Results 61 to 70 of about 781,700 (285)

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Lógicas da antropotecnia: mensuração do homem e bio-sociologia (1860-1920)

open access: yesRevista Brasileira de História, 2001
A antropometria é um método estatístico de análise do corpo humano criado por volta de 1850 para precisar o lugar do homem na natureza e definir os caracteres das raças humanas. Ela foi rapidamente utilizada para apreciar os fatores "biossociológicos" na
Claude Blanckaert
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Scientific opinion on the pest categorisation of Verticillium dahliae Kleb

open access: yesEFSA Journal, 2014
The European Commission requested the EFSA Panel on Plant Health to perform a pest categorisation of Verticillium dahliae Kleb., the fungal pathogen responsible for many Verticillium wilt diseases. V.
EFSA Panel on Plant Health (PLH)
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Políticas del conocimiento: los silencios de los obstetras mexicanos sobre las razas y los sexos, fines del siglo XIX

open access: yesNuevo mundo - Mundos Nuevos, 2011
I have found that in the mid-nineteenth Century Mexico, the notions of race and sex became objects for science and favored the production of medical knowledge, and so it happened with obstetrics.
Laura Cházaro
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

WMUR / UNH Poll - GOP Candidates Lead in Both NH Congressional Races 10/11/2002 [PDF]

open access: yes, 2002
Republicans Jeb Bradley and Charlie Bass hold sizeable leads in races for New Hampshire’s 1st and 2nd Congressional Districts.
Survey Center, UNH
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

SmartTrack: Efficient Predictive Race Detection

open access: yes, 2020
Widely used data race detectors, including the state-of-the-art FastTrack algorithm, incur performance costs that are acceptable for regular in-house testing, but miss races detectable from the analyzed execution.
Biswas Swarnendu   +27 more
core   +1 more source

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