Results 131 to 140 of about 34,120 (225)

18F‐Radiopharmaceutical Diversification Enabled by Deaminative Cross‐Electrophile Couplings

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
A general Ni‐mediated (C)sp2–(C)sp3 cross‐coupling expedites access to 18F‐radiopharmaceuticals, essential for positron emission tomography imaging and drug discovery. This late‐stage diversification approach was implemented across three user‐friendly automated protocols affording 18F‐radiotracers in sufficient quantities for imaging.
Isabella F. Ogilvy, Joseph Ford, Sebastiano Ortalli, Evelien Renders, Thomas R. Hayes, Shuanglong Liu, Inne Mortiers, Anastasia Nikolopoulou, Alexandre M. Sorlin, Andrés A. Trabanco, Matthew Tredwell, Peter J. J. A. Buijnsters, Rhys Salter, Véronique Gouverneur   +13 more
wiley   +2 more sources

Is traumatic and non-traumatic neck pain associated with brain alterations? : a systematic review [PDF]

, 2017
Background: Chronic neck pain affects 50% - 85% of people who have experienced an acute episode. This transition and the persistence of chronic complaints are believed to be mediated by brain alterations among different central mechanisms.
Caeyenberghs, Karen, Cagnie, Barbara, Coppieters, Iris, Danneels, Lieven, De Pauw, Robby, Meeus, Mira   +5 more
core  

Exploring CPP Enhanced Hypoxia Targeting: An Approach Using Radiolabeled 2‐nitroimidazole TAT Conjugate

Drug Development Research, Volume 87, Issue 1, February 2026.
ABSTRACT Mediated by their protein transduction domain, cell‐penetrating peptides (CPPs) have been widely explored for facilitating intracellular delivery of drugs and small molecules. In this study, a radiolabeled, 2‐nitroimidazole conjugated TAT (TAT ‐ transactivator of transcription) peptide was prepared and evaluated for targeting tumor hypoxia ...
Sweety Mittal, Akanksha Jain, Ashwini Babu, Chandan Kumar, Madhava B. Mallia   +4 more
wiley   +1 more source

Associations Between Growth Differentiating Factor‐15 and Frailty in Older Adults From the MAPT Study

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Frailty is a prevalent syndrome in older adults and is associated with increased vulnerability to adverse health outcomes. Growth differentiation factor 15 (GDF‐15), a cytokine involved in mitochondrial dysfunction and inflammation, has been proposed as a potential biomarker for age‐related conditions.
Juan Luis Sánchez‐Sánchez, Yves Rolland, Alexandre Lucas, Sophie Guyonnet, Bruno Vellas, Philipe de Souto Barreto, for the MAPT/DSA Group   +6 more
wiley   +1 more source

Therapeutic Effects of Noninvasive Electrical Stimulation in Combination Transplantation of Human Adipose‐Derived Stem Cells‐Derived Dopaminergic Neuron on the Monkey Model of Parkinson's Disease

MedComm, Volume 7, Issue 2, February 2026.
Our results showed that noninvasive electrical stimulation (NES) alone or in combination with human adipose‐derived stem cells (hADSCs)‐induced dopaminergic neuron (NES‐DN) improved the behavioral deficits and pathological features of the MPTP‐induced PD monkey model.
Chunhui Huang, Shane Gao, Xiao Zheng, Xichen Song, Jiaxi Wu, Kai Liao, Jiawei Li, Yingqi Lin, Caijuan Li, Yaqun Lu, Jiahao Feng, Huiyi Wei, Lu Wang, Hao Xu, Wei Wang, Yizhi Chen, Jianhao Wu, Jiale Gao, Junzhu Song, Chunxiang Shi, Jun Zhang, Sen Yan   +21 more
wiley   +1 more source

Terbium-149 production: a focus on yield and quality improvement towards preclinical application

Scientific Reports
Terbium-149 (T1/2 = 4.1 h, Eα = 3.98 MeV (16.7%), 28 µm range in tissue) is a radionuclide with potential for targeted alpha therapy. Due to the negligible emission of α-emitting daughter nuclides, toxicity to healthy tissue may be reduced in comparison ...
C. Favaretto, P. V. Grundler, Z. Talip, U. Köster, K. Johnston, S. D. Busslinger, P. Sprung, C. C. Hillhouse, R. Eichler, R. Schibli, C. Müller, N. P. van der Meulen   +11 more
doaj   +1 more source

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

Gold Nanoparticles Loaded With Lutetium‐177 Labeled DOTA‐TATE Exhibit Superior AR42J Cell Affinity and Extended Blood Circulation in AR42J Tumor Xenografts

Nano Select, Volume 7, Issue 2, February 2026.
The present study reports the development of a gold nanoparticle‐based delivery system functionalized with the established radiopharmaceutical [177Lu]Lu‐DOTA‐TATE. This design aims to enhance tumor‐targeting efficacy and improve the overall in vivo pharmacokinetic profile. In vitro studies demonstrated enhanced specificity toward somatostatin receptor (
Dheeraj Kumar, Rani Gnanasekar, Sheela Muralidharan, Shubhangi Mirapurkar, Krishna Mohan Repaka, Anupam Mathur, Madhava B. Mallia   +6 more
wiley   +1 more source

Toward Personalized Immunotherapeutic Drug Monitoring with Multiplexed Extended‐Gate Field‐Effect‐Transistor Biosensors

Small Science
The selection and optimization of therapies for cancer patients urgently need personalization. Portable point‐of‐care electronic biosensors emerge as a groundbreaking solution contributing to better decision‐making in precision oncology.
Trang‐Anh Nguyen‐Le, Christin Neuber, Isli Cela, Željko Janićijević, Liliana Rodrigues Loureiro, Lydia Hoffmann, Anja Feldmann, Michael Bachmann, Larysa Baraban   +8 more
doaj   +1 more source

Effectiveness and Safety of Radium‐223 for Bone‐Metastatic Castration‐Resistant Prostate Cancer: The KYUCOG‐1901 Study

Cancer Science, Volume 117, Issue 2, Page 501-510, February 2026.
The KYUCOG‐1901 prospective multicenter study evaluated radium‐223 in 93 Japanese patients with bone‐metastatic castration‐resistant prostate cancer. Ra‐223 was well tolerated, produced meaningful declines in ALP, and yielded a median overall survival of 23.0 months. Early initiation in patients with lower disease burden and integration with subsequent
Masaki Shiota, Shuichi Tatarano, Tomomi Kamba, Toshiyuki Kamoto, Tsukasa Igawa, Naoya Masumori, Hirotsugu Uemura, Kensuke Mitsunari, Takayuki Sumiyoshi, Hiroji Uemura, Katsuyoshi Higashijima, Shoji Tokunaga, Masatoshi Eto   +12 more
wiley   +1 more source