Results 91 to 100 of about 29,491 (205)

Transcriptional Profiling of Growth Hormone–Secreting Pituitary Adenoma Stem‐Like Cells: Unveiling the Significant Role of CXCR4 in Tumorigenesis and Clinical Applications

MedComm, Volume 7, Issue 9, September 2026.
Growth hormone–secreting pituitary adenomas harbor hPASCs (human pituitary adenoma stem‐like cells). Genetic profiling of hPASCs identified CXCR4 as a significant gene orchestrating a regulatory network in the self‐renewal and differentiation of hPASCs, as well as the modulation of tumor cells and the microenvironment.
LinHao Yuan, Hao Yang, BaoWang Li, Huimin Sui, Peiliang Li, Xu Wang, Jiang Li, Guijun Jia, Zhaohui Zhu, Deling Li, Wang Jia, Peng Kang   +11 more
wiley   +1 more source

Quantification of 10B and 11B in Biological Samples in Translational Science and Clinical Applications for Boron Neutron Capture Therapy (BNCT)

Medicinal Research Reviews, Volume 46, Issue 5, Page 1362-1389, September 2026.
ABSTRACT Boron neutron capture therapy (BNCT) is a targeted radiotherapy that exploits the selective accumulation of the 10B isotope within tumors, followed by irradiation with low‐energy neutrons to induce high linear energy transfer particles with short path lengths, resulting in localized tumor cell destruction while sparing surrounding healthy ...
Christoph Selg, Wolfgang A. G. Sauerwein, Evamarie Hey‐Hawkins   +2 more
wiley   +1 more source

Radionuclide therapy of hepatocellular carcinoma

Biomedical Imaging and Intervention Journal, 2006
Hepatocellular carcinoma (HCC) is a malignant tumour of the hepatocyte. It is a common malignancy worldwide and causes almost half a million deaths annually. Asia is a high risk area. Although surgery (hepatectomy or liver transplantation) is the main form of curative treatment, the majority of patients are not eligible for surgery due to extent of ...
openaire   +2 more sources

Prostate Cancer Development, Progression, and Therapy

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin, Zicheng Xiao, Zexian Ding, Wei Li, Ruijiang Zeng, Yujun Shuai, Weimin Ci, Dan Xia, Xu Zhang, Haojie Huang   +9 more
wiley   +1 more source

Dose modeling of superficial brachytherapy applicator geometries using multiple radioisotopes

Medical Physics, Volume 53, Issue 9, September 2026.
Abstract Background Superficial brachytherapy enables localized dose delivery for superficial cutaneous lesions, but conventional applicators may be limited in treating extended, irregular, or curved surfaces. Geometric constraints, gaps or overlaps between adjacent applicators, and placement‐related uncertainties can reduce dose uniformity ...
Jin Jegal, HyeoungWoo Park, Seonghee Kang, Jung‐in Kim, Chang Heon Choi, Siyong Kim   +5 more
wiley   +1 more source

Experimental activation assessment of open‐type yoke in a PET cyclotron by non‐destructive/destructive γ‐ray measurement approaches

Medical Physics, Volume 53, Issue 9, September 2026.
Abstract Background During decommissioning of positron emission tomography (PET) cyclotron facilities, metallic components—including the iron yoke—are typically classified as radioactive waste, incurring substantial disposal costs. In contrast to concrete, standardized decommissioning procedures for metallic components have not yet been established ...
Go Yoshida, Hiroshi Matsumura, Akihiro Toyoda, Hajime Nakamura, Kazuyoshi Masumoto, Taichi Miura, Eisuke Watanabe, Kiyokazu Tsugane, Katsuhiko Saito, Iwane Koumura, Hiroyuki Uno, Masahiko Kozaki, Ayumi Yamamoto, Jun Toyohara, Kei Wagatsuma   +14 more
wiley   +1 more source

