Results 71 to 80 of about 389,631 (317)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Computer modeling and experimental work on the astrobiological implications of the martian subsurface ionising radiation environment [PDF]

open access: yes, 2008
Any microbial life extant in the top meters of the martian subsurface is likely to be held dormant for long periods of time by the current permafrost conditions.
Dartnell, Lewis R, Dartnell, L.R.
core  

Microstructure and patterns of coherent radiation [PDF]

open access: yesInternational Astronomical Union Colloquium, 1996
Abstract We present data which indicates that micropulses from the bright millisecond pulsar PSR J0437–4715 are observed at equally-spaced preferred phases within the pulse window. We find the pattern similar to that expected if each micropulse is radiated from a source with a coherence scale of ~ 100 m.
J. G. Ables, D. McConnell
openaire   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Frequency Dependence of Pulsar Radiation Patterns

open access: yesThe Astrophysical Journal, 2002
24 pages, 8 figures.
Gil, J.   +3 more
openaire   +2 more sources

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

Radiation characteristics of corner reflector antennas.

open access: yes, 1998
PhDThis thesis presents a study of the radiation characteristics of corner reflector antennas. The influence of the design parameters on the radiation characteristics are assessed using an analytical method and the Finite Difference Time Domain (FDTD)
Sterr, U.
core  

A Compact Pattern Reconfigurable Antenna with 4 Different Radiation Modes

open access: yes, 2023
This letter presents the design, fabrication, and measurements of a pattern reconfigurable antenna operating at 3.3 GHz. A circular patch in the center and a ring around it are excited by two feeds to obtain broadside and conical radiation patterns ...
Gök, Čaǧlar, Alatan, Lale
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

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