Results 31 to 40 of about 27,411 (234)
Reaction Chemistry & Engineering, 2022 The automation of positron emission tomography (PET) radiochemistry using cassette-based automated radiosynthesis platforms is an essential component of clinical translation for the vast majority of 18F-based radiopharmaceuticals.
Chris P. Barnes +4 more
semanticscholar +1 more source
First GPR119 PET Imaging Ligand: Synthesis, Radiochemistry, and Preliminary Evaluations.
Journal of Medicinal Chemistry, 2023 G-protein-coupled receptor 119 (GPR119) has emerged as a promising target for treating type 2 diabetes mellitus. Activating GPR119 improves glucose homeostasis, while suppressing appetite and weight gain.
Avinash H Bansode +12 more
semanticscholar +1 more source
Weapons Radiochemistry: Trinity and Beyond [PDF]
Nuclear Technology, 2021 On July 16, 1945, the Trinity nuclear test exploded in the desert near Alamogordo, New Mexico. A variety of new diagnostic experiments were fielded in an effort to understand the detailed performance of the nuclear device.
S. Hanson, W. Oldham
semanticscholar +1 more source
Fully Automated GMP-Compliant Synthesis of [18F]FE-PE2I
Pharmaceuticals, 2021 In the struggle to understand and accurately diagnose Parkinson′s disease, radiopharmaceuticals and medical imaging techniques have played a major role. By being able to image and quantify the dopamine transporter density, noninvasive diagnostic imaging ...
Klas Bratteby +8 more
doaj +1 more source
Silicon-[18F]Fluorine Radiochemistry: Basics, Applications and Challenges
Applied Sciences, 2012 Silicon-[18F]fluorine (Si-18F) radiochemistry has recently emerged alongside other unconventional approaches such as aluminum-18F and boron-18F based labeling strategies, reshaping the landscape of modern 18F-radiochemistry. All these novel methodologies
Carmen Wängler +5 more
doaj +1 more source
Molecules, 2022 [18F]sodium fluoride ([18F]NaF) is recognised to be superior to [99mTc]-methyl diphosphate ([99mTc]Tc-MDP) and 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) in bone imaging. However, there is concern that [18F]NaF uptake is not cancer-specific, leading to a
Hishar Hassan +10 more
doaj +1 more source
Pharmaceuticals, 2023 The Pd–Xantphos-mediated 11C-carbonylation protocol (also known as the “Xantphos- method”), due to its simplistic and convenient nature, has facilitated researchers in meeting a longstanding need for preparing 11C-carbonyl-labeled radiopharmaceuticals at
Kenneth Dahl +3 more
doaj +1 more source
Microliter-scale reaction arrays for economical high-throughput experimentation in radiochemistry
Scientific Reports, 2022 The increasing number of positron-emission tomography (PET) tracers being developed to aid drug development and create new diagnostics has led to an increased need for radiosynthesis development and optimization.
Alejandra Rios +5 more
semanticscholar +1 more source
First measurement of the 10B(α,n)13N reaction in an inertial confinement fusion implosion at the National Ignition Facility: Initial steps toward the development of a radiochemistry mix diagnostic [PDF]
Physics of Plasmas, 2021 We report the first measurement of the [Formula: see text] reaction in a polar-direct-drive exploding pusher (PDXP) at the National Ignition Facility (NIF).
D. Lonardoni +14 more
semanticscholar +1 more source
Molecules, 2021 Pretargeted nuclear imaging for the diagnosis of various cancers is an emerging and fast developing field. The tetrazine ligation is currently considered the most promising reaction in this respect. Monoclonal antibodies are often the preferred choice as
Christian B. M. Poulie +6 more
doaj +1 more source