Results 11 to 20 of about 594 (100)
Structural Basis for the Catalysis and Substrate Specificity of a LarA Racemase with a Broad Substrate Spectrum. [PDF]
ACS CatalThe LarA family consists of diverse racemases/epimerases that interconvert the diastereomers of α-hydroxyacids by using a nickel-pincer nucleotide (NPN) cofactor.
Gatreddi S +4 more
europepmc +2 more sources
Journal of Comparative Neurology, Volume 530, Issue 11, Page 1773-1949, August 2022., 2022 By using a genetically modified mouse model and viral tracing approaches, we mapped both the anterograde and the retrograde projections of a subpopulation of neurons in the anterior paraventricular thalamic nucleus, molecularly defined by the expression of glucokinase (GckaPVT).
Sevasti Gaspari +4 more
wiley +1 more source
(S)‐3‐aminopiperidine‐2,6‐dione is a biosynthetic intermediate of microbial blue pigment indigoidine
mLife, Volume 1, Issue 2, Page 146-155, June 2022., 2022 Abstract The biosynthetic investigations of microbial natural products continuously provide powerful biocatalysts for the preparation of valuable chemicals. Practical methods for preparing (S)‐3‐aminopiperidine‐2,6‐dione (2), the pharmacophore of thalidomide (1) and its analog drugs, are highly desired.
Zhilong Zhang +7 more
wiley +1 more source
リボソームペプチドの複数アミノ酸残基を異性化する新規エピメラーゼ [PDF]
, 2023 Salinipeptins, grisemycin, and cypemycin are ribosomally synthesized and post-translationally modified peptides (RiPPs). Among these, salinipeptins were reported to comprise 22 amino acid residues with multiple D-amino acids, and its biosynthetic gene ...
Xiao, Wanlu
core +1 more source
Advances in Key Drug Target Identification and New Drug Development for Tuberculosis
BioMed Research International, Volume 2022, Issue 1, 2022., 2022 Tuberculosis (TB) is a severe infectious disease worldwide. The increasing emergence of drug‐resistant Mycobacterium tuberculosis (Mtb) has markedly hampered TB control. Therefore, there is an urgent need to develop new anti‐TB drugs to treat drug‐resistant TB and shorten the standard therapy.
Jie Mi +3 more
wiley +1 more source
Advances of capillary electrophoresis enantioseparations in pharmaceutical analysis (2017–2020)
ELECTROPHORESIS, Volume 42, Issue 17-18, Page 1709-1725, September 2021., 2021 Abstract Capillary electrophoresis is a powerful technique for the analysis of polar chiral compounds and has been widely accepted for analytical enantioseparations of drug compounds in pharmaceuticals and biological media. In addition, many mechanistic studies have been conducted in an attempt to rationalize enantioseparations in combination with ...
Sulaiman Krait +2 more
wiley +1 more source
Uncovering a superfamily of nickel-dependent hydroxyacid racemases and epimerases
, 2021 Isomerization reactions are fundamental in biology. Lactate racemase, which isomerizes L- and D-lactate, is composed of the LarA protein and a nickel-containing cofactor, the nickel-pincer nucleotide (NPN).
World Microbe Forum +1 more
core +1 more source
, 2023 The nickel–pincer nucleotide (NPN) cofactor discovered in lactate racemase from Lactiplantibacillus plantarum (LarALp) is essential for the activities of racemases/epimerases in the highly diverse LarA superfamily.
Jian Hu +7 more
core +1 more source
, 2023 ɑ-Hydroxy acids are organic compounds omnipresent in the living world and can be considered as building blocks in organic synthesis. However, racemases and epimerases of ɑ-hydroxy acids are poorly known.
Novel Enzymes 2023 +1 more
core
Ecology and Evolution, Volume 16, Issue 4, April 2026.Transcriptomic data indicates that gene expression responses underlying developmental thermal plasticity differ from those of short‐term acclimation temperature in the butterfly Pieris rapae. We also identify a small subset of genes for which expression levels depend on the interaction of developmental temperature and short‐term acclimation temperature.
Samantha L. Sturiale +6 more
wiley +1 more source