Results 31 to 40 of about 12,648 (203)

The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules

EJNMMI Radiopharmacy and Chemistry, 2021
The aluminium-[ 18 F]fluoride ([ 18 F]AlF) radiolabelling method combines the favourable decay characteristics of fluorine-18 with the convenience and familiarity of metal-based radiochemistry and has been used to parallel gallium-68 radiopharmaceutical ...
S. Archibald, L. Allott
semanticscholar   +1 more source

Automated Synthesis of 18F-BCPP-EF {2-tert-Butyl-4-Chloro-5-{6-[2-(2[18F]fluoroethoxy)-Ethoxy]-Pyridin-3-ylmethoxy}-2H-Pyridazin-3-One for Imaging of Mitochondrial Complex 1 in Parkinson’s Disease

Frontiers in Chemistry, 2022
Graphical ...
Tanpreet Kaur, Allen F. Brooks, Katherine M. Liddell, Bradford D. Henderson, Brian G. Hockley, Nicolaas I. Bohnen, Nicolaas I. Bohnen, Nicolaas I. Bohnen, Nicolaas I. Bohnen, Roger L. Albin, Roger L. Albin, Roger L. Albin, Peter J. H. Scott   +12 more
doaj   +1 more source

Targeted Alpha Therapy: Progress in Radionuclide Production, Radiochemistry, and Applications

Pharmaceutics, 2020
This review outlines the accomplishments and potential developments of targeted alpha (α) particle therapy (TAT). It discusses the therapeutic advantages of the short and highly ionizing path of α-particle emissions; the ability of TAT to complement and ...
Bryce J B Nelson, J. Andersson, F. Wuest
semanticscholar   +1 more source

A practical guide to automating fluorine-18 PET radiochemistry using commercially available cassette-based platforms

Reaction Chemistry & Engineering, 2022
The automation of positron emission tomography (PET) radiochemistry using cassette-based automated radiosynthesis platforms is an essential component of clinical translation for the vast majority of 18F-based radiopharmaceuticals.
Chris P. Barnes, M. Nair, E. Aboagye, Steve J Archibald, L. Allott   +4 more
semanticscholar   +1 more source

The Rise of Synaptic Density PET Imaging

Molecules, 2020
Many neurological disorders are related to synaptic loss or pathologies. Before the boom of positrons emission tomography (PET) imaging of synapses, synaptic quantification could only be achieved in vitro on brain samples after autopsy or surgical ...
Guillaume Becker, Sylvestre Dammicco, Mohamed Ali Bahri, Eric Salmon   +3 more
doaj   +1 more source

Novel Receptor Tyrosine Kinase Pathway Inhibitors for Targeted Radionuclide Therapy of Glioblastoma

Pharmaceuticals, 2021
Glioblastoma (GB) remains the most fatal brain tumor characterized by a high infiltration rate and treatment resistance. Overexpression and/or mutation of receptor tyrosine kinases is common in GB, which subsequently leads to the activation of many ...
Julie Bolcaen, Shankari Nair, Cathryn H. S. Driver, Tebatso M. G. Boshomane, Thomas Ebenhan, Charlot Vandevoorde   +5 more
doaj   +1 more source

Microliter-scale reaction arrays for economical high-throughput experimentation in radiochemistry

Scientific Reports, 2022
The increasing number of positron-emission tomography (PET) tracers being developed to aid drug development and create new diagnostics has led to an increased need for radiosynthesis development and optimization.
Alejandra Rios, Travis Holloway, Philip H. Chao, C. De Caro, Chelsea C. Okoro, R. M. van Dam   +5 more
semanticscholar   +1 more source

Development of Customized [18F]Fluoride Elution Techniques for the Enhancement of Copper-Mediated Late-Stage Radiofluorination

Scientific Reports, 2017
In a relatively short period of time, transition metal-mediated radiofluorination reactions have changed the PET radiochemistry landscape. These reactions have enabled the radiofluorination of a wide range of substrates, facilitating access to ...
Andrew V. Mossine, Allen F. Brooks, Naoko Ichiishi, Katarina J. Makaravage, Melanie S. Sanford, Peter J. H. Scott   +5 more
doaj   +1 more source

Synthesis of Novel, Dual-Targeting ⁶⁸Ga-NODAGA-LacN-E[c(RGDfK)]₂ Glycopeptide as a PET Imaging Agent for Cancer Diagnosis

Pharmaceutics, 2021
Radiolabeled peptides possessing an Arg-Gly-Asp (RGD) motif are widely used radiopharmaceuticals for PET imaging of tumor angiogenesis due to their high affinity and selectivity to αvβ3 integrin.
Barbara Gyuricza, Judit P. Szabó, Viktória Arató, Dániel Szücs, Adrienn Vágner, Dezső Szikra, Anikó Fekete   +6 more
doaj   +1 more source

The Metamorphosis of Radionuclide Production and Development at Paul Scherrer Institute

CHIMIA, 2020
Radionuclide production and development has a long history at the Paul Scherrer Institute (PSI) and dates back to the founding times of its forerunner institutions: the Federal Institute for Reactor Research and the Swiss Institute for Nuclear Research ...
Pascal V. Grundler, Robert Eichler, Zeynep Talip, P. August Schubiger, Roger Schibli, Nicholas P. van der Meulen   +5 more
doaj   +1 more source