Results 81 to 90 of about 78,818 (344)

Coronary Flow Reserve Measured by Myocardial Perfusion Imaging in Patients Following Percutaneous Coronary Intervention

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Despite achieving complete revascularization, patients with coronary artery disease (CAD) may experience adverse outcomes, potentially attributable to coronary microvascular dysfunction (CMD). Coronary flow reserve (CFR), which integrates both epicardial and microvascular coronary function, and a reduced CFR following complete ...
Jingjing Liu, Jian Zhang, Wenhua Lin, Yuming Li   +3 more
wiley   +1 more source

Preclinical evaluation of [18F]FP-CIT, the radiotracer targeting dopamine transporter for diagnosing Parkinson’s disease: pharmacokinetic and efficacy analysis

EJNMMI Research
Background N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane (FP-CIT), the representative cocaine derivative used in dopamine transporter imaging, is a promising biomarker, as it reflects the severity of Parkinson’s disease (PD).
Jae Hun Ahn, Min Hwan Kim, Kyongkyu Lee, Keumrok Oh, Hyunwoo Lim, Hee Seup Kil, Soon Jeong Kwon, Jae Yong Choi, Dae Yoon Chi, Yong Jin Lee   +9 more
doaj   +1 more source

Nuclear medicine in endocrine tumours [PDF]

, 2011
C
Peremans, Kathelijne, Van De Wiele, Christophe   +1 more
core   +2 more sources

Palliative treatment of metastatic bone pain with radiopharmaceuticals: a perspective beyond Strontium-89 and Samarium-153 [PDF]

, 2016
PurposeThe present review article aims to provide an overview of the available radionuclides for palliative treatment of bone metastases beyond 89Sr and 153Sm.
Adriana Alexandre S. Tavares, Francisco D. C. Guerra Liberal, João Manuel R. S. Tavares   +2 more
core   +1 more source

Substitution of CH3 by CH2F in 2‐Methylerythritol Cyclodiphosphate Triggers Potent Inhibition of IspG with Concomitant Fluoride Ion Expulsion

Chemistry – A European Journal, EarlyView.
The fluoromethyl analogue of MEcPP was identified as a very potent inhibitor of the oxygen‐sensitive [4Fe‐4S] metalloenzyme IspG. In the course of the IspG‐catalyzed transformation, this novel compound undergoes fluoride elimination, offering additional evidence for the involvement of a carbanionic intermediate in the mechanism of this enzyme ...
Clea Witjaksono, Vivien Herrscher, Hannah Jobelius, Nathan Noël, Fabien Massicot, Jean‐Luc Vasse, Jean‐Bernard Behr, Myriam Seemann   +7 more
wiley   +1 more source

Carbon dots: An innovative luminescent nanomaterial

Aggregate, 2022
In recent years, carbon dots (CDs), including carbon nanodots, carbonized polymer dots, carbon quantum dots, and graphene quantum dots have attracted a mounting interest as readily accessible, nontoxic, and relatively inexpensive carbon‐based ...
Yuxin Shi, Huimin Xu, Ting Yuan, Ting Meng, Hao Wu, Jianqiao Chang, Haoyu Wang, Xianzhi Song, Yunchao Li, Xiaohong Li, Yang Zhang, Wenjing Xie, Louzhen Fan   +12 more
doaj   +1 more source

Letter: Radiopharmaceuticals in breastfeeding [PDF]

Australian Prescriber, 2016
In the article on drugs in breastfeeding,1 I was dismayed at the inclusion of ‘radiopharmaceuticals’ in the table of drugs contraindicated in breastfeeding. There was little elaboration within the article as to the reason for this. The other drugs listed have sufficient evidence of the potential for serious adverse effects to the infant.
openaire   +3 more sources

Re‐Evaluation of Fixed Dosing Versus Body Size‐Based Dosing Approaches for Large Molecule Therapeutics in Adults

Clinical Pharmacology &Therapeutics, EarlyView.
Wang et al.1 (2009) and Zhang et al.2 (2011) recommended a fixed dosing approach for large molecule therapeutics for first‐in‐human (FIH) trials, based on the finding that the majority of α values (body size effect on clearance) were < 0.5 across 12 monoclonal antibodies (mAbs) and 18 therapeutic proteins (TPs) and peptides, and fixed dosing provides ...
Andrew B. SyBing, Huili Chen, Diane D. Wang   +2 more
wiley   +1 more source

Comparison of high-specific-activity ultratrace 123/131I-MIBG and carrier-added 123/131I-MIBG on efficacy, pharmacokinetics, and tissue distribution [PDF]

, 2010
Metaiodobenzylguanidine (MIBG) is an enzymatically stable synthetic analog of norepinephrine that when radiolabled with diagnostic ((123)I) or therapeutic ((131)I) isotopes has been shown to concentrate highly in sympathetically innervated tissues such ...
Babich, John W, Barrett, John A, Boyd, Marie, Femia, Frank J, Hillier, Shawn M, Joyal, John L, Kronauge, James F, Mairs, Robert J, Maresca, Kevin P   +8 more
core   +1 more source

Seminars in epileptology: Presurgical epilepsy evaluation

Epileptic Disorders, EarlyView.
Abstract All patients with drug‐resistant seizures benefit from a comprehensive evaluation to confirm their seizure diagnosis and explore surgical treatment options. This seminar in epileptology discusses advancements in the field and provides specific didactic material to create an active working knowledge for the care of patients with focal drug ...
Stephan Schuele, Robyn M. Busch, Birgit Frauscher, Vadym Gnatkovsky, Hajo Hamer, Lara Jehi, Andres Kanner, Georgia Ramantani, Theodor Rüber, Andreas Schulze‐Bonhage, Rainer Surges, Lara Wadi   +11 more
wiley   +1 more source