Results 61 to 70 of about 13,452 (195)
Cancer Management and Research, 2009 Christos EmmanouilidesDepartment of Medical Oncology, Interbalkan Hospital, Thessaloniki, GreeceAbstract: Several studies have indicated that radioimmunotherapy is an effective and clinically relevant complementary therapeutic approach for patients with ...
Christos Emmanouilides
doaj
Toward the Optimization of Click-Mediated Pretargeted Radioimmunotherapy.
Molecular Pharmaceutics, 2019 Pretargeted radioimmunotherapy (PRIT) based on the inverse electron demand Diels-Alder reaction has shown promise in murine models of disease, yet the radiation dosimetry of this approach must be optimized to make it a viable clinical option. To this end,
Rosemery Membreno +6 more
semanticscholar +1 more source
Pharmaceuticals, 2015 Faced with the novelty of a 212Pb-labeled monoclonal antibody (mAb) for clinical translation, concerns were expressed by the Food and Drug Administration (FDA) regarding 212Pb prematurely released from the mAb-chelate conjugate.
Diane E. Milenic +7 more
doaj +1 more source
Click-Mediated Pretargeted Radioimmunotherapy of Colorectal Carcinoma.
Molecular Pharmaceutics, 2018 Pretargeted radioimmunotherapy (PRIT) based on the inverse electron demand Diels-Alder (IEDDA) reaction between tetrazine (Tz) and trans-cyclooctene (TCO) represents a promising strategy for leveraging the affinity and specificity of antibodies without ...
Rosemery Membreno +4 more
semanticscholar +1 more source
Biotechnology & Biotechnological Equipment, 2018 The present study aimed to investigate the therapeutic efficacy of combined radioimmunoconjugate 131I endoglin (ENG) and 5-fluorouracil (5-FU) in mouse model with hepatocellular carcinoma (HCC).
Chongling Duan +3 more
doaj +1 more source
CNS Oncology, 2019 Management of high-grade gliomas (HGGs) remains a complex challenge with an overall poor prognosis despite aggressive multimodal treatment. New translational research has focused on maximizing tumor cell eradication through improved tumor cell targeting ...
Joshua Loya +4 more
doaj +1 more source
Radioimmunotherapy as a Novel Approach in HIV, Bacterial, and Fungal Infectious Diseases.
Cancer Biotherapy and Radiopharmaceuticals, 2018 In the past several decades, many antimicrobial agents have been used in treating different fungal, bacterial, and viral infections. However, these agents have faced challenges such as pronounced side-effect profiles and pathogen resistance. In addition,
M. Helal, E. Dadachova
semanticscholar +1 more source
Whither Radioimmunotherapy: To Be or Not To Be?
Cancer Research, 2017 Therapy of cancer with radiolabeled monoclonal antibodies has produced impressive results in preclinical experiments and in clinical trials conducted in radiosensitive malignancies, particularly B-cell lymphomas.
D. Green, O. Press
semanticscholar +1 more source
Monoclonal Antibodies in Cancer Therapy
Cancer Biology & Medicine, 2011 Monoclonal antibodies (MAbs) are a relatively newinnovation in cancer treatment. At present, some monoclonalantibodies have increased the efficacy of the treatment of certaintumors with acceptable safety profiles. When monoclonal antibodiesenter the body
Yu-Ting GUO, Qin-Yu HOU, Nan WANG
doaj +1 more source
Can occult metastases be Treated by radioimmunotherapy? [PDF]
, 1997 Robert M. Dunn +4 more
openalex +1 more source