Results 151 to 160 of about 495,743 (373)

A Para‐Selective Kolbe–Schmitt Reaction

open access: yesAngewandte Chemie, EarlyView.
Discovered over 150 years ago, the Kolbe–Schmitt carboxylation has established itself as one of the most well‐known chemical reactions. However, the process often requires extreme pressures and high temperatures. Here, we present a unique para‐selective Kolbe–Schmitt‐type carboxylation that proceeds at relatively low temperatures and uses near ...
Xia Liu   +2 more
wiley   +2 more sources

Analysis of spatial distribution and inventory of radioactivity within the uranium mill tailings impoundment

open access: yesЯдерна фізика та енергетика, 2015
Results are presented of the characterization of radioactivity inventory of Zapadnoe uranium mill tailings impoundment situated at Pridneprovsky Chemical Plant (PChP; Dneprodzerzhinsk, Ukraine).
D. O. Bugai   +4 more
doaj  

Genomics Review of Selective RET Inhibitors Sensitivity in Thyroid Cancer Clinical Trials

open access: yesAmerican Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT RET gene is a driver of thyroid cancer (TC) tumorigenesis. The incidence of TC has increased worldwide in the last few decades, both in medullary and follicular‐derived subtypes. Several drugs, including multikinase and selective inhibitors, have been explored.
Sara Gil‐Bernabé   +5 more
wiley   +1 more source

18F‐Radiopharmaceutical Diversification Enabled by Deaminative Cross‐Electrophile Couplings

open access: yesAngewandte Chemie, EarlyView.
A general Ni‐mediated (C)sp2–(C)sp3 cross‐coupling expedites access to 18F‐radiopharmaceuticals, essential for positron emission tomography imaging and drug discovery. This late‐stage diversification approach was implemented across three user‐friendly automated protocols affording 18F‐radiotracers in sufficient quantities for imaging.
Isabella F. Ogilvy   +13 more
wiley   +2 more sources

Repurposing With Purpose: Treatment of Bachmann–Bupp Syndrome With Eflornithine and Implications for Other Polyaminopathies

open access: yesAmerican Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Rare diseases impact approximately 1 in 10 people worldwide, and yet, less than 5% of all rare diseases currently have an approved treatment option available. This is due to many challenges unique to rare diseases, including small, diverse patient populations, the cost of drug development that is not proportionate to the number of patients who
Caleb P. Bupp   +7 more
wiley   +1 more source

Radiation emergency medical countermeasures: Current formulary, identified gaps, and future approaches

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Current radiation medical countermeasures primarily focus on hematopoietic acute radiation syndrome (H‐ARS) using agents like granulocyte colony‐stimulating factor (G‐CSF), granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), and romiplostim, alongside treatments for internal contamination (Prussian blue, diethylenetriamine pentaacetate [DTPA ...
Wen‐Bing Ma   +12 more
wiley   +1 more source

Logarithmic and Strong Coupling Models in Weyl‐Type f(Q,T)$f(Q,T)$ Gravity

open access: yesAnnalen der Physik, EarlyView.
This work explores Weyl‐type f(Q,T) gravity using recent observational datasets — CC, Pantheon+, Union 3.0, and DESI DR2. Through MCMC analysis of logarithmic and strong coupling models, the study reveals a transition from deceleration to acceleration, quintessence‐to‐phantom dynamics, and late‐time consistency with LCDM, offering a geometry‐driven ...
Rahul Bhagat, S. K. Tripathy, B. Mishra
wiley   +1 more source

On the drivers of ice nucleating particle diurnal variability in Eastern Mediterranean clouds

open access: yesnpj Climate and Atmospheric Science
We report the drivers of spatiotemporal variability of ice nucleating particles (INPs) for mixed-phase orographic clouds (~−25 °C) in the Eastern Mediterranean.
Kunfeng Gao   +11 more
doaj   +1 more source

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