Results 91 to 100 of about 74,605 (231)
Clinical Pharmacology in Drug Development, Volume 14, Issue 12, Page 934-950, December 2025.Abstract This 2‐part, randomized, placebo‐controlled, double‐blind, Phase 1 study analyzed the pharmacokinetics, safety, and biomarker profile of fezolinetant in healthy Japanese individuals. Part 1: male participants received single doses of placebo or fezolinetant 15 or 60 mg.
Akira Koibuchi +8 more
wiley +1 more source
Food Science &Nutrition, Volume 13, Issue 12, December 2025.Quinoa alleviates liver injury, glucose/lipid metabolic disorders, and insulin resistance in high‐fat diet‐induced NAFLD mice. Mechanistically, it acts by inhibiting the Ras‐PLD signaling pathway, activating autophagy, and regulating key related protein/gene expressions, as validated via network pharmacology, transcriptomics, and in vivo experiments ...
Yuelin Zhang +6 more
wiley +1 more source
Food Science &Nutrition, Volume 13, Issue 12, December 2025.In this cross‐sectional study of 250 overweight and obese Iranian women, food insecurity was significantly associated with higher odds of the hypertriglyceridemic waist (HTGW) phenotype. Women experiencing food insecurity had more than twice the likelihood of presenting the HTGW phenotype compared with food‐secure counterparts (adjusted OR = 2.13, 95 ...
Paria Jadidi +7 more
wiley +1 more source
A SOLID-PHASE RADIOIMMUNOASSAY FOR PROGESTERONE IN BOVINE PLASMA [PDF]
, 1980 G. de Boer, R. J. Etches, J.S. Walton
openalex +1 more source
Saliva as a TDM Matrix and Its Application in the Model‐Informed Precision Dosing
The Journal of Clinical Pharmacology, Volume 65, Issue 12, Page 1650-1660, December 2025.Abstract This study reviews the main points of saliva as a therapeutic drug monitoring (TDM) matrix, its advantages and limitations, the methods of saliva sample collection and testing, the types of drugs in saliva TDM, and the methods of establishing saliva population pharmacokinetic (Pop PK) models, as well as summarizes the experiences and ...
Baohua Xu +9 more
wiley +1 more source
A modified radioimmunoassay for antibodies against Brucella abortus [PDF]
, 1982 R.J. Chappel +3 more
openalex +1 more source
Hormones reflect the impacts of reproductive rest on subsequent pregnancy in a marine predator
Functional Ecology, Volume 39, Issue 12, Page 3417-3433, December 2025.Read the free Plain Language Summary for this article on the Journal blog. Abstract After reaching sexual maturity, iteroparous female vertebrates may intermittently skip producing offspring, effectively taking a year of reproductive rest. This may confer benefits to lifetime fitness by enhancing future reproductive success.
Amy L. Kirkham +7 more
wiley +1 more source
Development of a radioimmunoassay for the fibrinogen-derived peptide B beta 1-42 [PDF]
, 1986 JI Weitz +4 more
openalex +1 more source
Elevated cortisol concentration in preterm sheep fetuses impacts heart development
Experimental Physiology, Volume 110, Issue 12, Page 1928-1947, December 1, 2025.Abstract The prepartum rise in cortisol promotes cardiac development and maturation. Here, we investigated the impact of elevated circulating cortisol during mid‐late gestation on cardiac growth and metabolism in fetal sheep. Saline or cortisol (2–3 mg in 4.4 mL/24 h) was infused into the fetal jugular vein from 109 to 116 days gestation (dG, term ...
Reza Amanollahi +9 more
wiley +1 more source
Experimental Physiology, Volume 110, Issue 12, Page 1795-1801, December 1, 2025.Abstract Blood‐based measures are considered the gold standard for evaluating steroid hormone concentrations, particularly for confirmation of hormone profiles in female‐specific research. However, saliva sampling offers several advantages: it can be collected independently by participants, is less invasive and might be a more time‐ and cost‐effective ...
Natalie J. Hardaker +4 more
wiley +1 more source