Results 51 to 60 of about 189,493 (266)
Lógicas da antropotecnia: mensuração do homem e bio-sociologia (1860-1920)
Revista Brasileira de História, 2001 A antropometria é um método estatístico de análise do corpo humano criado por volta de 1850 para precisar o lugar do homem na natureza e definir os caracteres das raças humanas. Ela foi rapidamente utilizada para apreciar os fatores "biossociológicos" na
Claude Blanckaert
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Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
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Scientific opinion on the pest categorisation of Verticillium dahliae Kleb
EFSA Journal, 2014 The European Commission requested the EFSA Panel on Plant Health to perform a pest categorisation of Verticillium dahliae Kleb., the fungal pathogen responsible for many Verticillium wilt diseases. V.
EFSA Panel on Plant Health (PLH)
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FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
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Nuevo mundo - Mundos Nuevos, 2011 I have found that in the mid-nineteenth Century Mexico, the notions of race and sex became objects for science and favored the production of medical knowledge, and so it happened with obstetrics.
Laura Cházaro
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
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Siberian Journal of Life Sciences and AgricultureBackground. Researchers from France, Serbia, and Russia have reported the spread of Black Rot in winter rape crop. The cultivation of resistant varieties and hybrids is considered to be the most effective method of reducing the economic damage caused by ...
Anastasiia V. Vishnyakova +4 more
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