Results 121 to 130 of about 89,874 (280)
Journal of Affective Disorders ReportsBackground and aim: Intranasal racemic ketamine is an off-label alternative for treatment-resistant depression (TRD), offering a non-invasive and compared to esketamine less expensive option. However, its efficacy and safety in outpatient settings remain
Jan Sarlon +4 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.Recent theoretical efforts to elucidate the origin of enantioselectivity in transition metal‐catalyzed propargylic substitution reactions are highlighted in this review. ABSTRACT In recent years, asymmetric catalytic propargylic substitution reactions have undergone remarkable development, enabling the construction of chiral carbon centers adjacent to ...
Ken Sakata, Yoshiaki Nishibayashi
wiley +1 more source
Chiral Ionic Liquids: Synthesis, Properties, and Enantiomeric Recognition [PDF]
, 2008 We have synthesized a series of structurally novel chiral ionic liquids which have a either chiral cation, chiral anion, or both. Cations are an imidazolium group, while anions are based on a borate ion with spiral structure and chiral substituents. Both
Lindeman, Sergey V. +2 more
core +1 more source
Synthesis and Characterization of Carbazole‐Containing Aza[7]helicenes
Chemistry – A European Journal, EarlyView.Double ortho fusion led to different aza[7]helicene frameworks showing strong acidochromic behavior, singlet excited energies being more than twice the triplet energy, and high racemization barriers, allowing chiral resolution and ECD measurements. ABSTRACT Azahelicenes have attracted significant interest due to their intrinsic axial chirality and ...
Inka Marten +2 more
wiley +1 more source
Bifunctional Photocatalysts: Exploiting Proximity for Enhanced Reaction Performance
Chemistry – A European Journal, EarlyView.This review covers the application of the bifunctional approach to photocatalysis as a means to attain (enhanced) enantioselectivity, and, more in general, as a strategy to enhance the catalytic performance through an effective use of short‐lived reaction intermediates.
Luigi Dolcini +3 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.In situ phenoxide formation at the benzene terminus triggers room‐temperature conversion of thia[6]helicene S,S‐dioxides to coronene. The solubility contrast drives product precipitation, enabling isolation by simple filtration. This pericyclic annulation between the helical termini provides direct access to coronene‐type planar architectures ...
Kaito Seino, Takashi Murase
wiley +1 more source
Racemization and Epimerization [PDF]
Science, 1971 W T, Smith, K A, Kvenvolden
openaire +2 more sources
Planar Chirality Controls Diastereotopicity in [2.2]Paracyclophanyl Cyclopropenes
Chemistry – A European Journal, EarlyView.In this work, we report the synthesis of [2.2]paracyclophane‐substituted cyclopropenes via rhodium‐catalyzed cyclopropenation using a pCp‐derived carbene precursor. The planar chiral framework induces diastereotopic differentiation of otherwise equivalent alkyl substituents, which is reflected in their 1H NMR spectra.
Tilman Köhler +3 more
wiley +1 more source
Bayesian Optimization of Solvent‐Free Thermal Amidation via Reactive Extrusion
Chemistry – A European Journal, EarlyView.Thermal amidation between a carboxylic acid and an amine was successfully conducted in an extruder in the absence of solvent, coupling agent, or catalyst, relying on an adapted Bayesian Optimization protocol. Active pharmaceutical ingredient moclobemide was synthesized on a larger scale, achieving excellent yield and low Process Mass Intensity (PMI ...
Matthieu Lavayssiere +2 more
wiley +1 more source
Stable Cyclic Peterson Olefination Intermediates
Chemistry – A European Journal, EarlyView.We present the first synthesis and characterization of several stable cyclic Peterson olefination intermediates with four carbon bonded substituents at the silicon. The cyclic 1,2‐oxasiletanide intermediates were synthesized via the reaction of an α‐silyl carbanion with various ketones.
Julia Landwehrmann +3 more
wiley +1 more source