Roadmap for the implementation of particle minibeam therapy

Medical Physics, Volume 53, Issue 9, September 2026.
Abstract Particle minibeam therapy (PMBT) has emerged as an advanced modality within spatially fractionated radiation therapy, using the physical properties of protons, ions, and electrons to achieve superior normal tissue sparing whilst preserving spatial dose distribution at depths that are unachievable in conventional kV or MV X‐rays.
Reem Ahmad, Oxana Actis, Adam H. Aitkenhead, Richard A. Amos, Niels Bassler, Catherine Burne, Pankaj Chaudhary, Gerd Datzmann, Umberto Deut, Fabio Di Martino, Rebecca Habgood, Simon Jolly, Emmanuel Jouglar, Eva Kasanda, Nigel Lee, Dominic Leiser, Xiangkun Li, Giuliana Milluzzo, Jessica Neubauer, Kelvin Ng Wei Siang, Hugo Palmans, Yolanda Prezado, Judith Reindl, Francesco Romano, Loris Roncali, Aikaterini Rousseti, Thomas E. Schmid, Ileana Silvestre Patallo, Frank Stephan, Anna Subiel, Edward Taylor, Annalisa Walpen, Samuel Flynn   +32 more
wiley   +1 more source

Quantitative SPECT imaging of 225Ac and its daughters in mice in vivo

Medical Physics, Volume 53, Issue 9, September 2026.
Abstract Background Targeted alpha therapy (TAT) using actinium‐225 (225Ac) holds great promise for cancer treatment, and to advance 225Ac therapy it is required to develop accurate dosimetry method. 225Ac daughters, especially 213Bi, may redistribute and cause renal toxicity.
Shixian Du, Kondapa Naidu Bobba, Robin Peter, Grant T. Gullberg, Robert R. Flavell, Javier Caravaca, Youngho Seo   +6 more
wiley   +1 more source

Azide‐PEG‐Folate Functionalized Gadolinium Nanoparticles: A Preliminary Click‐Chemistry Platform for Magnetic Resonance Imaging Contrast

ChemistryOpen, Volume 15, Issue 9, September 2026.
The click‐modified targeted gadolinium nanoparticles are presented as a development of a multifunctional MRI contrast agent. The nanoplatform demonstrates improved stability and selective cellular targeting, and is expected to facilitate more precise tumor imaging while enabling further bioorthogonal conjugation for advanced cancer diagnosis and ...
Retna Putri Fauzia, Azmi Aulia Rahmani, Zahra Afriani, Theresia Cicilia Magdalena, Cindy Florencia Sutanto, Galuh Yuliani, Angga Cipta Narsa, Safri Ishmayana, Ratna Dini Haryuni, Huanhuan Liu, Santhy Wyantuti   +10 more
wiley   +1 more source

Theranostic π Electron‐Stabilized Polymeric Micelles for PET Imaging‐Guided Drug Delivery to Tumors

Small, Volume 22, Issue 49, 1 September 2026.
Cancer nanomedicine efficacy is limited by heterogeneous nanoparticle accumulation in tumors. Nuclear imaging offers non‐invasive, patient‐ and lesion‐specific visualization and quantification of nanoparticle uptake. We present a positron emission tomography (PET)‐imageable micelle platform for direct quantification of nanoparticle accumulation and ...
Alec Wang, Alexandru Florea, Jan‐Niklas May, Zaheer Ahmed, Karolin Roemhild, Thomas Hansen, Rahaf Mihyar, Armin Azadkhah Shalmani, Laura Schäfer, Karolin Becker, Masoud Sadeghzadeh, Eva M. Buhl, Sven Thoröe‐Boveleth, Susanne Lütje, Agnieszka Morgenroth, Fabian Kiessling, Jochen Maurer, Josbert M. Metselaar, Yang Shi, Felix M. Mottaghy, Quim Peña, Twan Lammers   +21 more
wiley   +1 more source