Results 21 to 30 of about 78,818 (344)

Practical considerations for navigating the regulatory landscape of non-clinical studies for clinical translation of radiopharmaceuticals

EJNMMI Radiopharmacy and Chemistry, 2022
Background The development of radiopharmaceuticals requires extensive evaluation before they can be applied in a diagnostic or therapeutic setting in Nuclear Medicine.
A. Korde, R. Mikołajczak, Petra Kolenc, P. Bouziotis, Hadis Westin, Mette Lauritzen, M. Koole, M. Herth, M. Bardiès, Andre F. Martins, A. Paulo, S. Lyashchenko, S. Todde, S. Nag, Efthimis Lamprou, A. Abrunhosa, F. Giammarile, C. Decristoforo   +17 more
semanticscholar   +1 more source

Hydroxypyridinones as a Very Promising Platform for Targeted Diagnostic and Therapeutic Radiopharmaceuticals

Molecules, 2021
Hydroxypyridinones (HOPOs) have been used in the chelation therapy of iron and actinide metals. Their application in metal-based radiopharmaceuticals has also been increasing in recent years.
Xu Zhou, Linlin Dong, Langtao Shen
doaj   +1 more source

Radiolabeling and quality control of therapeutic radiopharmaceuticals: optimization, clinical implementation and comparison of radio-TLC/HPLC analysis, demonstrated by [177Lu]Lu-PSMA

EJNMMI Radiopharmacy and Chemistry, 2022
Background Radiopharmaceuticals are considered as regular medicinal products and therefore the same regulations as for non-radioactive medicinal products apply.
Eline L. Hooijman, Carolline M Ntihabose, Thom G A Reuvers, J. Nonnekens, E. A. Aalbersberg, Jordy R. J. P. van de Merbel, Judith E. Huijmans, Stijn L W Koolen, J. Hendrikx, E. de Blois   +9 more
semanticscholar   +1 more source

Synthesis and Evaluation of Novel Norfloxacin Isonitrile ^99mTc Complexes as Potential Bacterial Infection Imaging Agents

Pharmaceutics, 2021
To develop potential technetium-99m single-photon emission computed tomography (SPECT) imaging agents for bacterial infection imaging, the novel norfloxacin isonitrile derivatives CN4NF and CN5NF were synthesized and radiolabeled with a [99mTc][Tc(I ...
Si’an Fang, Yuhao Jiang, Di Xiao, Xuran Zhang, Qianqian Gan, Qing Ruan, Junbo Zhang   +6 more
doaj   +1 more source

Adverse reactions to radiopharmaceuticals [PDF]

Farmacia Hospitalaria, 2021
Spanish Royal Legislative Decree 1/2015 of July 24 considered radiopharmaceuticals to be drugs subject to current legislation on this matter. After Radiopharmaceuticals are prepared in Radiopharmacy Departments, they are administered to patients to ...
María del Val Gómez-Martínez, Marta Soler-Vigil, Carla de Gracia-Rodríguez, Purificación Pastor-Fructuoso, Juan Antonio Pérez-Iruela   +4 more
doaj   +1 more source

Albumin Binder–Conjugated Fibroblast Activation Protein Inhibitor Radiopharmaceuticals for Cancer Therapy

Journal of Nuclear Medicine, 2021
Visual Abstract Fibroblast activation protein (FAP) has become an attractive target for diagnosis and therapy, and a series of FAP inhibitor (FAPI)–based radiotracers has been developed and had excellent performance for diagnosis outcomes in clinical ...
Mengxin Xu, Pu Zhang, J. Ding, Junyi Chen, L. Huo, Zhibo Liu   +5 more
semanticscholar   +1 more source

Guideline on current good radiopharmacy practice (cGRPP) for the small-scale preparation of radiopharmaceuticals

EJNMMI Radiopharmacy and Chemistry, 2021
This guideline on current good radiopharmacy practice (cGRPP) for small-scale preparation of radiopharmaceuticals represents the view of the Radiopharmacy Committee of the European Association of Nuclear Medicine (EANM).
N. Gillings, Olaug Hjelstuen, J. Ballinger, M. Béhé, C. Decristoforo, P. Elsinga, Valentina Ferrari, P. Peitl, J. Koziorowski, P. Laverman, T. Mindt, Oliver Neels, M. Ocak, M. Patt, S. Todde   +14 more
semanticscholar   +1 more source

Expanding Theranostic Radiopharmaceuticals for Tumor Diagnosis and Therapy

Pharmaceuticals, 2021
Radioligand theranostics (RT) in oncology use cancer-type specific biomarkers and molecular imaging (MI), including positron emission tomography (PET), single-photon emission computed tomography (SPECT) and planar scintigraphy, for patient diagnosis ...
Cristina Barca, C. Griessinger, A. Faust, D. Depke, M. Essler, A. Windhorst, N. Devoogdt, K. Brindle, M. Schäfers, B. Zinnhardt, A. Jacobs   +10 more
semanticscholar   +1 more source

Future Prospective of Radiopharmaceuticals from Natural Compounds Using Iodine Radioisotopes as Theranostic Agents

Molecules, 2022
Natural compounds provide precursors with various pharmacological activities and play an important role in discovering new chemical entities, including radiopharmaceuticals.
Wiwit Nurhidayah, Luthfi Utami Setyawati, Isti Daruwati, Amirah Mohd Gazzali, Toto Subroto, Muchtaridi Muchtaridi   +5 more
doaj   +1 more source

Nuclear medicine procedures and the evaluation of male sexual organs: a short review [PDF]

, 2008
Sexuality consists of three aspects that are interrelated and inseparable, biological, physiological and social. The biological aspect considers the individual's capability to give and to receive pleasure.
Adenilson de Souza da Fonseca, Bernardo-Filho M., Beutel M. E., Bouchelouche K., Chaffanjon P. C., Choe W., Dennerstein L., Fanti S., Ganjoo K. N., Gerber G., Halac M., Hatzimouratidis H., Jana S., Kevin Carter, Kim C. K., Kolodny R. C., Kotzerke J., Kotzerke J., Kumar V., Lange P. H., Mario Bernardo-Filho, Masters W. H., Orhan I., Perkins A., Perkins A., Ravizzini G., Roivainen A., Ryu J., Saha G., Sebastião David Santos-Filho, Shen Y. Y., Sotiris Missailidis, Stelzner F., Sumich A. L., Timmermans L., Tóth G., Valdés Olmos R. A., Warren G. P., Willan B. D., Zuckier L. S.   +39 more
core   +4 more sources