Results 111 to 120 of about 22,462 (308)

Ionic Liquid Aided [11C]CO Fixation for Synthesis of 11C‐carbonyls

ChemistryOpen, EarlyView.
Tributyl(ethyl)phosphonium oxopentenolate ([P4442][Pen]) is an ionic liquid used in a proof‐of‐concept study evaluating its utility to trap carbon‐11 (t1/2=20.4 min)‐labeled CO for preparation of amides, ureas and carbamates. Abstract Tributyl(ethyl)phosphonium oxopentenolate ([P4442][Pen]) is an ionic liquid developed to capture CO and has shown ...
Anton Lindberg, Narges Mokhtarinori, Zhenzhen Yang, Sheng Dai, Ilja Popovs, Neil Vasdev   +5 more
wiley   +1 more source

Beyond Conventional Parametric Modeling: Data-Driven Framework for Estimation and Prediction of Time Activity Curves in Dynamic PET Imaging [PDF]

arXiv
Dynamic Positron Emission Tomography (dPET) imaging and Time-Activity Curve (TAC) analyses are essential for understanding and quantifying the biodistribution of radiopharmaceuticals over time and space. Traditional compartmental modeling, while foundational, commonly struggles to fully capture the complexities of biological systems, including non ...
arxiv  

Radiopharmacologist’s and Radiochemist’s View on Targeting the Eph/Ephrin Receptor Tyrosine Kinase System

ACS Omega, 2020
Christin Neuber, Birgit Belter, Constantin Mamat, Jens Pietzsch   +3 more
doaj   +1 more source

Interactions of rare earth elements with living organisms and emerging biotechnical applications

PLANTS, PEOPLE, PLANET, EarlyView.
Rare earth elements (REEs) are critical resources required to achieve net‐zero carbon emission targets and energy security. However, rising demand for REEs coupled with significant extraction and processing challenges and geopolitical risks restricts access to REE resources.
Samantha A. McGaughey, Shagufta Iqbal, Annamaria De Rosa, Jessica A. Caley, Anna H. Kaksonen, Denys Villa‐Gomez, Caitlin S. Byrt   +6 more
wiley   +1 more source

Uncertainty Propagation from Projections to Region Counts in Tomographic Imaging: Application to Radiopharmaceutical Dosimetry [PDF]

arXiv
Radiopharmaceutical therapies (RPTs) present a major opportunity to improve cancer therapy. Although many current RPTs use the same injected activity for all patients, there is interest in using absorbed dose measurements to enable personalized prescriptions.
arxiv  

Terbium-149 production: a focus on yield and quality improvement towards preclinical application

Scientific Reports
Terbium-149 (T1/2 = 4.1 h, Eα = 3.98 MeV (16.7%), 28 µm range in tissue) is a radionuclide with potential for targeted alpha therapy. Due to the negligible emission of α-emitting daughter nuclides, toxicity to healthy tissue may be reduced in comparison ...
C. Favaretto, P. V. Grundler, Z. Talip, U. Köster, K. Johnston, S. D. Busslinger, P. Sprung, C. C. Hillhouse, R. Eichler, R. Schibli, C. Müller, N. P. van der Meulen   +11 more
doaj   +1 more source

Incidental Brain Metastases From Prostate Cancer Diagnosed With PSMA PET/CT and MRI: A Case Series and Literature Review

The Prostate, EarlyView.
ABSTRACT Background Brain metastases (BMETS) from prostate cancer are rare. Hence, brain imaging in neurologically asymptomatic patients with advanced prostate cancer (aPC) is not routinely performed. Prostate‐specific membrane antigen (PSMA) PET/CT uses a radiotracer that binds to prostate cancer epithelial cells and is FDA‐approved for initial ...
Mark Willy L. Mondia, Prem P. Batchala, Robert Dreicer, Michael E. Devitt, Matthew R. McCord, Melike Mut, Jason P. Sheehan, David Schiff, Camilo E. Fadul   +8 more
wiley   +1 more source

st-DTPM: Spatial-Temporal Guided Diffusion Transformer Probabilistic Model for Delayed Scan PET Image Prediction [PDF]

arXiv
PET imaging is widely employed for observing biological metabolic activities within the human body. However, numerous benign conditions can cause increased uptake of radiopharmaceuticals, confounding differentiation from malignant tumors. Several studies have indicated that dual-time PET imaging holds promise in distinguishing between malignant and ...
arxiv  

Item Response Modeling and Artificial Neural Network for Differentiation of Parkinson's Patients and Subjects Without Evidence of Dopaminergic Deficit

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Approximately 15% of patients suspected of having Parkinson's disease (PD) present dopamine active transporter (DaT) scans without evidence of dopaminergic deficits (SWEDD), most of which will never develop PD. Leveraging Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) scores from the Parkinson's Progression ...
Leticia Arrington, Sven C. van Dijkman, Elodie L. Plan, Mats O. Karlsson   +3 more
wiley   +1 more source

Toward Personalized Immunotherapeutic Drug Monitoring with Multiplexed Extended‐Gate Field‐Effect‐Transistor Biosensors

Small Science, EarlyView.
In this study, a proof of concept is presented using an extended‐gate field‐effect‐transistor biosensing platform for monitoring immunotherapeutic drugs in vivo. Using varying sizes of immunotherapeutic drugs, the biosensor surpasses the sensitivity of standard methods, reducing the need for radioactive labeling in real‐time sensing.
Trang‐Anh Nguyen‐Le, Christin Neuber, Isli Cela, Željko Janićijević, Liliana Rodrigues Loureiro, Lydia Hoffmann, Anja Feldmann, Michael Bachmann, Larysa Baraban   +8 more
wiley   +1 more source