Results 1 to 10 of about 34,187 (225)

Potentials and practical challenges of terbium-161 labeled radiopharmaceuticals. [PDF]

EJNMMI Radiopharm Chem
Ntihabose CM, Handula M, Piet A, Beekman S, van Dalen L, Eskandari N, Aydogan A, Stuurman D, de Ridder C, Konijnenberg M, Seimbille Y, de Blois E.   +11 more
europepmc   +3 more sources

Synthesis and comparative evaluation of 177Lu-labeled PEG and non-PEG variant peptides as HER2-targeting probes

Scientific Reports, 2022
Highest global cancer incidence of female breast cancer is a matter of great concern. HER2-positive breast cancers have high mortality rate hence detection at an early stage is vital for successful treatment, improved cancer care and survival rate ...
Amit Kumar Sharma, Rohit Sharma, Kusum Vats, Haladhar Dev Sarma, Archana Mukherjee, Tapas Das, Drishty Satpati   +6 more
doaj   +1 more source

Preparation and Preliminary Imaging of Novel Albumin-Binding PSMA Ligand ［177Lu］Lu-DOTA-CPN-PSMA

He huaxue yu fangshe huaxue, 2023
A novel PSMA targeting molecule ［177Lu］Lu-DOTA-CPN-PSMA with high uptake and long retention in prostate cancer was developed, in which DOTA was used as the bifunctional chelator, glutamic acid-urea-lysine(Glu-Urea-Lys) was used as the targeting group ...
LUO Tian-wei, SUN Ming-yue, ZHANG Wen-hui, GAO Fei, WANG Ning, HUANG Xu-hu, CHEN Huan, LI Hong-yu   +7 more
doaj   +1 more source

Electrochemical separation and purification of no-carrier-added 177Lu for radiopharmaceutical preparation: Translation from bench to bed

Chemical Engineering Journal Advances, 2023
The entry of no-carrier-added (NCA) 177Lu in the arena of clinical nuclear medicine has revolutionized the practice of targeted radionuclide tumor therapy.
Sourav Patra, Rubel Chakravarty, Khajan Singh, K.V. Vimalnath, Sudipta Chakraborty   +4 more
doaj   +1 more source

Fast Fluorine-18 labeling and preclinical evaluation of novel Mucin1 and its Folate hybrid peptide conjugate for targeting breast carcinoma

EJNMMI Radiopharmacy and Chemistry, 2021
Background There is a need to develop new and more potent radiofluorinated peptide and their hybrid conjugates for multiple-receptors targeting properties that overexpress on many cancers.
I. Al Jammaz, B. Al-Otaibi, Y. Al-Malki, A. Abousekhrah, S. M. Okarvi   +4 more
doaj   +1 more source

Preparation and Bioevaluation of a Novel ^99mTc-Labeled Glucose Derivative Containing Cyclohexane as a Promising Tumor Imaging Agent

Pharmaceuticals, 2023
To develop novel tumor imaging agents with high tumor uptake and excellent tumor/non-target ratios, a glucose derivative containing cyclohexane (CNMCHDG) was synthesized and labeled with Tc-99m.
Junhong Feng, Xuran Zhang, Yuhao Jiang, Qing Ruan, Qianna Wang, Junbo Zhang   +5 more
doaj   +1 more source

Comparison of regional flortaucipir PET with quantitative tau immunohistochemistry in three subjects with Alzheimer’s disease pathology: a clinicopathological study

EJNMMI Research, 2020
Background The objective of this study was to make a quantitative comparison of flortaucipir PET retention with pathological tau and β-amyloid across a range of brain regions at autopsy.
Michael J. Pontecorvo, C. Dirk Keene, Thomas G. Beach, Thomas J. Montine, Anupa K. Arora, Michael D. Devous, Michael Navitsky, Ian Kennedy, Abhinay D. Joshi, Ming Lu, Geidy E. Serrano, Lucia I. Sue, Anthony J. Intorcia, Shannon E. Rose, Angela Wilson, Leanne Hellstern, Natalie Coleman, Matthew Flitter, Patricia Aldea, Adam S. Fleisher, Mark A. Mintun, Andrew Siderowf   +21 more
doaj   +1 more source

Radiolabeling and Biological Evaluation of Novel ^99mTc-Nitrido and ^99mTc-Oxo Complexes with 4-Methoxy-_L-Phenylalanine Dithiocarbamate for Tumor Imaging

Pharmaceutics, 2022
To develop novel radiolabeled amino acid tumor imaging agents, 4-methoxy-L-phenylalanine dithiocarbamate (MOPADTC) was synthesized successfully, and two kinds of 99mTc-labeled complexes ([99mTc]TcN-MOPADTC and [99mTc]TcO-MOPADTC) with high radiochemical ...
Guangxing Yin, Qing Ruan, Yuhao Jiang, Junbo Zhang   +3 more
doaj   +1 more source

Hydroxypyridinones as a Very Promising Platform for Targeted Diagnostic and Therapeutic Radiopharmaceuticals

Molecules, 2021
Hydroxypyridinones (HOPOs) have been used in the chelation therapy of iron and actinide metals. Their application in metal-based radiopharmaceuticals has also been increasing in recent years.
Xu Zhou, Linlin Dong, Langtao Shen
doaj   +1 more source

Synthesis and Evaluation of Novel Norfloxacin Isonitrile ^99mTc Complexes as Potential Bacterial Infection Imaging Agents

Pharmaceutics, 2021
To develop potential technetium-99m single-photon emission computed tomography (SPECT) imaging agents for bacterial infection imaging, the novel norfloxacin isonitrile derivatives CN4NF and CN5NF were synthesized and radiolabeled with a [99mTc][Tc(I ...
Si’an Fang, Yuhao Jiang, Di Xiao, Xuran Zhang, Qianqian Gan, Qing Ruan, Junbo Zhang   +6 more
doaj   +1 more source