Results 11 to 20 of about 746 (128)

Unveiling 14 novel 2-hydroxy acid racemization and epimerization reactions in the lactate racemase superfamily. [PDF]

J Biol Chem
Urdiain-Arraiza J, Vandenberghe A, Dimitrova G, Desguin B.   +3 more
europepmc   +2 more sources

Structural and molecular characterization of paraventricular thalamic glucokinase‐expressing neuronal circuits in the mouse

Journal of Comparative Neurology, Volume 530, Issue 11, Page 1773-1949, August 2022., 2022
By using a genetically modified mouse model and viral tracing approaches, we mapped both the anterograde and the retrograde projections of a subpopulation of neurons in the anterior paraventricular thalamic nucleus, molecularly defined by the expression of glucokinase (GckaPVT).
Sevasti Gaspari, Simon Quenneville, Ana Rodriguez Sanchez‐Archidona, Bernard Thorens, Sophie Croizier   +4 more
wiley   +1 more source

(S)‐3‐aminopiperidine‐2,6‐dione is a biosynthetic intermediate of microbial blue pigment indigoidine

mLife, Volume 1, Issue 2, Page 146-155, June 2022., 2022
Abstract The biosynthetic investigations of microbial natural products continuously provide powerful biocatalysts for the preparation of valuable chemicals. Practical methods for preparing (S)‐3‐aminopiperidine‐2,6‐dione (2), the pharmacophore of thalidomide (1) and its analog drugs, are highly desired.
Zhilong Zhang, Pengwei Li, Min Wang, Yan Zhang, Bian Wu, Yong Tao, Guohui Pan, Yihua Chen   +7 more
wiley   +1 more source

The Unexpected Advantages of Using D-Amino Acids for Peptide Self- Assembly into Nanostructured Hydrogels for Medicine [PDF]

, 2016
Self-assembled peptide hydrogels have brought innovation to the medicinal field, not only as responsive biomaterials but also as nanostructured therapeutic agents or as smart drug delivery systems.
Marchesan, Silvia, Melchionna, Michele, Styan, Katie E   +2 more
core   +1 more source

Advances in Key Drug Target Identification and New Drug Development for Tuberculosis

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
Tuberculosis (TB) is a severe infectious disease worldwide. The increasing emergence of drug‐resistant Mycobacterium tuberculosis (Mtb) has markedly hampered TB control. Therefore, there is an urgent need to develop new anti‐TB drugs to treat drug‐resistant TB and shorten the standard therapy.
Jie Mi, Wenping Gong, Xueqiong Wu, Atef M. Al Attar   +3 more
wiley   +1 more source

Structure of the first representative of Pfam family PF04016 (DUF364) reveals enolase and Rossmann-like folds that combine to form a unique active site with a possible role in heavy-metal chelation. [PDF]

, 2010
The crystal structure of Dhaf4260 from Desulfitobacterium hafniense DCB-2 was determined by single-wavelength anomalous diffraction (SAD) to a resolution of 2.01 Å using the semi-automated high-throughput pipeline of the Joint Center for Structural ...
Abdubek, Polat, Aravind, L, Astakhova, Tamara, Axelrod, Herbert L, Bakolitsa, Constantina, Carlton, Dennis, Chiu, Hsiu Ju, Clayton, Thomas, Deacon, Ashley M, Deller, Marc C, Duan, Lian, Elsliger, Marc André, Feuerhelm, Julie, Godzik, Adam, Grant, Joanna C, Han, Gye Won, Hodgson, Keith O, Jaroszewski, Lukasz, Jin, Kevin K, Klock, Heath E, Knuth, Mark W, Kozbial, Piotr, Krishna, S Sri, Kumar, Abhinav, Lesley, Scott A, Marciano, David, McMullan, Daniel, Miller, Mitchell D, Morse, Andrew T, Nigoghossian, Edward, Okach, Linda, Reyes, Ron, Rife, Christopher L, van den Bedem, Henry, Weekes, Dana, Wilson, Ian A, Wooley, John, Xu, Qingping   +37 more
core   +3 more sources

Advances of capillary electrophoresis enantioseparations in pharmaceutical analysis (2017–2020)

ELECTROPHORESIS, Volume 42, Issue 17-18, Page 1709-1725, September 2021., 2021
Abstract Capillary electrophoresis is a powerful technique for the analysis of polar chiral compounds and has been widely accepted for analytical enantioseparations of drug compounds in pharmaceuticals and biological media. In addition, many mechanistic studies have been conducted in an attempt to rationalize enantioseparations in combination with ...
Sulaiman Krait, Mari‐Luiza Konjaria, Gerhard K. E. Scriba   +2 more
wiley   +1 more source

Molecular and Structural Discrimination of Proline Racemase and Hydroxyproline-2-Epimerase from Nosocomial and Bacterial Pathogens

PLoS ONE, 2007
The first eukaryotic proline racemase (PRAC), isolated from the human Trypanosoma cruzi pathogen, is a validated therapeutic target against Chagas' disease. This essential enzyme is implicated in parasite life cycle and infectivity and its ability to trigger host B-cell nonspecific hypergammaglobulinemia contributes to parasite evasion and persistence.
Goytia, Maira, Chamond, Nathalie, Cosson, Alain, Coatnoan, Nicolas, Hermand, Daniel, Berneman, Armand, Minoprio, Paola   +6 more
openaire   +4 more sources

Identification and Characterization of Bifunctional Proline Racemase/Hydroxyproline Epimerase from Archaea: Discrimination of Substrates and Molecular Evolution

PLOS ONE, 2015
Proline racemase (ProR) is a member of the pyridoxal 5'-phosphate-independent racemase family, and is involved in the Stickland reaction (fermentation) in certain clostridia as well as the mechanisms underlying the escape of parasites from host immunity in eukaryotic Trypanosoma.
Seiya Watanabe, Yoshiaki Tanimoto, Hisashi Nishiwaki, Yasuo Watanabe   +3 more
openaire   +4 more sources

Phylogenetic and syntenic data support a single horizontal transference to a Trypanosoma ancestor of a prokaryotic proline racemase implicated in parasite evasion from host defences [PDF]

, 2015
\ud \ud Background\ud Proline racemase (PRAC) enzymes of Trypanosoma cruzi (TcPRAC), the agent of Chagas disease, and Trypanosoma vivax (TvPRAC), the agent of livestock trypanosomosis, have been implicated in
Alves, João M P, Buck, Gregory A, Caballero, Zuleima C, Camargo, Erney P, Costa-Martins, Andre G, Ferreira, Robson C, Minoprio, Paola, Serrano, Myrna G, Teixeira, Marta M G   +8 more
core   +5 more sources