Results 91 to 100 of about 12,381 (205)

Current Status of Research on Losartan in Tumour Therapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Losartan, a widely prescribed antihypertensive agent, has attracted growing interest as a potential adjuvant in cancer therapy due to its affordability, established safety profile and pleiotropic effects. Emerging preclinical evidence demonstrates that losartan can effectively modulate the tumour microenvironment (TME) by inhibiting ...
Han Wang, Shuang Yuan, Hongjing Wang
wiley   +1 more source

Radioimmunotherapy and colorectal cancer

British Journal of Surgery, 2005
AbstractBackgroundDespite the success of radioimmunotherapy (RIT) using radiolabelled monoclonal antibodies (Mabs) directed against tumour-associated antigens in the treatment of non-Hodgkin's lymphoma, therapeutic success in solid tumours has been modest. In the past decade, a dozen Mabs have been investigated clinically for their potential usefulness
Koppe, M.J., Bleichrodt, R.P., Oyen, W.J.G., Boerman, O.C.   +3 more
openaire   +4 more sources

In Vivo Radionuclide Generators for Diagnostics and Therapy [PDF]

, 2016
In vivo radionuclide generators make complex combinations of physical and chemical properties available for medical diagnostics and therapy. Perhaps the best-known in vivo generator is 212Pb/212Bi, which takes advantage of the extended half-life of 212Pb
Edem, Patricia E., Fonslet, Jesper, Herth, Matthias, Kjær, Andreas, Severin, Gregory   +4 more
core   +3 more sources

Radiation‐Induced Biological Effects: Molecular and Cellular Mechanism, and Applications to Radiation/Nuclear Emergency and Cancer Therapy

MedComm, Volume 6, Issue 12, December 2025.
Radiation‐induced biological effects are an extremely complex and extensive mechanism that involves multiple aspects of physiological activities in organisms. In the medical field, utilizing the damaging effects of radiation to treat tumors is a commonly employed therapeutic approach.
Zhihe Hu, Yan Chen, Shengyi Yang, Shihai Diao, Le Ma, Chunmeng Shi   +5 more
wiley   +1 more source

Comparative Radioimmunotherapy of Experimental Melanoma with Novel Humanized Antibody to Melanin Labeled with 213Bismuth and 177Lutetium

Pharmaceutics, 2019
Melanoma is a cancer with increasing incidence and there is a need for alternatives to immunotherapy within effective approaches to treatment of metastatic melanoma.
Kevin J. H. Allen, Rubin Jiao, Mackenzie E. Malo, Connor Frank, Darrell R. Fisher, David Rickles, Ekaterina Dadachova   +6 more
doaj   +1 more source

Bone marrow dosimetry in peptide receptor radionuclide therapy with [177Lu-DOTA0,Tyr3]octreotate [PDF]

, 2009
Adequate dosimetry is mandatory for effective and safe peptide receptor radionuclide therapy (PRRT). Besides the kidneys, the bone marrow is a potentially dose-limiting organ.
Flavio Forrer, Eric P. Krenning, Peter P. Kooij, Bert F. Bernard, Mark Konijnenberg, Willem H. Bakker, Jaap J. M. Teunissen, Marion de Jong, Kirsten van Lom, Wouter W. de Herder, Dik J. Kwekkeboom   +10 more
core   +1 more source

Targeting Metabolic Reprogramming in Tumor: From Mechanisms to Precision Immunotherapies

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Cancer metabolic reprogramming is a key hallmark of tumorigenesis and antitumor immunity. It boosts tumor progression by enhancing cancer cell fitness in hostile microenvironments and facilitates immune evasion by evading natural and therapy‐driven antitumor immune responses.
Tong Zhang, Ping Gao, Linchong Sun
wiley   +1 more source

Study of the impact of tissue density heterogeneities on 3-dimensional abdominal dosimetry: comparison between dose kernel convolution and direct monte carlo methods. [PDF]

, 2012
Dose kernel convolution (DK) methods have been proposed to speed up absorbed dose calculations in molecular radionuclide therapy. Our aim was to evaluate the impact of tissue density heterogeneities (TDH) on dosimetry when using a DK method and to ...
Baechler, S., Boubaker, A., Dieudonné, A., Gardin, I., Hobbs, R.F., Le Guludec, D., Lebtahi, R., Maurel, F., Sgouros, G., Wahl, R.L.   +9 more
core   +2 more sources

Thiacalix[4]arene derivatives bearing imidazole units : a ditopic hard/soft receptor for Na⁺ and K⁺/Ag⁺ with an allosteric effect and a reusable extractant for dichromate anions [PDF]

, 2016
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Two novel receptors 5,11,17,23-tetra-tert-butyl-25,27-bis[(ethoxycarbonyl)methoxy]-26,28-bis-[1-methyl-(imidazole)meth-oxy] -2,8,14,20-tetra-thiacalix[4]arene (L1) and 5,11,17,23-tetra-tert-butyl-25,27 ...
Akgemci, Beer, Edwards, Endoh, Goyal, Kovbasyuk, Kremer, Krishna, Kumar, Lamouchi, Li, Liao, Lifschitz, Linton, Livitzki, Melaiye, Molina, Morohashi, Nabeshima, Nabeshima, Nabeshima, Nabeshima, Ni, Ni, Raji, Saiki, Singha, Stryer, Svanholm, Tabakci, Tabakci, Takeuchi, Tomiyasu, Tomiyasu, Yamato, Yamato, Yilmaz, Yilmaz, Zhao, Zhao, Zhao   +40 more
core   +5 more sources

Combination of 131I-anti-endoglin monoclonal antibody and 5-fluorouracil may be a promising combined-modality radioimmunotherapy strategy for the treatment of hepatocellular carcinoma

Biotechnology & Biotechnological Equipment, 2018
The present study aimed to investigate the therapeutic efficacy of combined radioimmunoconjugate 131I endoglin (ENG) and 5-fluorouracil (5-FU) in mouse model with hepatocellular carcinoma (HCC).
Chongling Duan, Yanxiang Li, Weifei Yang, Chao Zhang   +3 more
doaj   +1 more source