Results 51 to 60 of about 12,534 (220)

Targeting of radiolabeled J591 antibody to PSMA-expressing tumors: optimization of imaging and therapy based on non-linear compartmental modeling [PDF]

, 2016
BACKGROUND: We applied a non-linear immunokinetic model to quantitatively compare absolute antibody uptake and turnover in subcutaneous LNCaP human prostate cancer (PCa) xenografts of two radiolabeled forms of the humanized anti-prostate-specific ...
Blesida Punzalan, Daniel E. Spratt, Darren R. Veach, Edward K. Fung, Jawaria Amir, Joseph R. Osborne, Neil H. Bander, Pat B. Zanzonico, Sandhya Chalasani, Sarah M. Cheal, Shoaib B. Fareedy, Steven M. Larson, Volkan Beylergil, Wolfgang A. Weber   +13 more
core   +1 more source

Advancements in Inorganic Chiral Nanomaterials for Anti‐Tumor Immunotherapy

Cancer Science, EarlyView.
Schematic illustration of how inorganic chiral nanomaterials enhance immune activation to promote tumor cell elimination through targeted delivery, immunogenic cell death, and immune microenvironment modulation. ABSTRACT While the past decade has witnessed unprecedented technological advancements, cancer remains a major health threat, with conventional
Siyu Chen, Qian Tang, Xiqian Chen, Yinghao Liang, Jin Qiu, Yongmei Liao, Changqiang Li, Hongru Yu, Fang Xie, Zongjunlin Liu   +9 more
wiley   +1 more source

Comparison of I-131 Radioimmunotherapy Tumor Dosimetry: Unit Density Sphere Model Versus Patient-Specific Monte Carlo Calculations [PDF]

, 2011
High computational requirements restrict the use of Monte Carlo algorithms for dose estimation in a clinical setting, despite the fact that they are considered more accurate than traditional methods.
Bolch WE, Cristy M, David M. Howard, Hartmann Siantar CL, Kimberlee J. Kearfott, Loevinger R, Prestwich WV, Schipper MJ, Scott J. Wilderman, Sgouros G, Stabin MG, Stabin MG, Yoriyaz H, Yuni K. Dewaraja   +13 more
core   +1 more source

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, Volume 32, Issue 17, 5 May 2026.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

Radioimmunotherapy for Acute Leukemia [PDF]

Cancer Control, 2002
The use of monoclonal antibodies to deliver radioactive isotopes directly to tumor cells has become a promising strategy to enhance the antitumor effects of native monoclonal antibodies. In this article, we summarize the role of radioimmunotherapy in the treatment of leukemia.The authors reviewed the published clinical trials of radioimmunotherapy in ...
John M, Burke, Joseph G, Jurcic, David A, Scheinberg   +2 more
openaire   +2 more sources

Early Diagnosis of Alzheimer's disease by NIRF Spectroscopy and Nuclear Medicine-v.4.0 [PDF]

, 2011
There is an urgent need for the early detection of diseases such as Alzheimer’s (AD) and Cancers in order to enable their successful treatment. Cancer is the second major cause of death after Heart Disease, and AD is the third major cause of death
I Baianu
core   +1 more source

Bench to Bedside: Stability Studies of GMP Produced Trastuzumab-TCMC in Support of a Clinical Trial

Pharmaceuticals, 2015
The first-in-human phase 1 clinical radioimmunotherapy (RIT) trial with 212Pb-1,4,7,10-tetraaza-1,4,7,10-tetra-(2-carbamoylmethyl)-cyclododecane-trastuzumab (212Pb-TCMC-trastuzumab) was completed in October 2014 as a joint effort at the University of ...
Diane E. Milenic, Kwamena E. Baidoo, Martin W. Brechbiel   +2 more
doaj   +1 more source

Therapeutic dendritic cell vaccines engineered with antigen‐biomineralized Bi2S3 nanoparticles for personalized tumor radioimmunotherapy

Aggregate, 2022
Therapeutic vaccines, an exciting development in cancer immunotherapy, share the goal of priming of personalized antigen‐specific T‐cell response by precise antigen presentation of dendritic cells (DCs), but major obstacles include insufficient antigen ...
Huan Yu, Haoxiang Guo, He Zu, Heng Ding, Subin Lin, Yangyun Wang, Leshuai W Zhang, Yong Wang   +7 more
doaj   +1 more source

A rapid microwave-assisted procedure for easy access to Nx polydentate ligands for potential application in α-RIT [PDF]

, 2010
International audienceHeterocycles bearing a hydrazine moiety react with bisaldehydes or bisketones to afford new Nx polydentate ligands suitable for α-radioimmunotherapy.
Bodio, E., Deniaud, D., Grosjean, S., Julienne, K., Meslin, J.-C., Montavon, Gilles,, Mével, M.   +6 more
core   +4 more sources

CD19+Ki67+B cells regulated by NAMPT as key modulators in triple-negative breast cancer with brain metastasis

Breast Cancer Research
Background Among breast cancer subtypes, triple-negative breast cancer (TNBC) stands out for its aggressiveness and high frequency of brain metastases. However, the mechanisms driving BrM remain poorly understood.
Qiyi Zhou, Zhimin zhu, Yuxin Zhao, Di Jing, Liyuan Zhang   +4 more
doaj   +1 more source