Results 11 to 20 of about 78,818 (344)

The Radiobiology of Radiopharmaceuticals.

Seminars in Radiation Oncology, 2021
Radiopharmaceutical therapy or targeted radionuclide therapy (TRT) is a well-established class of cancer therapeutics that includes a growing number of FDA-approved drugs and a promising pipeline of experimental therapeutics. Radiobiology is fundamental to a mechanistic understanding of the therapeutic capacity of these agents and their potential ...
Z. Morris, Andrew Z. Wang, S. Knox
semanticscholar   +4 more sources

Analysis of Radiopharmaceuticals [PDF]

Journal of AOAC INTERNATIONAL, 1971
Abstract Some of the activities of chemists engaged in evaluating and selecting analytical methodology for examination of radiopharmaceuticals and the criteria for assessment of their quality are described. Significant problems, as they relate to a regulatory analysis program, and tentative solutions to these problems are discussed ...
Max Jaffee, Leonard A. Ford
openalex   +3 more sources

Therapy with Radiopharmaceuticals [PDF]

Acta Oncologica, 2002
In an investigation by the Swedish Cancer Society, an expert group described the present status, critical issues and future aspects and potentials for each of nine major areas of radiation therapy research. The present report deals with therapy with radiopharmaceuticals.
Jörgen, Carlsson, Eva, Forssell-Aronsson, Bengt, Glimelius, Sören, Mattsson, The, Swedish Cancer Society Investigation Group   +4 more
openaire   +3 more sources

The Chemical Scaffold of Theranostic Radiopharmaceuticals: Radionuclide, Bifunctional Chelator, and Pharmacokinetics Modifying Linker

Molecules, 2022
Therapeutic radiopharmaceuticals have been researched extensively in the last decade as a result of the growing research interest in personalized medicine to improve diagnostic accuracy and intensify intensive therapy while limiting side effects ...
H. A. Holik, F. Ibrahim, Angela Alysia Elaine, Bernap Dwi Putra, Arifudin Achmad, A. Kartamihardja   +5 more
semanticscholar   +1 more source

Radiolabeling and Biological Evaluation of Novel ^99mTc-Nitrido and ^99mTc-Oxo Complexes with 4-Methoxy-_L-Phenylalanine Dithiocarbamate for Tumor Imaging

Pharmaceutics, 2022
To develop novel radiolabeled amino acid tumor imaging agents, 4-methoxy-L-phenylalanine dithiocarbamate (MOPADTC) was synthesized successfully, and two kinds of 99mTc-labeled complexes ([99mTc]TcN-MOPADTC and [99mTc]TcO-MOPADTC) with high radiochemical ...
Guangxing Yin, Qing Ruan, Yuhao Jiang, Junbo Zhang   +3 more
doaj   +1 more source

Cold Kit Labeling: The Future of 68Ga Radiopharmaceuticals?

Frontiers in Medicine, 2022
Over the last couple of decades, gallium-68 (68Ga) has gained a formidable interest for PET molecular imaging of various conditions, from cancer to infection, through cardiac pathologies or neuropathies.
N. Lepareur
semanticscholar   +1 more source

Comparison of regional flortaucipir PET with quantitative tau immunohistochemistry in three subjects with Alzheimer’s disease pathology: a clinicopathological study

EJNMMI Research, 2020
Background The objective of this study was to make a quantitative comparison of flortaucipir PET retention with pathological tau and β-amyloid across a range of brain regions at autopsy.
Michael J. Pontecorvo, C. Dirk Keene, Thomas G. Beach, Thomas J. Montine, Anupa K. Arora, Michael D. Devous, Michael Navitsky, Ian Kennedy, Abhinay D. Joshi, Ming Lu, Geidy E. Serrano, Lucia I. Sue, Anthony J. Intorcia, Shannon E. Rose, Angela Wilson, Leanne Hellstern, Natalie Coleman, Matthew Flitter, Patricia Aldea, Adam S. Fleisher, Mark A. Mintun, Andrew Siderowf   +21 more
doaj   +1 more source

Preparation and Bioevaluation of a Novel ^99mTc-Labeled Glucose Derivative Containing Cyclohexane as a Promising Tumor Imaging Agent

Pharmaceuticals, 2023
To develop novel tumor imaging agents with high tumor uptake and excellent tumor/non-target ratios, a glucose derivative containing cyclohexane (CNMCHDG) was synthesized and labeled with Tc-99m.
Junhong Feng, Xuran Zhang, Yuhao Jiang, Qing Ruan, Qianna Wang, Junbo Zhang   +5 more
doaj   +1 more source

Development of radiopharmaceuticals for targeted alpha therapy: Where do we stand?

Frontiers in Medicine, 2022
Targeted alpha therapy is an oncological treatment, where cytotoxic doses of alpha radiation are locally delivered to tumor cells, while the surrounding healthy tissue is minimally affected.
R. M. Pallares, R. Abergel
semanticscholar   +1 more source

Current use and future potential of (physiologically based) pharmacokinetic modelling of radiopharmaceuticals: a review

Theranostics, 2022
Rationale: Physiologically based pharmacokinetic (PBPK) and population pharmacokinetic (PK) modelling approaches are widely accepted in non-radiopharmaceutical drug development and research, while there is no major role for these approaches in ...
H. Siebinga, B. J. de Wit-van der Veen, M. D. Stokkel, A. Huitema, J. Hendrikx   +4 more
semanticscholar   +1 more source