Results 161 to 170 of about 7,465 (248)
Lifespan Trajectories of Asymmetry in White Matter Tracts
Human Brain Mapping, Volume 47, Issue 8, June 1, 2026.(A) Large‐scale lifespan modeling of white matter asymmetry. Diffusion MRI data from 35,000+ individuals (0‐100 years) across 50 cohorts were used to generate normative lifespan trajectories of white matter asymmetry. Thirty bilateral tracts were segmented, and microstructural (FA, MD, AD, RD) and macrostructural (volume, length) features were ...Sam Bogdanov, Praitayini Kanakaraj, Michael E. Kim, Jessica Samir, Chenyu Gao, Karthik Ramadass, Gaurav Rudravaram, Nancy R. Newlin, Derek Archer, Timothy J. Hohman, Angela L. Jefferson, Victoria L. Morgan, Alexandra Roche, Dario J. Englot, Susan M. Resnick, Lori L. Beason Held, Laurie E. Cutting, Laura A. Barquero, Micah A. D'Archangel, Tin Q. Nguyen, Kathryn L. Humphreys, Yanbin Niu, Sophia Vinci‐Booher, Carissa J. Cascio, The HABS‐HD Study Team, Alzheimer's Disease Neuroimaging Initiative, The BIOCARD Study Team, Sid E O'Bryant, Kristine Yaffe, Arthur Toga, Robert Rissman, Leigh Johnson, Meredith Braskie, Kevin King, James R Hall, Melissa Petersen, Raymond Palmer, Robert Barber, Yonggang Shi, Fan Zhang, Rajesh Nandy, Roderick McColl, David Mason, Bradley Christian, Nicole Phillips, Stephanie Large, Joe Lee, Badri Vardarajan, Monica Rivera Mindt, Amrita Cheema, Lisa Barnes, Mark Mapstone, Annie Cohen, Amy Kind, Ozioma Okonkwo, Raul Vintimilla, Zhengyang Zhou, Michael Donohue, Rema Raman, Matthew Borzage, Michelle Mielke, Beau Ances, Ganesh Babulal, Jorge Llibre‐Guerra, Carl Hill, Rocky Vig, Zhiyuan Li, Simon N. Vandekar, Panpan Zhang, John C. Gore, Stephanie J. Forkel, Bennett A. Landman, Kurt G. Schilling +72 morewiley +1 more sourcePET/CT and PET/MRI in Cancer Diagnosis and Management: A Comparative Clinical Perspective
iMetaMed, Volume 2, Issue 2, June 2026.This review compares PET/CT and PET/MRI in cancer imaging, highlighting their complementary roles for precise diagnosis and staging. It evaluates their technical strengths, clinical performance across various cancers, and future directions, including AI and novel tracers.Zijian Ding, Ran Xue, Qianxi Jin, Wangzheqi Zhang, Yali Wu, Baixuan Xu +5 morewiley +1 more sourceIncreased Serum Neurofilament Light Chain Levels in Parkinson's Disease Patients Carrying the p.A53T SNCA Mutation: Data from the Parkinson's Progression Markers Initiative Study
Movement Disorders, Volume 41, Issue 6, Page 1580-1585, June 2026.Abstract Background
Serum neurofilament light chain (NfL) levels, a marker of axonal damage, are generally elevated in neurodegenerative conditions, but results in idiopathic Parkinson's disease (iPD) have been inconsistent. The p.A53T SNCA mutation usually leads to a severe form of PD.Nikolaos Papagiannakis, Christos Koros, Athina‐Maria Simitsi, Leonidas Stefanis, and The Parkinson's Progression Markers Initiative, Kenneth Marek, Tanya Simuni, Andrew Siderowf, Caroline Tanner, Thomas F Tropea, Tatiana Foroud, Lana Chahine, Brit Mollenhauer, Kalpana Merchant, Douglas Galasko, Christopher Coffey, Kathleen Poston, Roseanne Dobkin, Ethan Brown, Roy Alcalay, Dan Weintraub, Emily Flagg, Kimberly Fabrizio, Susan Bressman, Cornelis Blauwendraat, Paola