Results 61 to 70 of about 28,077 (267)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Theoretical study of a highly fault-tolerant and scalable adaptive radiative cooler

Nanophotonics
Conventional static radiative coolers have an unadjustable cooling capacity, which often results in overcooling in low temperature environment. Therefore, there is a great need for an adaptive dynamic radiative cooler.
Li Bin, Hu Jiaqi, Chen Changhao, Hu Hengren, Zhong Yetao, Song Ruichen, Cao Boyu, Peng Yunqi, Xia Xusheng, Chen Kai, Xia Zhilin   +10 more
doaj   +1 more source

Tungsten Ions in Plasmas: Statistical Theory of Radiative-Collisional Processes

Atoms, 2015
The statistical model for calculations of the collisional-radiative processes in plasmas with tungsten impurity was developed. The electron structure of tungsten multielectron ions is considered in terms of both the Thomas-Fermi model and the Brandt ...
Alexander V. Demura, Mikhail B. Kadomtsev, Valery S. Lisitsa, Vladimir A. Shurygin   +3 more
doaj   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Dynamics of femtosecond lasers and induced plasma in non-Kerr nonlinear transparent materials: Competing effects of electron–hole radiative recombinations and single-electron diffusions

AIP Advances
Modern laser micromachining utilizes ultrashort optical fields, such as femtosecond lasers, to perform high-precision processings on solid materials, including cutting, drilling, ablation, polishing, and scripturing.
I. Ngek Ndifon, Alain M. Dikandé
doaj   +1 more source

Interstellar processes: Ortho/para conversion, radiative association, and dissociative recombination

EPJ Web of Conferences, 2015
The study of the ortho-to-para ratio of assorted gas-phase interstellar molecules such as H2, H2O, NH3, and H2O+ has gained interest in recent years, based partially on new spectral observations of light hydrides by the Herschel Space Observatory ...
Herbst Eric
doaj   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Ionized Envelopes Around Protoplanets and the Role of Radiative Feedback in Gas Accretion

The Astrophysical Journal
Planetary growth within protoplanetary disks involves the accreting of material from their surroundings, yet the underlying mechanisms and physical conditions of the accreting gas remain debated.
Matías Montesinos, Juan Garrido-Deutelmoser, Jorge Cuadra, Mario Sucerquia, Nicolás Cuello, Matthias R. Schreiber, María Paula Ronco, Octavio M. Guilera   +7 more
doaj   +1 more source