Results 121 to 130 of about 34,120 (225)

Focal Spot, Summer 2002 [PDF]

, 2002
https://digitalcommons.wustl.edu/focal_spot_archives/1091/thumbnail ...

core   +1 more source

Bismuth Bicycles

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
Discovery, evolution and potential future applications of bismuth bicycle molecules—a novel class of therapeutics with unique properties. ABSTRACT Bicyclic peptides are emerging as next generation therapeutics by combining the affinity and specificity of antibodies with the synthetic convenience of small molecules.
Saan Voss, Amin Sagar, Arnaud Tiberghien, Richard J. L. Hughes, Liuhong Chen, Inmaculada Rioja, Mark Frigerio, Michael J. Skynner, David R. Spring   +8 more
wiley   +1 more source

Long‐term amyloid PET and MRI outcomes in a menopausal hormone therapy trial

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Associations of short‐term use of menopausal hormone therapy (mHT) with Alzheimer's disease (AD) and structural magnetic resonance imaging (MRI) biomarkers were investigated 10 years after an mHT trial. METHODS Recently menopausal women with good cardiovascular health were randomized to oral conjugated equine estrogens (oCEE) or ...
Kejal Kantarci, Firat Kara, Nirubol Tosakulwong, Angela J. Fought, Christopher G. Schwarz, Matthew L. Senjem, June Kendall‐Thomas, Paul Min, Val J. Lowe, Clifford R. Jack, Ekta Kapoor, Julie A. Fields, Kent R. Bailey, Taryn T. James, Laura Faubion, Rogerio A. Lobo, JoAnn E. Manson, Lubna Pal, Dustin B. Hammers, Eliot A. Brinton, Michael Malek‐Ahmadi, Marcelle I. Cedars, Frederick N. Naftolin, Nanette Santoro, Virginia M. Miller, Sherman M. Harman, N. Maritza Dowling, Carey E. Gleason   +27 more
wiley   +1 more source

Association between brain volume and depression in Alzheimer's disease: Neuroimaging insights

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) often co‐occurs with depression, affecting cognitive function and quality of life. Understanding the neurobiological links between brain abnormalities and depressive symptoms is essential for effective treatment.
Chao Tang, Jiaxin Yang, Xiaoyang Lei, Ming Zhang, Yi Chen, Xiaoxue Peng, Dian He   +6 more
wiley   +1 more source

Alzheimer's clinical research data via R packages: The alzverse

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Sharing clinical research data is essential for advancing Alzheimer's disease (AD) research, yet challenges in accessibility, standardization, documentation, usability, and reproducibility persist. METHODS We developed R data packages to streamline access to curated datasets from key AD studies. A4LEARN includes data from the Anti‐
Michael C. Donohue, Kedir Hussen, Oliver Langford, Richard Gallardo, Gustavo Jimenez‐Maggiora, Paul S. Aisen, for the Alzheimer's Disease Neuroimaging Initiative   +6 more
wiley   +1 more source

Falls predict faster progression to Alzheimer's dementia

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION In preclinical Alzheimer's disease (AD), amyloid accumulates in the brain while individuals remain cognitively unimpaired (Clinical Dementia Rating® [CDR] = 0). Differentiating trajectories of healthy aging and preclinical AD is challenging as both are associated with age‐related impairments (e.g., falls).
Audrey A. Keleman, Melody Li, Julie K. Wisch, Rebecca M. Bollinger, Melissa J. Krauss, Elizabeth A. Grant, Tammie L. S. Benzinger, Beau M. Ances, John C. Morris, Susan L. Stark   +9 more
wiley   +1 more source

Potential Targets and Biomarkers of Radionuclide Therapy in Breast Cancer

Cancer Innovation, Volume 5, Issue 1, February 2026.
Potential biomarkers for the development of targeted radionuclide therapy that can be employed in the treatment of breast cancer have been summarised in the review. They include receptor markers of ER, PR and HER2, as well as other markers of Trop2, PD‐1, EGFR, GRPR and PSMA.
Yujing Tan, Cheng Zeng, Jiani Wang, Fei Ma   +3 more
wiley   +1 more source

Programmable Microwaveable Chemistry in the Chemputer

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
The Chemputer integrates complementary microwave modules under χDL control, enabling fully automated syntheses of O‐alkylation products, Suzuki–Miyaura cross‐couplings, ring‐closing metathesis, and peptide sequences via solid‐phase methods. This modular, programmable platform delivers flexible and scalable microwave‐assisted workflows, broadening ...
Jacopo Zero, Ekaterina Trushina, Niclas Grocholski, Nikita Smirnov, Dean Thomas, Leroy Cronin   +5 more
wiley   +2 more sources

Integrative single‐cell analysis uncovers distinct tumour microenvironment ecotypes and immune evasion across skin cancers

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Graphical highlights Tumour subpopulations with high malignancy show reduced interferon signalling and reduced MHC‐I expression. Tumour‐associated macrophages (TAMs) differentiate into two opposing states: SPP1+ TAMs and CXCL9+ TAMs. Among immune ecotypes, T‐cell‐enriched ecotypes are linked with high MHC‐I expression in tumour cells while desert ...
Lingjuan Huang, Huihui Hou, Xiyuan Zhang, Liang Dong, Wensheng Shi, Mason Liu, Jie Sun, Anil Prakash, Haoqiu Song, Shiyao Pei, Xin Li, Xiang Chen, Shenglin Mei, Mingzhu Yin   +13 more
wiley   +1 more source

Biodistribution and Imaging of the 99mTc-Glutathione Radiopharmaceutical in White Rats Induced with Cancer [PDF]

, 2013
99mTc-glutathione (99mTc-GSH) is a radiopharmaceuticalwhich is potentially used as a cancer diagnostic kit. As with other radiopharmaceuticals, before applied in humans, including in clinical trials, 99mTc-GSH needs to go through a series of preclinical ...
Iswahyudi, I. (Iswahyudi), Wongso, H. (H), Zainuddin, N. (N)   +2 more
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