Results 111 to 120 of about 27,148 (204)

Avian Eggshell Evolutionary Adaptations Inform Biomimetic Strategies for Next‑Generation Precision Cancer Theranostics

Advanced Oncology, Volume 1, Issue 1, December 2026.
ABSTRACT The avian eggshell is a sophisticated, multi‐functional biocomposite and, more importantly, an autonomous life‐support system evolved to safeguard embryonic development across dynamic and hostile environments. Discussing eggshell‐inspired biomaterials beyond simple structural imitation, this review translates these evolutionary survival ...
Zhiqiang Liu, Sida Ling, Mengqi Zhao, Chunyan Zhu, Yaoye Zhou, Hengquan Hou, Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Zuyong Wang, Swee Hin Teoh   +11 more
wiley   +1 more source

Hydrogel-Based Strategies for the Prevention and Treatment of Radiation-Induced Skin Injury: Progress and Mechanistic Insights

Biomimetics
Radiation-induced skin injury (RISI) is one of the most common complications of radiotherapy, severely compromising patients’ quality of life. However, no standardized treatment has yet been established.
Yinhui Wang, Huan Liu, Yushan He, Mei Li, Jie Gao, Zongtai Han, Jiayu Zhou, Jianguo Li   +7 more
doaj   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, Volume 159, Issue 11, Page 2633-2652, 1 December 2026.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

Quantitative studies in radiopharmaceutical science. Final report, January 1, 1993--December 31, 1993

, 1996
This report briefly summarizes published research at the University of Chicago in the area of quantitative studies in radiopharmaceutical science covering radiochemistry and PET/MRI ...
Beck, R.N., Cooper, M.
core   +1 more source

Optimized production of 89Zr as a medical radioisotope on a variable energy cyclotron and external beam-line

EJNMMI Physics
Background Zirconium-89 (89Zr) is a highly valued diagnostic radionuclide for positron emission tomography (PET) due to its long physical half-life of 78.4 h and decay characteristics, being preferred for the radiolabelling of nanoparticles and slow ...
Diana Cocioabă, Simona Baruta, Liviu Crăciun, Radu Leonte, Andrei Necsoiu, Maria-Roxana Tudoroiu-Cornoiu, Alexandru Jipa, Dana Niculae   +7 more
doaj   +1 more source

Development of Radioiodinated Tetrahydropyrazolopyridine Inhibitors Targeting mIDH

Journal of Labelled Compounds and Radiopharmaceuticals, Volume 69, Issue 13-14, November-December 2026.
Iodinated tetrahydropyrazolopyridine ligands show enhanced potency and selectivity for mutant IDH1 compared with their fluorinated counterparts and can be efficiently radiolabeled with I‐125, supporting the basis for further evaluation as mIDH1‐targeting radiotheranostic candidates.
Sarandeep Kaur, Sladjana Dukic‐Stefanovic, Lucie Arnaud, Jean‐Michel Chezal, Barbara Wenzel, Rareş‐Petru Moldovan, Klaus Kopka, Aurélie Maisonial‐Besset   +7 more
wiley   +1 more source

Chelator impact: investigating the pharmacokinetic behavior of copper-64 labeled PD-L1 radioligands

EJNMMI Radiopharmacy and Chemistry
Background Programmed cell death ligand 1 (PD-L1) plays a critical role in the tumor microenvironment and overexpression in several solid cancers has been reported. This was associated with a downregulation of the local immune response, specifically of T-
Fabian Krutzek, Cornelius K. Donat, Sven Stadlbauer   +2 more
doaj   +1 more source

In Vitro Characterization of the Published Glypican-3-Targeting Peptide TJ12P2 Reveals a Lack of Specificity and Potency

Pharmaceuticals
Background/Objectives: The cell surface proteoglycan glypican-3 (GPC3) is reportedly overexpressed in hepatocellular carcinoma (HCC) tissues, but not in benign liver tissues, rendering this protein a potential target for radionuclide theranostic ...
Eva-Maria Burger, Charlice Hill, Robert Wodtke, Kristof Zarschler, Markus Laube, Cornelius K. Donat, Sandra Hauser, Klaus Kopka, Jens Pietzsch, Sven Stadlbauer   +9 more
doaj   +1 more source

Copper‐Mediated Radiofluorination of the Excitatory Amino Acid Transporter 2 (EAAT2)–Targeted PET Tracer [18F]RP‐115: Alternate Synthetic Method

Journal of Labelled Compounds and Radiopharmaceuticals, Volume 69, Issue 13-14, November-December 2026.
An efficient two‐step radiosynthesis of [18F]RP‐115 was developed using copper‐mediated radiofluorination (CMRF) followed by deprotection. In a total 70‐min synthesis time, this approach provided [18F]RP‐115 in high radiochemical yield (52.8% ± 2.1%, decay corrected from stating [18F]fluoride ion) with high molar activity (355 ± 61 GBq/μmol) and ...
Sang Hee Lee, Joseph Blecha, Jung Min Kim, Ryan Michael Nillo, Robert R. Flavell, Chih‐Kai Chao, John R. Forsayeth, John M. Gerdes, Henry F. VanBrocklin, David M. Wilson   +9 more
wiley   +1 more source

Global Efforts to Reduce Paediatric Cancer Care Disparities in Radiotherapy: A Decade Change

Pediatric Blood &Cancer, Volume 73, Issue 11, November 2026.
ABSTRACT Background We present an update on the status, needs and challenges faced by paediatric imaging and radiotherapy (RT) programmes globally after a previous survey conducted by the International Atomic Energy Agency (IAEA) 10 years prior. Methods We developed and distributed a 121‐question survey to radiation oncologists, medical physicists and ...
Raymond B. Mailhot Vega, Daniel J. Indelicato, Jeanette Parkes, Natia Esiashvili, Josué Hernández Benítez, Miriam Mikhail‐Lette, Olivera Cirajc Bjelac, Daniel Berger, Eva Ciurana, Yavuz Anacak, Lisbeth Cordero‐Mendez   +10 more
wiley   +1 more source