Results 41 to 50 of about 746 (128)

Divergent functional isoforms drive niche specialisation for nutrient acquisition and use in rumen microbiome [PDF]

, 2017
Many microbes in complex competitive environments share genes for acquiring and utilising nutrients, questioning whether niche specialisation exists and if so, how it is maintained.
A McKenna, AG Doran, AK Kelly, AM Abdel-Hamid, B Langmead, B Temperton, C Camacho, C Toft, CA Carberry, CA Carberry, Christopher J Creevey, Ciara Carberry, CJ Creevey, CJ Creevey, CJ Creevey, CJ Creevey, D Marco, David Kenny, derWaltS van, DS Lundberg, E Nevo, F Sievers, FM Lauro, Francesco Rubino, H Teeling, J Nölling, J Purushe, J Ravachol, JB Russell, JE Koenig, JL Ellis, JP Gogarten, JT Simpson, K Yanagita, LD Tymensen, LM Steinberg, LM Williams, M Flythe, M Hess, M Kanehisa, M Mishra, M Poulsen, M Qi, Matthew S McCabe, MB Scholz, MD Servinsky, MD Young, ML Coleman, MW Baldwin, N Fonknechten, N Takahashi, NB Loughran, PH Janssen, PJ Turnbaugh, R Jain, RJ Wallace, S Anders, S Nelson-Sathi, S Otani, S Oxenbøll, S Powell, S Schloissnig, S Weckx, SA Huws, SA Huws, Sinéad M Waters, SR Eddy, SS Stewart, The Uniprot Consortium, WH Li, Y Benjamini, Z Yu   +71 more
core   +3 more sources

Proteomic analysis across aged tissues reveals distinct signatures and the crucial involvement of midgut barrier function in the regulation of aging

Aging Cell, Volume 24, Issue 1, January 2025.
Proteomic analysis reveals that instead of specific proteins, different tissues exhibit common dysregulated functional networks. Specifically, the integrity of the midgut barrier function is compromised during aging, which can be restored through the downregulation of the insulin receptor (InR).
Congying Zhang, Jinlong Wang, Tianzhao Yao, Jiaxin Hu, Feifei Sun, Chunlu Feng, Zhendong Sun, Yuzhuo Shao, Zhu Wang, Jiarui Wu, Yunpeng Huang   +10 more
wiley   +1 more source

Identification of the Cirratiomycin Biosynthesis Gene Cluster in Streptomyces Cirratus: Elucidation of the Biosynthetic Pathways for 2,3‐Diaminobutyric Acid and Hydroxymethylserine

Chemistry – A European Journal, Volume 30, Issue 28, May 17, 2024.
The cirratiomycin biosynthetic gene cluster was identified in Streptomyces cirratus by genome sequencing and gene inactivation. The biosynthesis of two nonproteinogenic amino acids was elucidated: (2S,3S)‐2,3‐diaminobutyric acid (DABA) is synthesized from threonine by four enzymes, CirQ, CirR, CirS and CirB, and α‐(hydroxymethyl)serine (HMSer) is ...
Shunki Sakata, Jiafeng Li, Yoko Yasuno, Tetsuro Shinada, Kazuo Shin‐ya, Yohei Katsuyama, Yasuo Ohnishi   +6 more
wiley   +1 more source

Lipases como biocatalisadores na epoxidação químio-enzimática do cicloexeno [PDF]

, 2004
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Físicas e Matemáticas. Curso de Química.As enzimas, são catalisadores protéicos, que em condições ótimas de temperatura e pH aceleram as reações químicas.
BITENCOURT, Thiago Bergler
core  

Exploration and characterization of the LarA superfamily: a superfamily of 2-hydroxy acid racemases and epimerases

, 2023
ɑ-Hydroxy acids are organic compounds omnipresent in the living world and can be considered as building blocks in organic synthesis. However, racemases and epimerases of ɑ-hydroxy acids are poorly known. Among them, lactate racemase (LarA) was shown to require a unique nickel-containing cofactor, the nickel-pincer nucleotide(NPN.
Urdiain-Arraiza, Julian, Novel Enzymes 2023   +1 more
openaire   +1 more source

Experimental evidence of d‐glutamate racemase activity in the uncultivated bacterium Candidatus Saccharimonas aalborgensis

Environmental Microbiology, Volume 26, Issue 4, April 2024.
Bacteria from the uncultivated Candidate Phyla Radiation (CPR) dominate various habitats, despite possessing limited metabolic capacities. These bacteria have incomplete sets of enzymes, which include pathways for producing structures that are essential for life. This supports the hypothesis of moonlighting activities in the remaining enzymes.
Marcos Peñalver, Alberto Paradela, César Palacios‐Cuéllar, M. Graciela Pucciarelli, Francisco García‐del Portillo   +4 more
wiley   +1 more source

Mechanistic studies of PLP-independent racemases [PDF]

, 2018
Pyridoxal phosphate (PLP)-independent racemases, enzymes that are cofactor and metal free invert, the configuration at the α-carbon of amino acids. In nature, diaminopimelate epimerase (DapF), glutamate racemase (GluR), aspartate racemase (AspR), proline
Ahn, Yeong-Chan
core   +2 more sources

Purification and Characterization of Novel “2-Arylpropionyl-CoA Epimerases” from Rat Liver Cytosol and Mitochondria [PDF]

, 1993
Investigation on the biochemical isomerization of ibuprofen led us to the successful purification of “2-arylpropionyl-CoA epimerase” from rat liver cytosol and mitochondria.
Chen, Ching-Shih, Shieh, Woan-Ru
core   +1 more source

Is EC class predictable from reaction mechanism? [PDF]

, 2012
We thank the Scottish Universities Life Sciences Alliance (SULSA) and the Scottish Overseas Research Student Awards Scheme of the Scottish Funding Council (SFC) for financial support.Background: We investigate the relationships between the EC (Enzyme ...
A Statnikov, AG McDonald, BV Dasarathy, BW Matthews, C Andreini, C Andreini, DARS Latino, DE Almonacid, DE Almonacid, GL Holliday, GL Holliday, GL Holliday, GL Holliday, GL Holliday, GL Holliday, GL Holliday, GL Holliday, IUBMB, J Gorodkin, J Menke, John BO Mitchell, JW Torrance, K Astikainen, KM Borgwardt, L Breiman, L De Ferrari, LD Hughes, M Aizerman, M Kanehisa, M Leber, N Furnham, N Nagano, N Nagano, Neetika Nath, NM O'Boyle, O Sacher, PC Babbitt, PD Dobson, R Lowe, RD Uriarte, SA Rahman, SCH Pegg, SCH Pegg, T Bray, T Bylander, V Egelhofer, VN Vapnik, WS Noble, X Hu, Y Yamanishi   +49 more
core   +4 more sources

Preparação de dibenzalacetonas e estudos de reações de bio-hidrogenação mediada por Saccharomyces cerevisiae  [PDF]

, 2009
TCC (graduação) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Curso de Química.Neste trabalho foram sintetizados derivados de benzaldeídos com acetona denominados de dibenzalacetonas constituídas pelos substituintes ...
Maguerroski, Kamila dos Santos
core