Casalin, Sonya Dumanis, Raymond James, Karl Kieburtz, Sneha Mantri, Werner Poewe, Michael Schwarzschild, John Seibyl, David Standaert, Duygu Tosun‐Turgut, Sohini Chowdhury, Jamie Eberling, Mark Frasier, Leslie Kirsch, Katie Kopil, Maggie Kuhl, Alyssa O'Grady, Todd Sherer, Tawny Willson, Tanya Simuni, Bridget McMahon, Craig Stanley, Kim Fabrizio, Dixie Ecklund, Christine Kohnen, Tatiana Foroud, Laura Heathers, Christopher Hobbick, John Seibyl, Christopher Coffey, Chelsea Caspell‐Garcia, Michael Brumm, Arthur Toga, Karen Crawford, Tatiana Foroud, Jan Hamer, Brit Mollenhauer, Doug Galasko, Kalpana Merchant, Andrew Singleton, Tatiana Foroud, Dirk Keene, Caroline Tanner, Ethan Brown, Carlie Tanner, Ethan Brown, Lana Chahine, Roseann Dobkin, Monica Korell, Neha Prakash, Tanya Simuni, Nabila Dahodwala, Caroline Tanner, Lana Chahine, Brit Mollenhauer, Sebastian Schade, Douglas Galasko, Anat Mirelman, Roy Alcalay, Katherine Leaver, Marie Saint‐Hilaire, Ruth Schneider, Christopher Tarolli, Werner Poewe, Aleksandar Videnovic, David Standaert, Marissa Dean, Sonja Jonsdottir, Rejko Krueger, Claire Pauly, Stewart Factor, Penelope Hogarth, Robert Hauser, Amy Amara, Michelle Fullard, Cyrus Zabetian, Hubert Fernandez, Kathrin Brockmann, Isabel Wurster, Yen Tai, Paolo Barone, Marina Picillo, Stuart Isaacson, Alberto Espay, Eduardo Tolosa, Javier Ruiz Martinez, Leonidas Stefanis, Kelvin Chou, Lorraine Kalia, Connie Marras, David Grimes, Tiago Mestre, Rajesh Pahwa, Mark Lew, Holly Shill, Shyamal Mehta, Giulietta Riboldi, Nikolaus McFarland, Ron Postuma, Zoltan Mari, David Ledingham, Nicola Pavese, Michele Hu, Norbert Brueggemann, Christine Klein, Bastiaan Bloem, Cristina Simonet, Alastair Noyce, Anette Janzen, David Pedrosa, Wolfgang Oertel, Njideka Okubadejo, David Shprecher, Arjun Tarakad, Emile Moukheiber, Joy Antala, Carla Aranda, Karen Williams, Sophia Melton, Karina Benson, Ashwini Ramachandran, Danielle Potts, Grace LaMoure, Ritikha Vengadesh, Ryan Manzler, Jaime Heller, Primi Ranola, Farah Kausar, Sherri Mosovsky, Diana Willeke, Elizabeth Kalinkara Gomez, Janelle Rodriguez, Nobuko Kemmotsu, May Eshel, Deborah Raymond, Abigail Desrosiers, Raymond James, Lauren Jackson, Iris Egner, Wesley Schlett, Courtney Blair, Lauren Ruffrage, Berenice Sevilla, Barbara Sommerfeld, Dustin Le, Erica Botting, Gabriella Mazur, Daniele Derlein, Evan Doll, Ying Liu, Ciera Cobb, Olivia Masiewicz, Jennifer Mule, Michael Morsillo, Ella Hilt, Aldazier Jakiran, Dominga Valentino, Lisbeth Pennente, Bobbie Stubbeman, Alicia Garrido, Valeria Ravasi, Ioana Croitoru, Christos Koros, Nikolas Papagiannakis, Frank Ferrari, Mengyu Zheng, Shawna Reddie, Alicia Alejandra, Andrea Gray, Alejandra Valenzuela, Caitlin Goodman, Sara Dresler, Neil Santos, Fahrial Esha, Kyle Rizer, Nadine Zablith, Liliana Dumitrescu, Debra Galley, Victoria Kate Foster, Jamil Razzaque, Madita Grümmer, Yara Krasowski, Natalie Donkor, Elisabeth Sittig, Oluwadamilola Ojo, Kelly Clark, Rory Mahabir, Kori Ribb, Shamera Willoughby +213 morewiley +1 more sourceInvestigation of a Radio-Iodinated Alpha-Mangostin for Targeting Estrogen Receptor Alpha (ERα) in Breast Cancer: In Silico Design, Synthesis, and Biological Evaluation
