Results 231 to 240 of about 89,874 (280)

Novel Silver(I) and Gold(I) N‐Heterocyclic Carbene Complexes Induce ROS‐Dependent Autophagic Cell Death in Human Hepatoma Cell Line HepG2

Chemical Biology &Drug Design, Volume 107, Issue 4, April 2026.
In this research work, the cytotoxicity of eight sulfonated silver(I) and gold(I) N‐heterocyclic carbene (NHC) complexes—four newly synthesized—was evaluated against human liver cancer cells. Two compounds showed selectivity for cancer cells, inducing ROS‐dependent autophagic cell death via AKT/mTOR pathway inhibition without triggering apoptosis ...
Rocchina Miglionico, Francesco Viceconte, Maria Francesca Armentano, Annaluisa Mariconda, Ilaria Nigro, Pasquale Longo, Faustino Bisaccia   +6 more
wiley   +1 more source

Esketamine Nasal Spray: Mechanism of Action, Clinical, and Translational Science

Clinical and Translational Science, Volume 19, Issue 4, April 2026.
ABSTRACT Major depressive disorder (MDD) imposes a substantial burden worldwide, with treatment‐resistant depression (TRD) and major depressive disorder with acute suicidal ideation or behavior (MDSI) representing two of the most severe clinical challenges.
Matthijs W. van Hoogdalem, Dong‐Jing Fu, Wayne C. Drevets, Peter N. Zannikos   +3 more
wiley   +1 more source

Catalytic asymmetric synthesis of (N, N)- spiroketal via Pd-catalyzed enantioconvergent aminocarbonylation and dearomative nucleophilic aza-addition. [PDF]

Nat Commun
Su L, Gao S, Liu J.
europepmc   +1 more source

Performance of Beef Cattle Under Grazing as Affected by Urochloa decumbens Cultivars

Grass and Forage Science, Volume 81, Issue 2, April-June 2026.
ABSTRACT Testing animal performance under grazing is fundamental to determine the potential of recently released, high‐yielding Urochloa decumbens hybrids. The objective was to evaluate the weight gain of young bulls grazing on pastures of U. decumbens cultivars Basilisk, BRS Carinás, and BRS Poraitê, as well as to assess the nutritive value and plant ...
Gustavo José Braga, Allan Kardec Braga Ramos, Marcelo Ayres Carvalho, Claudio Takao Karia, Sanzio Carvalho Lima Barrios   +4 more
wiley   +1 more source

The Effect of a Single Trifluoromethyl Substituent on the Reactivity of Chelating <i>C</i>₂ and <i>C</i>_s-Symmetric Bis(alkoxide) Ligands on a Terphenyl Platform. [PDF]

Inorg Chem
Jayasundara R, Kulathungage LW, Baillie BJ, Ward CL, Lord RL, Groysman S.   +5 more
europepmc   +1 more source

Tailoring Electronic Properties of Precision Graphene Nanoribbons via Nanopore Engineering

Angewandte Chemie, Volume 138, Issue 14, 27 March 2026.
Novel porous graphene nanoribbons incorporating [18]annulene nanopores, together with a nonporous GNR of identical width, have been synthesized. Spectroscopic and theoretical analyses reveal that nanopore incorporation effectively tunes their electronic properties by enlarging the bandgap, reducing charge‐carrier mobility, and modulating exciton ...
Kun Liu, Guanzhao Wen, Gianluca Serra, Nicolás Arisnabarreta, Hongde Yu, Andrea Lucotti, Yarden Peleg Walg, Hartmut Komber, Zhen‐Lin Qiu, Qing‐Song Deng, Ran He, Wenhui Niu, Thomas Heine, Eike Brunner, Mischa Bonn, Steven De Feyter, Matteo Tommasini, Hai I. Wang, Ji Ma, Xinliang Feng   +19 more
wiley   +1 more source

Unique halogen-π association detected in single crystals of C-N atropisomeric <i>N</i>-(2-halophenyl)quinolin-2-one derivatives and the thione analogue. [PDF]

Beilstein J Org Chem
Uchibori M, Murate N, Shima K, Sakagami T, Kanehisa K, Richards GJ, Hori A, Kitagawa O.   +7 more
europepmc   +1 more source

Cardiovascular effects of hypertonic lactate solutions: acid-base or metabolic cause, or both? Authors' reply. [PDF]

Crit Care
Berg-Hansen K, Pedersen MGB, Gopalasingam N, Hørsdal OK, Møller N, Wiggers H, Nielsen R.   +6 more
europepmc   +1 more source

Enantioselective Intramolecular C-H Alkylation Catalyzed by a Nonsymmetric Chiral Cobalt Porphyrin. [PDF]

J Am Chem Soc
Buchelt C, Breitenlechner S, Zuber J, Huber SM, Bach T.   +4 more
europepmc   +1 more source