Results 101 to 110 of about 27,148 (204)

Radiopharmacologist’s and Radiochemist’s View on Targeting the Eph/Ephrin Receptor Tyrosine Kinase System

ACS Omega, 2020
Christin Neuber, Birgit Belter, Constantin Mamat, Jens Pietzsch   +3 more
doaj   +1 more source

High molar activity [11C]phosgene from [11C]CO2

EJNMMI Radiopharmacy and Chemistry
Background [11C]Phosgene is a known but underutilised labelling synthon in PET-tracer development. The production of [11C]phosgene faces many problems such as difficulties in achieving high molar activity, regular key component replacement and complexity
Edla Kerminen, Thomas Keller, Simo Salo, Johan Rajander, Olof Solin, Anna Krzyczmonik, Anna K. Kirjavainen   +6 more
doaj   +1 more source

A DPP6‐Targeted PET Tracer for Non‐Invasive Imaging of Transplanted Human Islets

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Dipeptidyl peptidase‐like protein 6 (DPP6) is a potential molecular imaging biomarker for pancreatic and transplanted islets of Langerhans. 4hD29 is a single‐domain antibody with nanomolar affinity for DPP6. Here, we demonstrate the generation and validation of [68Ga]Ga‐NOTA‐4hD29 for Positron Emission Tomography (PET) imaging of ...
Amina Khalil, Arturo Roca‐Rivada, Svitlana Vasylovska, Lorenzo J. I. Balestri, Irina Velikyan, Sayro Jawurek, Alexandra C. Title, Burcak Yesildag, Luke R. Odell, Joey Lau, Decio L. Eizirik, Olof Eriksson   +11 more
wiley   +1 more source

Multifactorial analysis of radiochemical purity in high-activity 177Lu-labeled theranostics: impact of precursor source, 177Lu form, and production parameters

EJNMMI Radiopharmacy and Chemistry
Background Lutetium-177 (177Lu) theranostics have revolutionized personalized cancer treatment, particularly with FDA-approved therapies like [177Lu]Lu-DOTA-TATE for neuroendocrine tumors and [177Lu]Lu-PSMA for prostate cancer.
William Hunt, Mathew Long, Usama Kamil, Sunil Kellapatha, Wayne Noonan, Peter D. Roselt, Nathan Papa, Brittany Emmerson, Michael S. Hofman, Mohammad B. Haskali   +9 more
doaj   +1 more source

Equine vegetative endocarditis and vertebral osteomyelitis due to refractory Erysipelothrix rhusiopathiae infection

Equine Veterinary Education, EarlyView.
Summary Erysipelothrix rhusiopathiae was the causative agent of vegetative endocarditis and vertebral osteomyelitis in a 24‐year‐old Irish draught gelding that presented with prolonged history of intermittent pyrexia and tachycardia. Clinical investigations revealed persistently reduced neck mobility, tachydysrhythmia and episodic pyrexia up to 41°C ...
E. Kolovou, Z. Daobry, Â. J. F. Mendes, G. Weller, S. Radhakrishnan, M. S. I. Sajib, M. Fuentes, F. Zendri, T. Forde, W. Weir, J. Del‐Pozo, D. G. M. Sutton   +11 more
wiley   +1 more source

Radiosynoviorthesis in People With Haemophilia—Pain‐Related and Clinical Outcomes: A Prospective Controlled Cohort Study

Haemophilia, EarlyView.
ABSTRACT Introduction Radiosynoviorthesis (RSO) may alleviate pain and clinical symptoms in people with haemophilia (PwH), however, controlled longitudinal data on these outcomes remain limited. Aim To evaluate the effects of RSO on pain, joint health, swelling, and treatment satisfaction over twelve months. Methods Patients with an indication for RSO (
Alexander Schmidt, Pia Möllers, Jamil Hmida, Marius Brühl, Barbara Boddenberg‐Pätzold, Hermann Eichler, Georg Goldmann, Björn Habermann, Susan Halimeh, Johannes Oldenburg, Heinrich Richter, Fabian Tomschi, Andreas C. Strauss, Thomas Hilberg   +13 more
wiley   +1 more source

Radiopharmaceutical transport in solid tumors via a 3-dimensional image-based spatiotemporal model

npj Systems Biology and Applications
Lutetium-177 prostate-specific membrane antigen (177Lu-PSMA)-targeted radiopharmaceutical therapy is a clinically approved treatment for patients with metastatic castration-resistant prostate cancer (mCRPC).
Anahita Piranfar, Farshad Moradi Kashkooli, Wenbo Zhan, Ajay Bhandari, Babak Saboury, Arman Rahmim, M. Soltani   +6 more
doaj   +1 more source

Impact of dose reduction and multi‐parametric harmonization on multi‐organ radiomics robustness in total‐body PET imaging: Methodological implications for quantitative theranostics [PDF]

Med Phys
Abstract Background Radiomic features derived from positron emission tomography (PET) are sensitive to count statistics and acquisition protocol variability, thereby limiting quantitative reliability in low‐dose and multi‐center total‐body PET imaging.
Azimi M, Cheraghi M, Zaidi H.
europepmc   +2 more sources

Eccentric Occlusal Loads Remodel the Dentoalveolar and Temporomandibular Biomechanical Unit in Rats

Journal of Oral Rehabilitation, EarlyView.
Eccentric occlusal loads remodel the dentoalveolar and temporomandibular joints in the masticatory biomechanical unit in rats. (A) Bite block as an occlusal rise (OR) on the rat maxillary first molar (green region) is shown. (B) 18F‐NaF Positron emission tomography localised regions of higher metabolic activity (higher uptake in the left condyle ...
Haochen Ci, Umama Ali, Zhiyuan Yang, Ayush Bakhandi, Nhu Huynh, Christine Nguyen, Brandon Lee, Youngho Seo, Robert Flavell, Alireza Hatamifar, Rishi J. Gupta, Rebeka Silva, Yongmei Wang, Bo Wang, Sunita P. Ho   +14 more
wiley   +1 more source

Targeting Cancer Stem Cells with Radioimmunotherapy: The Case of the Ovarian Cancer Stemness-Associated Biomarker L1CAM

International Journal of Translational Medicine
Cancer stem cells (CSCs) are a dynamic population of tumor cells characterized by long-term self-renewal, high tumorigenicity, resistance to conventional therapies such as radio- and chemotherapy, and capacity to recapitulate the tumor heterogeneity ...
Tihomir Zh. Todorov, Roger Schibli, Martin Béhé, Jürgen Grünberg   +3 more
doaj   +1 more source