Results 31 to 40 of about 746 (128)

Structures of two LarA‐like nickel‐pincer nucleotide cofactor‐utilizing enzymes with a single catalytic histidine residue

Protein Science, Volume 34, Issue 12, December 2025.
Abstract The nickel‐pincer nucleotide (NPN) cofactor catalyzes the racemization/epimerization of α‐hydroxy acids in enzymes of the LarA family. The established proton‐coupled hydride transfer mechanism requires two catalytic histidine residues that alternately act as general acids and general bases. Notably, however, a fraction of LarA homologs (LarAHs)
Santhosh Gatreddi, Sundharraman Subramanian, Dexin Sui, Tianqi Wang, Julian Urdiain‐Arraiza, Benoît Desguin, Robert P. Hausinger, Kristin N. Parent, Jian Hu   +8 more
wiley   +1 more source

Chiral Biomarkers and Microfossils in Carbonaceous Meteorites [PDF]

Homochirality of the biomolecules (D-sugars of DNA and RNA and L-amino acids of proteins) is a fundamental property of all life on Earth. Abiotic mechanisms yield racemic mixtures (D/L=1) of chiral molecules and after the death of an organism, the ...
Hoover, Richard B.
core   +2 more sources

Intramolecular epistasis correlates with divergence of specificity in promiscuous and bifunctional NSAR/OSBS enzymes

Protein Science, Volume 34, Issue 5, May 2025.
Abstract Understanding the functions and evolution of specificity‐determining residues is essential for improving strategies to predict and design enzyme functions. Whether the function of an amino acid residue is retained during evolution depends on intramolecular epistasis, which occurs when the same residue contributes to different phenotypes in ...
Dat P. Truong, Roopa Dharmatti, Dylan Suriadinata, Jamison Huddleston, Rebecca Skouby, Gladys Owusu Addo, Mingzhao Zhu, Anjana Delpe Acharige, Reethu Sankari Bayana, Cristian Davila, Susan C. Fults, Frank M. Raushel, Kenneth G. Hull, Daniel Romo, Margaret E. Glasner   +14 more
wiley   +1 more source

Protein crystallographic studies to understand the reaction mechanism of enzymes: α-methylacyl-CoA racemase and argininosuccinate lyase [PDF]

, 2006
Enzymes catalyze chemical changes in biological systems. Therefore, to understand the chemistry of living systems, it is important to understand the enzyme structure and the chemistry of the enzyme’s functional groups which are involved in catalysis.
Bhaumik, Prasenjit
core  

Imobilização de lipases em filmes de poli(álcool vinílico) e carbOximetilcelulose [PDF]

, 2003
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Físicas e Matemáticas. Curso de Química.As enzimas em sua maioria são catalisadores de natureza protéica. São versáteis, existindo um processo enzimático equivalente para vários
NUERNBERG, Giselle de Boit
core  

EXPLORING THE BIOSYNTHESIS, FUNCTION, AND DETECTION OF THE NICKEL-PINCER NUCLEOTIDE COFACTOR [PDF]

Thesis (Ph.D.)--Michigan State University. Chemistry - Doctor of Philosophy, 2024The nickel-pincer nucleotide (NPN) cofactor is an organometallic cofactor critical for the activity of lactate racemase (LarA) and other racemases and epimerases.
Nevarez, Jorge Luis
core   +2 more sources

Comparative Transcriptomic Analysis of AtBBX29 Transgenic and Wild Type Sugarcane Exposed to Drought Stress

Physiologia Plantarum, Volume 177, Issue 3, May/June 2025.
ABSTRACT Previously, we produced drought‐tolerant transgenic sugarcane plants that overexpressed the AtBBX29 gene, which encodes a transcription factor (TF) B‐box protein. These plants displayed delayed senescence, were able to maintain photosynthesis, and accumulated high levels of antioxidants and osmolytes when exposed to water deficit stress ...
Christell van der Vyver, Preetom Regon, Kristen Fulton, Sanjib K. Panda   +3 more
wiley   +1 more source

Estudo da atividade enzimática de Lacase imobilizada quitosana [PDF]

, 2003
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Físicas e Matemáticas. Curso de Química.Este trabalho teve como principal objetivo caracterização da enzima Lacase.
CRUZ JÚNIOR, Américo
core  

Developing the WCRF International/University of Bristol methodology for identifying and carrying out systematic reviews of mechanisms of exposure-cancer associations [PDF]

, 2017
Background: Human, animal, and cell experimental studies; human biomarker studies; and genetic studies complement epidemiologic findings and can offer insights into biological plausibility and pathways between exposure and disease, but methods for ...
Borwick, Catherine, Emmett, Pauline, Gardner, Mike, Gaunt, Tom, Harrison, Sean, Higgins, Julian, Holly, Jeff M. P., Jeffreys, Mona, Lennon, Rosie, Lewis, Sarah, Martin, Richard, Mitrou, Giota, Northstone, Kate, Perks, Claire, Rinaldi, Sabina, Tan, Vanessa, Thomas, Steve, Thompson, Rachel, Turner, Suzanne, Wiseman, Martin   +19 more
core   +2 more sources

Liquid Chromatographic and Capillary Electromigration Techniques for the Analysis of Azole Antifungals

Journal of Separation Science, Volume 48, Issue 4, April 2025.
ABSTRACT Since the introduction of azoles as antifungals in 1979, they gradually gained a spotlight in both medicinal and industrial fields. Other than being the leading antifungal medicinal drug agents, azoles have also been a major pesticide in agricultural industry.
Tuuliina Tuominen, Dumidu Perera, Giacomo Russo, Susanne K. Wiedmer   +3 more
wiley   +1 more source