Results 21 to 30 of about 632 (113)

Structural and molecular characterization of paraventricular thalamic glucokinase‐expressing neuronal circuits in the mouse

Journal of Comparative Neurology, Volume 530, Issue 11, Page 1773-1949, August 2022., 2022
By using a genetically modified mouse model and viral tracing approaches, we mapped both the anterograde and the retrograde projections of a subpopulation of neurons in the anterior paraventricular thalamic nucleus, molecularly defined by the expression of glucokinase (GckaPVT).
Sevasti Gaspari, Simon Quenneville, Ana Rodriguez Sanchez‐Archidona, Bernard Thorens, Sophie Croizier   +4 more
wiley   +1 more source

(S)‐3‐aminopiperidine‐2,6‐dione is a biosynthetic intermediate of microbial blue pigment indigoidine

mLife, Volume 1, Issue 2, Page 146-155, June 2022., 2022
Abstract The biosynthetic investigations of microbial natural products continuously provide powerful biocatalysts for the preparation of valuable chemicals. Practical methods for preparing (S)‐3‐aminopiperidine‐2,6‐dione (2), the pharmacophore of thalidomide (1) and its analog drugs, are highly desired.
Zhilong Zhang, Pengwei Li, Min Wang, Yan Zhang, Bian Wu, Yong Tao, Guohui Pan, Yihua Chen   +7 more
wiley   +1 more source

Advances in Key Drug Target Identification and New Drug Development for Tuberculosis

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
Tuberculosis (TB) is a severe infectious disease worldwide. The increasing emergence of drug‐resistant Mycobacterium tuberculosis (Mtb) has markedly hampered TB control. Therefore, there is an urgent need to develop new anti‐TB drugs to treat drug‐resistant TB and shorten the standard therapy.
Jie Mi, Wenping Gong, Xueqiong Wu, Atef M. Al Attar   +3 more
wiley   +1 more source

Advances of capillary electrophoresis enantioseparations in pharmaceutical analysis (2017–2020)

ELECTROPHORESIS, Volume 42, Issue 17-18, Page 1709-1725, September 2021., 2021
Abstract Capillary electrophoresis is a powerful technique for the analysis of polar chiral compounds and has been widely accepted for analytical enantioseparations of drug compounds in pharmaceuticals and biological media. In addition, many mechanistic studies have been conducted in an attempt to rationalize enantioseparations in combination with ...
Sulaiman Krait, Mari‐Luiza Konjaria, Gerhard K. E. Scriba   +2 more
wiley   +1 more source

Irreversible Inactivation of Lactate Racemase by Sodium Borohydride Reveals Reactivity of the Nickel–Pincer Nucleotide Cofactor

, 2023
The nickel–pincer nucleotide (NPN) cofactor discovered in lactate racemase from Lactiplantibacillus plantarum (LarALp) is essential for the activities of racemases/epimerases in the highly diverse LarA superfamily.
Jian Hu, Santhosh Gatreddi, Dexin Sui (1945780), Dexin Sui, Robert P. Hausinger (30028), Santhosh Gatreddi (14371469), Jian Hu (31535), Robert P. Hausinger   +7 more
core   +1 more source

A new amino acid racemase with threonine alpha-epimerase activity from Pseudomonas putida: purification and characterization

Journal of Bacteriology, 1993
We have found that Pseudomonas putida ATCC 17642 cells grown in a medium containing D-threonine as the sole nitrogen source produce an enzyme that catalyzes epimerization of threonine. Proton nuclear magnetic resonance analysis of the enzyme reaction in deuterium oxide clearly showed epimerization from L- to D-allo-threonine and also from D- to L-allo ...
Y H, Lim, K, Yokoigawa, N, Esaki, K, Soda   +3 more
openaire   +3 more sources

Different Transcriptional Responses to Developmental Versus Short‐Term Acclimation Temperatures in Pieris rapae

Ecology and Evolution, Volume 16, Issue 4, April 2026.
Transcriptomic data indicates that gene expression responses underlying developmental thermal plasticity differ from those of short‐term acclimation temperature in the butterfly Pieris rapae. We also identify a small subset of genes for which expression levels depend on the interaction of developmental temperature and short‐term acclimation temperature.
Samantha L. Sturiale, Lorrie Le Yi He, Katherine H. Malinski, Christopher S. Willett, Joel G. Kingsolver, Leslie Ries, Peter A. Armbruster   +6 more
wiley   +1 more source

Chlamydia trachomatis dapF Encodes a Bifunctional Enzyme Capable of Both d -Glutamate Racemase and Diaminopimelate Epimerase Activities

mBio, 2018
ABSTRACT Peptidoglycan is a sugar/amino acid polymer unique to bacteria and essential for division and cell shape maintenance. The d -amino acids that make up its cross-linked stem peptides are not abundant in nature and must be synthesized by bacteria de novo . d
George Liechti, Raghuveer Singh, Patricia L. Rossi, Miranda D. Gray, Nancy E. Adams, Anthony T. Maurelli   +5 more
openaire   +3 more sources

Divergent Fates of Hardjo Leptospires: Early Transcriptomic Response of Leptospira interrogans in an Ovine Dialysis Membrane Chamber Model

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Leptospira interrogans serovar Hardjo and Leptospira borgpetersenii serovar Hardjo are major bovine‐ and ovine‐adapted pathogens that differ markedly in genome content. To investigate early events during host exposure, we compared the survival of both species using an ovine peritoneal dialysis membrane chamber (DMC) model, which exposes leptospires to ...
Klaudia Dubniewicz, Laura Pardyak, Patrycja Walczak, Agnieszka Pietsch-Fulbiszewska, Artur Gurgul, Igor Jasielczuk, Tomasz Szmatoła, Zbigniew J. Arent, Yong-guo Cao   +8 more
wiley   +1 more source

Determinants of Catalytic Power and Ligand Binding in Glutamate Racemase

, 2016
Glutamate racemases (EC 5.1.1.3) catalyze the cofactor-independent stereoinversion of d- and l-glutamate and are important for viability in several Gram-negative and -positive bacteria.
Katherine L. Pankow (2307292), Steven R. Blanke (47138), M. Ashley Spies (1300746), Dylan Dodd (487346), Joseph G. Reese (2380726), Jerome Baudry (442664)   +5 more
core   +1 more source