Results 151 to 160 of about 120,136 (313)

CRISPR‐Cas9 Genome‐Wide Screening in Paediatric Cancer: Functional Genomics for Target Discovery and the Improvement of Existing Therapies

Medicinal Research Reviews, EarlyView.
ABSTRACT CRISPR‐Cas9 genome‐wide screening has been instrumental towards identifying novel targets for drug discovery in cancer research. However, much of this research has centred specifically on adult cancers, with paediatric cancers being underserviced by current research and screening.
Steven He, Patrick Connerty, Antoine de Weck   +2 more
wiley   +1 more source

Non-coding RNA regulation of the radiation-induced DNA damage response and its translational relevance. [PDF]

Discov Oncol
Wilson C, Gaur A, Swaroop P, Vishwas V, Kumar S, Ghose S, Chopra A, Sharma DN, Bakhshi S, Sharawat SK.   +9 more
europepmc   +1 more source

Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives

Precision Medical Sciences, EarlyView.
Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley   +1 more source

Comparative analysis of molecular targeted radiosensitizers in 2D and 3D cancer cell line models. [PDF]

Acta Oncol
Ramirez Parra M, Dietrich A, Pfeifer M, Willers H, Krause M, Borgeaud N.   +5 more
europepmc   +1 more source

Robust Bioconjugated Antigens Induce Immune Responses Preventing Malaria Infection and its Transmission

Small, EarlyView.
Engineered malaria antigens enable in vivo bioconjugation to submicron biopolymer particles in E. coli. Two antigens are co‐tethered at high density and defined stoichiometry. The resulting thermostable particles elicit strong, durable antibody and T‐cell responses, conferring robust protection and blocking mosquito transmission.
Nivethika Sivakumaran, Yevel Flores‐Garcia, Chanel M. Naar, Shuxiong Chen, Mili Mehta, Fijs W. B. van Leeuwen, Abhai Tripathi, Rajagopal Murugan, Meta Roestenberg, Fidel Zavala, Bernd H. A. Rehm   +10 more
wiley   +1 more source

miR-181d coordinates homologous recombination and anti-tumor immune responses in glioblastoma. [PDF]

iScience
Singh G, Singh S, Mohapatra I, Hou J, Ni A, Barik D, Zheng H, Kim S, Sharma M, Lawler S, Vasudevan S, Kokkoli E, Sarangi S, Elinzano H, Wong ET, Martinez-Moreno M, Gokaslan Z, El-Deiry W, Chen CC.   +18 more
europepmc   +1 more source

Interfacial Nano‐Pitting and In Situ Sulfate‐Directed Growth of Na2.85V2(PO4)2.85(SO4)0.15 Nanodots on MWCNT for Ultrafast Sodium‐Ion Storage

Small, EarlyView.
Ultracentrifugation‐assisted phosphate–sulfate treatment induces self‐limiting nano‐pitting on carbon nanotube surfaces, creating confined sites for in situ growth of Na2.85V2(PO4)2.85(SO4)0.15 nanodots. This embedded nanodot–carbon interface ensures strong electronic coupling and short ion pathways, enabling capacitor‐like sodium storage with ...
Naohisa Okita, Akari Ukai, Akihumi Hatano, Keisuke Matsumura, Etsuro Iwama, Wako Naoi, Sreya Babu Nambiar, Pierre‐Louis Taberna, Patrick Rozier, Patrice Simon, Katsuhiko Naoi   +10 more
wiley   +1 more source

Enhancing radiosensitivity of boron neutron capture therapy for liver cancer with homologous recombination repair inhibitor. [PDF]

Jpn J Radiol
Lai ZY, Huang YH, Zhou TY, Lee CY, Shiao YM, Chen YW, Chou FI, Chen JK, Chuang YJ.   +8 more
europepmc   +1 more source

External Stimuli‐Activable Single‐Atom Nanozymes for Bioapplications

Small, EarlyView.
Stimuli‐activable single‐atom nanozymes (SANs) are reviewed from materials design to biomedical applications. We explain electronic‐structure tuning principles and synthesis strategies that maximize the responsiveness of metal active sites and supports to light, ultrasound, and magnetic fields.
Hyun Ko, Jungsue Choi, Hyeonjeong Noh, Sohyeon Seo, Heedong Kwon, Seungjune Lee, Hyoyoung Lee   +6 more
wiley   +1 more source

Comparing and combining xevinapant with ATR and PARP inhibition for the radiosensitization of HPV-negative HNSCC cells. [PDF]

Sci Rep
Roehrle J, Perugachi-Heinsohn A, Gatzemeier F, Christiansen S, Petersen C, Rothkamm K, Betz C, Kriegs M, Zech HB, Rieckmann T.   +9 more
europepmc   +1 more source