ABSTRACT Camizestrant is the next‐generation oral selective estrogen receptor degrader and complete estrogen receptor antagonist in Phase 3 development for hormone receptor‐positive breast cancer. To investigate the impact of manufacturing changes during pivotal Phase 3 studies, this open‐label, randomized crossover study of 32 postmenopausal healthy ...
Andy Sykes +15 more
wiley +1 more source
Emerging methods for subtype differentiation in primary aldosteronism
Abstract Primary aldosteronism (PA) is a common cause of hypertension. Compared to patients with essential hypertension, untreated PA is associated with a two‐ to fourfold greater risk of cardiovascular disease, renal failure, and death. PA is caused by increased secretion of aldosterone from one adrenal gland in 30% of the patients and both adrenal ...
Oskar Ragnarsson +5 more
wiley +1 more source
Scanning for Tumours with Radiolabeled Antibodies: A Review [PDF]
P W Dykes +2 more
openalex +1 more source
Functional characterization of NRT1/PTR FAMILY transporters: looking for a needle in a haystack
Summary NRT1/PTR FAMILY (NPF) transporters play crucial roles in plant physiology and development due to their involvement in nitrogen nutrition and their ability to transport multiple signaling molecules and metabolites. Whereas most eukaryotic and prokaryotic NPF orthologs are peptide transporters, most flowering plant NPF transport other substrates ...
Laura Morales de Los Ríos +6 more
wiley +1 more source
Tc-99m Radiolabeled Peptide p5 + 14 is an Effective Probe for SPECT Imaging of Systemic Amyloidosis
Stephen J. Kennel +4 more
openalex +1 more source
SWEET1‐mediated glucose transport is crucial for energy availability in Arabidopsis
Summary The stress‐responsive hormone abscisic acid (ABA) is known for its inhibitory effects on various physiological processes, including seed germination, often resulting in energy deprivation. Interestingly, ABA‐induced germination inhibition can be alleviated by exogenous glucose (Glc), mimicking a functional interplay between ABA and sugar ...
Xueyi Xue +3 more
wiley +1 more source
Aluminum-[<sup>18</sup>F]fluoride radiolabeling of triarylphosphines for cell labeling via the perfluoroaryl azide Staudinger ligation. [PDF]
Biti A +9 more
europepmc +1 more source
Togni reagent I, one of the most used electrophilic trifluoromethylating reagents, has been radiolabeled with fluorine‐18 starting from the widely available fluoro‐benziodoxole and the [18F]Ruppert–Prakash reagent. To demonstrate the broad potential for late‐stage functionalization, aliphatic carboxylic acids were successfully converted into their 18F ...
Lizeth Y. F. Haveman +2 more
wiley +1 more source
Extending the shelf life of ⁶⁸Ge/⁶⁸Ga generators via preconcentration of [⁶⁸Ga]GaCl₃ for preclinical application. [PDF]
Mallapura H, Eriksson O.
europepmc +1 more source
Noninvasive Detection of Plaque Instability with Use of Radiolabeled Annexin A5 in Patients with Carotid-Artery Atherosclerosis [PDF]
Bas Kietselaer +6 more
openalex +1 more source

