Enabling Direct Preferential Crystallization in a Stable Racemic Compound System. [PDF]
Molecular Pharmaceutics, 2019 The preparative resolution by preferential crystallization (PC) of proxyphylline has been achieved despite the existence of a stable racemic compound. This is enabled through the careful selection of a solvent in which both the racemic compound and the ...
Lina C. Harfouche +5 more
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Deracemization of a Racemic Compound by Using Tailor-Made Additives. [PDF]
Chemistry – A European Journal, 2018 AbstractViedma ripening is a process that combines abrasive grinding of a slurry of crystals with solution‐phase racemization, resulting in solid‐phase deracemization. One of the major disadvantages of Viedma ripening is that the desired compound needs to crystallize as a racemic conglomerate, accounting for only 5–10 % of all chiral molecules. Herein,
A. Engwerda +5 more
semanticscholar +4 more sources
Asymmetric amplification in amino acid sublimation involving racemic compound to conglomerate conversion. [PDF]
Chemical Communications, 2011 A straightforward unprecedented sublimation protocol that reveals both conversion of a racemic compound into a racemic conglomerate and subsequent enantioenrichment has been developed for the proteinogenic amino acid valine.
C. Viedma +4 more
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A New Method of Resolving a Racemic Compound
Nature, 1938 WE have recently developed a new method of resolving a racemic compound by selective adsorption, and the results we have obtained, already published in the Praktika of the Academy of Athens (April 1938), agree in the main with similar experiments of G. M. Henderson and Dr. H. Gordon Rule1.
G. Karagunis, G. Coumoulos
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A Newly Discovered Racemic Compound of Pioglitazone Hydrochloride Is More Stable than the Commercial Conglomerate. [PDF]
Cryst Growth Des, 2017 Zhang C, Matzger AJ.
europepmc +2 more sources
Formation of racemic compound crystals by mixing of two enantiomeric crystals in the solid state. Liquid transport of molecules from crystal to crystal [PDF]
, 1997 Mixing of powdered (-)- and (+)-enantiomer crystals in the solid state gives crystals of the racemic compound. This racemic crystal formation was followed by IR spectral measurement of a 1∶1 mixture of (-)- and (+)-enantiomer crystals as a Nujol mull.
F. Toda +5 more
semanticscholar +3 more sources
Use of Conglomerates Mixed Crystals to Deracemize a Stable Racemic-Compound-Forming System.
Chemistry, 2023 Deracemization extended to racemic-compound-forming systems is demonstrated. We present here the first results of an alternative for the resolution of systems that exhibit a stable racemic compound but also a closely related conglomerate-forming system ...
Clément Pinètre +6 more
semanticscholar +1 more source
Biomimetics, 2023 This study focuses on developing and evaluating two novel enantioselective biomimetic models for the active centers of oxidases (ascorbate oxidase and catalase).
Didier Gómez +4 more
doaj +1 more source
Simultaneous Chiral Resolution of Two Racemic Compounds by Preferential Cocrystallization** [PDF]
Angewandte Chemie International Edition, 2021 Abstract We tap into an unexplored area of preferential crystallization, being the first to develop simultaneous chiral resolution of two racemic compounds by preferential cocrystallization. We highlight how the two racemic compounds RS ‐mandelic acid (MAN) and
Fuli Zhou +6 more
openaire +4 more sources
Resolution of a Metastable Racemic Compound of Anhydrous Phencyphos by Hydrate Formation
Crystals, 2021 The resolution of 2-hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphorinan 2-oxide (phencyphos) was achieved by dissolution of anhydrous racemic phencyphos, a racemic compound, accompanied by simultaneous secondary nucleation of the dissolved racemate on ...
Michel Leeman, Richard M. Kellogg
doaj +1 more source