Results 31 to 40 of about 31,927 (257)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
crash: a radiative transfer scheme [PDF]
Monthly Notices of the Royal Astronomical Society, 2003 We present a largely improved version of CRASH, a 3-D radiative transfer code that treats the effects of ionizing radiation propagating through a given inhomogeneous H/He cosmological density field, on the physical conditions of the gas. The code, based on a Monte Carlo technique, self-consistently calculates the time evolution of gas temperature and ...
MASELLI A., FERRARA, ANDREA, CIARDI B.
openaire +5 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Journal of Thermal Science and Technology, 2011 Thermal radiation in a turbulent natural convection plays an important role in a wide area of engineering and nature. The purposes of this study are to investigate the effects of turbulent fluctuation on radiative heat transfer, and to evaluate radiative
Atsushi SAKURAI +3 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Resonance Energy Transfer Molecular Imaging Application in Biomedicine
Journal of Isotopes, 2016 Resonance energy transfer molecular imaging (RETI) can markedly improve signal intensity and tissue penetrating capacity of optical imaging, and have huge potential application in the deep-tissue optical imaging in vivo.
NIE Da-hong1,2;TANG Gang-hua1,3
doaj +1 more source
Radiative transfer in silylidene molecule [PDF]
Serbian Astronomical Journal, 2014 In order to search for silylidene (H2CSi) in the interstellar medium, Izuha et al. (1996) recorded microwave spectrum of H2CSi in laboratory and made an unsuccessful attempt of its identification in IRC +10216, Ori KL, Sgr B2, through its 717-616 ...
Sharma M. +3 more
doaj +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source