Results 61 to 70 of about 286,073 (277)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Approximations for radiative cooling and heating in the solar chromosphere

, 2012
Context. The radiative energy balance in the solar chromosphere is dominated by strong spectral lines that are formed out of LTE. It is computationally prohibitive to solve the full equations of radiative transfer and statistical equilibrium in 3D time ...
Abbett, Allred, Allred, Anderson, Arnaud, Asplund, Bard, Burgess, Burgess, Carlsson, Carlsson, Carlsson, Carlsson, Cheng, Fossum, Fossum, Gudiksen, Hayek, Heinemann, J. Leenaarts, Jin, Johnson, Judge, Kašparová, Klein, Klein, Kupka, Leenaarts, Leenaarts, M. Carlsson, Meléndez, Menzel, Milkey, Piskunov, Rammacher, Shull, Sigut, Theodosiou, Tobiska, Vernazza, Vriens, Wahlstrom, Wedemeyer-Böhm   +42 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The early summertime Saharan heat low: sensitivity of the radiation budget and atmospheric heating to water vapour and dust aerosol [PDF]

Atmospheric Chemistry and Physics, 2018
The Saharan heat low (SHL) is a key component of the west African climate system and an important driver of the west African monsoon across a range of timescales of variability.
N. K. Alamirew, M. C. Todd, C. L. Ryder, J. H. Marsham, J. H. Marsham, Y. Wang   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Signatures of Supersymmetry in B Decays - A Theoretical Perspective [PDF]

, 2002
We discuss precision tests of the standard model in radiative and semileptonic rare B-decays and CP-violating asymmetries, and possible signatures of supersymmetry in these processes.
Ali, A.
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Radiative heating in the kinetic mode of AGN feedback

, 2017
AGN feedback is now widely believed to play a crucial role in the co-evolution between the central black hole and its host galaxy. Two feedback modes have been identified, namely the radiative and kinetic modes, which correspond to the luminous AGNs and ...
Ho, Luis C., Xie, Fu-Guo, Yuan, Feng
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Radiative processes involving fast mesons [PDF]

Proceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences, 1940
The general theory of the interaction of mesons with an electromagnetic field is developed, starting from Kemmer’s matrix formulation of the meson equations. The general theory is applied to the scattering of light by mesons, the emission of radiation by mesons during collisions and the production of pairs of mesons.
Booth, F., Wilson, A. H.
openaire   +2 more sources