Results 81 to 90 of about 349,910 (312)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Application of numerical methods to determine some parameters of radiation embrittlement of borosilicate glass

Қарағанды университетінің хабаршысы. Физика сериясы
In this paper, a numerical method for determining the parameters of radiation embrittlement in borosilicate glass is proposed. The method is based on analyzing the changes in the mechanical properties of the material atoms, the fluence Ф and the energy ...
Sh. M. Kazhykenov, G. U. Yerbolatova, A. K. Tussupbekova   +2 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Ionizing radiation can overcome resistance to TRAIL in TRAIL-resistant cancer cells [PDF]

, 2001
Although the majority of cancer cells are killed by TRAIL (tumor necrosis factor-related apoptosis-inducing ligand treatment), certain types show resistance to it.
이윤실
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Significant improvement of gamma radiation resistance in CeO2 doped phosphate glass by co-doping with Sb2O3

, 2017
We show that the gamma radiation resistances of new type of phosphate glass can be greatly improved by CeO2 and Sb2O3 co-doping. With the doping of CeO2, the radiation resistance (transmittance decrease ratio) is improved from 57.39% to 73.9% at 525 nm,
He, Quanlong, Quanlong He, Peng, Bo, Sun, Mengya, Min Lu, Lu, Min, Wang, Pengfei (pfwang@opt.ac.cn), Pengfei Wang, Wang, Pengfei, Mengya Sun, Bo Peng   +10 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Effects of the amount and size of hexagonal boron nitride on the radiation resistance of silicone rubber

Fushe yanjiu yu fushe gongyi xuebao
To enhance the radiation stability of silicone rubber (SR) and ensure its safe and reliable performance, hexagonal boron nitride (h-BN) was incorporated into SR as a functional filler.
WU Zhihao, LI Yifan, SHEN Hang, LIN Mingzhang   +3 more
doaj   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Experimental identification of the radiation resistance matrix

, 2019
The radiation resistance matrix allows for the calculation of structurally radiated sound power using a series of measured structural responses. Currently, estimating the radiation resistance matrix requires precise modelling of the structure which, for ...
Steve Daley, Cheer, Jordan, Joseph Milton, Daley, Stephen, Milton, Joseph, Jordan Cheer   +5 more
core   +2 more sources