Drug Design, Development and TherapyMuchtaridi Muchtaridi,1,2 Wiwit Nurhidayah,1 Taufik Muhammad Fakih,1,3 Kento Kannaka,4 Hiroyuki Suzuki,4 Toto Subroto,5 Tomoya Uehara4 1Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Muchtaridi M, Nurhidayah W, Fakih TM, Kannaka K, Suzuki H, Subroto T, Uehara T +6 moredoaj Synthesis and Evaluation of 99mTc Essential Analogue of DUPA PSMA Inhibitor for Its Potential Use in Prostate Cancer Imaging
ChemistrySelect, Volume 11, Issue 21, 4 June 2026.ABSTRACT
DUPA (2‐[3‐(1,3‐dicarboxy propyl) ureido] pentanedioic acid) is a known small molecule prostate‐specific membrane antigen (PSMA) enzyme inhibitor that targets the PSMA receptor found overexpressed on prostate cancer. The present work synthesizes and evaluates a 99mTc (technetium) “metal essential” glutamate complex, which mimics the DUPA ...Navin Sakhare, Sheela Muralidharan, Dheeraj Kumar, Shubhankar Dutta, Rani Gnanasekar, Shalaka Paradkar, Arpit Mitra, Bhabani Mohanty, Shubhangi Mirapurkar, Anupam Mathur, Pradip R. Chaudhari, Kakoli Bose +11 morewiley +1 more sourceRational Design and Development of Organic Afterglow Nanoparticles for Image‐Guided Interventions
Small Methods, Volume 10, Issue 12, 23 June 2026.This review outlines the rational design, synthesis, and standardized characterization of organic afterglow nanoparticles for biomedical imaging and therapy. Mechanistic insights into chemically initiated electron exchange luminescence and reactive oxygen species‐mediated processes are connected to molecular engineering and nanoparticle fabrication ...Asma Harun, Isabella Vasquez, Hannah Bowman, Robert Posey, Zhongkui Hong, Joshua Tropp, Indrajit Srivastava +6 morewiley +1 more sourceCheckpoint inhibitors, obinutuzumab plus PET‐adapted ultra‐low dose nodal radiotherapy yield high efficacy in treatment‐naïve follicular lymphoma: Results from the phase II ‘FLUORO’ study
British Journal of Haematology, Volume 208, Issue 6, Page 2026-2035, June 2026.Summary
Follicular lymphoma (FL) first‐line chemoimmunotherapy yields high efficacy but serious toxicity in 65% of patients. In high tumour burden treatment‐naïve FL, we aimed to exploit known immunostimulatory and cytotoxic properties of combination checkpoint inhibition (atezolizumab) and obinutuzumab (6 cycles) with positron emission tomography (PET)Arina Martynchyk, Geoffrey Chong, Richard Khor, Denise Lee, Sze Ting Lee, Andrew M. Scott, Anneke C. Grobler, Belinda A. Campbell, Thanuja Thachil, Kate Manos, Genevieve Douglas, Alexandra Romano, Jodie B. Palmer, Melinda Burgess, Colm Keane, Eliza A. Hawkes +15 morewiley +1 more sourceHuman Absorption, Metabolism, and Excretion (hAME) Mass Balance Studies in Patients With Cancer
Clinical and Translational Science, Volume 19, Issue 6, June 2026.ABSTRACT
Radiolabeled mass balance human studies are a critical component of clinical pharmacology programs supporting the development of new investigational drugs. These studies provide information about absorption, metabolism, and excretion (AME) of the parent drug and metabolite(s) in the human body and are normally conducted in healthy volunteers ...Begoña de las Heras, Claudine Oelke, Pamela Atwell, Hector Herrero, Paulo Nunes, Kamal S. Saini, Laura Vidal Boixader, Catherine Laing, James Bush, Emiliano Calvo +9 morewiley +1 more source
