Results 61 to 70 of about 4,184,658 (417)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Toward a Psychological Framework of Radical Healing in Communities of Color
Counseling Psychologist, 2020 Advancing beyond individual-level approaches to coping with racial trauma, we introduce a new psychological framework of radical healing for People of Color and Indigenous individuals (POCI) in the United States.
Bryana H. French +6 more
semanticscholar +1 more source
Mitochondrially targeted compounds and their impact on cellular bioenergetics
Redox Biology, 2013 Mitochondria are recognized as critical sites of localized injury in a number of chronic pathologies which has led to the development of organelle directed therapeutics.
Colin Reily +5 more
doaj +1 more source
Diphthamide synthesis is linked to the eEF2‐client chaperone machinery
FEBS Letters, EarlyView.The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr +4 more
wiley +1 more source
Journal of Innovation Management, 2019 What drives growth becomes cancerous when it goes beyond limits. Contrary to this common sense, today, consumerism drives our economies and feeds our appetite for ever-growing wants.
Krishnaswamy Sankaran
doaj +1 more source
Fragmentation of a dioxolanyl radical via nonstatistical reaction dynamics: characterization of the vinyloxy radical by ns time-resolved laser flash photolysis [PDF]
, 2018 The photochemistry of two Barton esters, one derived from a dioxolane carboxylic acid and the other from pivalic acid, was investigated by product analysis and nanosecond laser flash photolysis (LFP).
Bucher, Götz +3 more
core +1 more source
Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions
FEBS Letters, EarlyView.This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten +10 more
wiley +1 more source
Ecoso exchange no. 8 : incorporating Irregular no. 58 [PDF]
, 1974 In this issue: 1. Big National Event Coming: Radical Ecology Conference (R.E.C.) - Challenge to Readers. 2. Two posers for the mid 1970's: Can the small "l" liberals go radical? How radical are the A.L.P "lefties"? 3. Introduction to two enclosures:
core
FEBS Letters, EarlyView.Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung +6 more
wiley +1 more source
Survival after Minimally Invasive Radical Hysterectomy for Early‐Stage Cervical Cancer
New England Journal of Medicine, 2018 BACKGROUND Minimally invasive surgery was adopted as an alternative to laparotomy (open surgery) for radical hysterectomy in patients with early‐stage cervical cancer before high‐quality evidence regarding its effect on survival was available.
A. Melamed +13 more
semanticscholar +1 more source