar   +4 more
openaire   +1 more source

Multifaceted Evaluation of Syngonium podophyllum Flower Extracts: Anthelmintic, Antidiabetic, Antipyretic, and Antidiarrheal Potentials via Experimental, In Silico, and DFT Approaches

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
The methanolic extract of Syngonium podophyllum flower demonstrated significant anthelmintic, antidiabetic, antidiarrheal, and antipyretic effects across all in vitro and in vivo experimental models. Furthermore, in silico studies revealed that these phytoconstituents exhibit favorable pharmacokinetic properties, interact with key therapeutic target ...
Mahathir Mohammad, Nusrat Jahan Moon, Md. Hossain Rasel, Md. Anisul Islam, Nazmul Hasan Eshaque, Md. Jahirul Islam Mamun, Md. Zamil Hossain, Md. Mahmudul Hasan, Md. Tanvir Chowdhury, S. M. Moazzem Hossen   +9 more
wiley   +1 more source

Pathogenetic Mechanisms of Diarrhea in Children and Methods for Its Treatment

Zdorovʹe Rebenka, 2014
The paper presents the current views on the pathogenesis of acute intestinal infections in children and principles of therapy of diarrhea syndrome. Particular attention is paid to antisecretory therapy and the role of racecadotril in relieving diarrhea.
B.I. Krivuschev
doaj   +1 more source

Rethinking the AI Paradigm for Solubility Prediction of Drug‑Like Compounds with Dual‐Perspective Modeling and Experimental Validation

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Aqueous solubility governs drug delivery and bioavailability, yet its prediction remains challenging. Utilizing the largest curated dataset of drug‐like molecules, prediction models are constructed through dual‐perspective benchmarking. Stacking methods outperform advanced deep learning due to data constraints. These validated models enabled systematic
Qilin Zhu, Yuxin Qiu, Guzhong Chen, Wenyao Chen, Xiang Zhang, Zhiwen Qi, Xuezhi Duan, De Chen, Zhen Song   +8 more
wiley   +1 more source

Amyloidosis for the Gastroenterologist: A Comprehensive Systematic Review of Diagnosis and Management of Gastrointestinal Manifestations

Journal of Gastroenterology and Hepatology, Volume 40, Issue 12, Page 2842-2856, December 2025.
ABSTRACT Background Amyloidosis is a rare, multisystem disorder characterized by extracellular deposition of misfolded protein fibrils. Gastrointestinal (GI) amyloidosis is uncommon but under‐recognized due to nonspecific symptoms, but early diagnosis is critical to improve quality of life and prognosis.
Myo Jin Tang, Theng Yi Tay, Simon Gibbs, Ola Niewiadomski   +3 more
wiley   +1 more source

Development and Validation of a High Performance Liquid Chromatography Method for the Determination of Bromopride in the Presence of Methylparaben and Propylparaben in Pharmaceutical Formulations

SEPARATION SCIENCE PLUS, Volume 8, Issue 11, November 2025.
ABSTRACT A reversed‐phase high‐performance liquid chromatography method was developed and validated for the determination of bromopride (BROP) in the presence of methylparaben and propylparaben, using isocratic mode, C18 chromatographic column, mobile phase composed of acetonitrile and aqueous phase previously acidified with phosphoric acid to pH 3.5 ...
Francielli Gelatti Bortoly Carvalho, Patrícia Espinosa dos Santos, Elaine de Oliveira Araújo, Marcos Serrou do Amaral, Teófilo Fernando Mazon Cardoso, Nájla Mohamad Kassab   +5 more
wiley   +1 more source

Evaluating the cost utility of racecadotril for the treatment of acute watery diarrhea in children: the RAWD model

ClinicoEconomics and Outcomes Research, 2012
Tamlyn Anne Rautenberg1,2, Ute Zerwes1, Douglas Foerster3,4, Rick Aultman51Assessment in Medicine GmbH, Lörrach, Germany; 2Leeds Institute of Health Sciences, University of Leeds, Leeds, United Kingdom; 3Abbott Products Operations AG, Allschwil,
Rautenberg TA, Zerwes U, Foerster D, Aultman R   +3 more
doaj  

Hereditary angioedema in children: Review and practical perspective for clinical management

Pediatric Allergy and Immunology, Volume 35, Issue 12, December 2024.
Abstract Background Hereditary angioedema (HAE) in children has specific features and requires multidisciplinary management. Methods We performed a literature search and underwent in‐depth discussions to provide practical tools for physicians. Results HAE is a rare, life‐threatening genetic disorder.
Anne Pagnier, Angelina Dermesropian, Charlotte Kevorkian‐Verguet, Mélisande Bourgoin‐Heck, Cyrille Hoarau, Héloïse Reumaux, Frédérique Nugues, Christine Audouin‐Pajot, Sibylle Blanc, Aurélia Carbasse, Anne‐Laure Jurquet, Mélanie Voidey, Mona Villedieu, Laurence Bouillet, Isabelle Boccon‐Gibod   +14 more
wiley   +1 more source

Analysis of factors influencing the overall effect of racecadotril on childhood acute diarrhea. Results from a real-world and post-authorization surveillance study in Venezuela

Therapeutics and Clinical Risk Management, 2010
Jose ChacónOn behalf of the Racecadotril Post-authorization Record Group; Centro Clinico Profesional Caracas, Caracas, VenezuelaAbstract: Drug efficacy might differ from clinical trial results when performed in clinical daily conditions ...
Jose Chacón
doaj