Results 61 to 70 of about 15,914 (251)

Eleven-year experience with the avidin-biotin pretargeting system in glioblastoma: Toxicity, efficacy and survival [PDF]

, 2012
Background: The 3-step avidin-biotin pretargeting approach is applied in patients with recurrent glioblastoma (GBM), using biotinylated anti-tenascin monoclonal antibody as the first step of pretargeting followed by avidin and 90Ybiotin.
Baio, Silvia M., Bartolomei, Mirco, Bodei, Lisa, Broggi, Giovanni, Chinol, Marco, Cremonesi, Marta, De Cicco, Concetta, Grana, Chiara M., Pacifici, Monica, Paganelli, Giovanni, Rocca, Paola A., Severi, Stefano, Tiberini, Simone   +12 more
core   +2 more sources

Advancements in Targeted Radiopharmaceuticals: Innovations in Diagnosis and Therapy for Enhanced Cancer Management

ChemBioChem, Volume 27, Issue 1, January 2026.
Radiopharmaceuticals enable precise cancer diagnosis and targeted therapy by combining radioactive isotopes with carrier molecules. This review summarizes advances from 2014 to 2025, emphasizing probe design, click chemistry, novel targets, and nanodelivery systems.
Mohd Sayeed Shaikh, Rupesh R. Kurhade, Abrar A. M. Siddiqui, Shaikh Shahbaz A. Majeed, Thomas J. Webster, Mohammad Intakhab Alam, Abdul Wasy Zia, Md. Faiyazuddin   +7 more
wiley   +1 more source

Early Diagnosis of Alzheimer's Disease by NIRF Spectroscopy\ud and Nuclear Medicine\ud [PDF]

, 2011
Novel approaches to Early Diagnosis of Alzheimer's Disease by NIRF Spectroscopy and Nuclear Medicine are presented and related cognitive, as well as molecular and cellular, models are critically evaluated ...
Baianu, Prof.Dr. I.C.
core  

Newly Identified Transcriptomic Biomarkers and Gene Signature of Pathological Complete Response to Induction Chemoimmunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma

MedComm, Volume 7, Issue 1, January 2026.
Scheme and pathological characteristics of the CheckRad‐CD8 trial cohort used for the transcriptome analyses. (A) Flow diagram depicting the patient cohort and study scheme as the basis for whole transcriptome profiling of samples from locally advanced HNSCC patients treated with induction chemoimmunotherapy (iCIT).
Jian‐Guo Zhou, Markus Eckstein, Haitao Wang, Tianjun Lan, Benjamin Frey, Xin Li, Xiaofan Lu, Gunther Klautke, Thomas Illmer, Maximilian Fleischmann, Simon Laban, Matthias G. Hautmann, Bálint Tamaskovics, Thomas B. Brunner, Arndt Hartmann, Rainer Fietkau, Hu Ma, Antoniu‐Oreste Gostian, Heinrich Iro, Markus Hecht, Udo S. Gaipl   +20 more
wiley   +1 more source

Antibody conjugates in neuroblastoma: a step forward in precision medicine

Frontiers in Oncology
Neuroblastoma (NB) is a pediatric cancer that often manifests in a high-risk form and is characterized by frequent relapses and resistance to conventional therapies.
Jihane Balla, Carlotta Siddi, Maria Scherma, Paola Fadda, Paola Fadda, Simona Dedoni   +5 more
doaj   +1 more source

Bench to Bedside: Stability Studies of GMP Produced Trastuzumab-TCMC in Support of a Clinical Trial

Pharmaceuticals, 2015
The first-in-human phase 1 clinical radioimmunotherapy (RIT) trial with 212Pb-1,4,7,10-tetraaza-1,4,7,10-tetra-(2-carbamoylmethyl)-cyclododecane-trastuzumab (212Pb-TCMC-trastuzumab) was completed in October 2014 as a joint effort at the University of ...
Diane E. Milenic, Kwamena E. Baidoo, Martin W. Brechbiel   +2 more
doaj   +1 more source

Current Status of Research on Losartan in Tumour Therapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Losartan, a widely prescribed antihypertensive agent, has attracted growing interest as a potential adjuvant in cancer therapy due to its affordability, established safety profile and pleiotropic effects. Emerging preclinical evidence demonstrates that losartan can effectively modulate the tumour microenvironment (TME) by inhibiting ...
Han Wang, Shuang Yuan, Hongjing Wang
wiley   +1 more source

In Vivo Radionuclide Generators for Diagnostics and Therapy [PDF]

, 2016
In vivo radionuclide generators make complex combinations of physical and chemical properties available for medical diagnostics and therapy. Perhaps the best-known in vivo generator is 212Pb/212Bi, which takes advantage of the extended half-life of 212Pb
Edem, Patricia E., Fonslet, Jesper, Herth, Matthias, Kjær, Andreas, Severin, Gregory   +4 more
core   +3 more sources

Radiation‐Induced Biological Effects: Molecular and Cellular Mechanism, and Applications to Radiation/Nuclear Emergency and Cancer Therapy

MedComm, Volume 6, Issue 12, December 2025.
Radiation‐induced biological effects are an extremely complex and extensive mechanism that involves multiple aspects of physiological activities in organisms. In the medical field, utilizing the damaging effects of radiation to treat tumors is a commonly employed therapeutic approach.
Zhihe Hu, Yan Chen, Shengyi Yang, Shihai Diao, Le Ma, Chunmeng Shi   +5 more
wiley   +1 more source

Multifunctional Au@AgBiS2 Nanoparticles as High‐Efficiency Radiosensitizers to Induce Pyroptosis for Cancer Radioimmunotherapy

Advanced Science, 2023
Radiotherapy (RT), a widely used clinical treatment modality for cancer, uses high‐energy irradiation for reactive oxygen species (ROS) production and DNA damage.
Liang Xiao, Benjin Chen, Wanni Wang, Tian Tian, Haisheng Qian, Xiaohu Li, Yongqiang Yu   +6 more
doaj   +1 more source