Results 61 to 70 of about 277,108 (344)
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Link between the laws of geometrical optics and the radiative transfer equation in media with a spatially varying refractive index [PDF]
, 2007 We proposed in a previous paper [Opt. Commun. 228, 33 (2003)] a modified radiative transfer equation to describe radiative transfer in a medium with a spatially varying refractive index.
Bal +17 more
core +3 more sources
Radiative transfer in silylidene molecule [PDF]
Serbian Astronomical Journal, 2014 In order to search for silylidene (H2CSi) in the interstellar medium, Izuha et al. (1996) recorded microwave spectrum of H2CSi in laboratory and made an unsuccessful attempt of its identification in IRC +10216, Ori KL, Sgr B2, through its 717-616 ...
Sharma M. +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova +26 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
START: Smoothed particle hydrodynamics with tree-based accelerated radiative transfer [PDF]
, 2010 We present a novel radiation hydrodynamics code, START, which is a smoothed particle hydrodynamics (SPH) scheme coupled with accelerated radiative transfer.
Ahn +34 more
core +3 more sources
Identifying prognostic targets in metastatic prostate cancer beyond AR
FEBS Open Bio, EarlyView.Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng +13 more
wiley +1 more source
A Unifying Polarization Formalism for Electric and Magnetic Multipole Interactions
The Astrophysical JournalWe extend the spherical tensorial formalism for polarization to the treatment of electric and magnetic multipole transitions of any order. We rely on the spherical-wave expansion to derive the tensor form of the operator describing the interaction of the
R. Casini +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao +7 more
wiley +1 more source