Results 51 to 60 of about 14,471 (229)

Effect of Functional Inhibition of BACE1 on Sensitization to γ-Irradiation in Cancer Cells

Current Issues in Molecular Biology
Developing strategies for the radiosensitization of cancer cells by the inhibition of genes, which harbor low toxicity to normal cells, will be useful for improving cancer radiotherapy.
Keitaro Nakamoto, Sota Kikuhara, Hiroaki Fujimori, Barkha Saraswat, Zhongming Gao, Ankitha Vadi Velu, Zongxiang Zhang, Ying Tong, Shoji Imamichi, Tadashige Nozaki, Yasufumi Murakami, Mitsuko Masutani   +11 more
doaj   +1 more source

Dissecting the Radioresponse Heterogeneity of Lung Adenocarcinoma Cells From the Perspective of Transcriptional and Regulatory Landscape. [PDF]

MedComm (2020)
Radiation‐associated transcriptional and regulatory cell states drive heterogeneous radioresponses in isogenic lung adenocarcinoma cells. ABSTRACT Radioresistance severely compromises radiotherapy efficacy for lung adenocarcinoma (LUAD), yet the intrinsic heterogeneity of cellular radioresponses among isogenic tumor cells remains poorly characterized ...
Tao H, Li Y, Ge L, Chen L, Zheng Y, Ma F, Ge C, Fu H, Sun Y, Wang L, Wang J, Bai X, Li H, Bo X, Chen H, Zheng X.   +15 more
europepmc   +2 more sources

Amcinonide Exhibits Antitumor Effects in Radioresistant Colorectal Cancer Through the circRNF10/miR‐296‐5p/Snail Axis

Advanced Science, EarlyView.
Amcinonide (AMC), the FDA‐approved corticosteroid, was identified as a repurposed agent for radiation‐resistant colorectal cancer. AMC suppresses radiation‐induced epithelial–mesenchymal transition, migration, and invasion via the circRNF10/miR‐296‐5p/Snail axis.
Hyun Jeong Seok, Dong Hyeon Lee, Junhye Kwon, Ui Sup Shin, In Hwa Bae   +4 more
wiley   +1 more source

Correction: Dependence of gold nanoparticle radiosensitization on cell geometry

, 2017
Correction for ‘Dependence of gold nanoparticle radiosensitization on cell geometry’ by Wonmo Sung, et al., Nanoscale, 2017, 9, 5843–5853.
Stephen J. McMahon, Harald Paganetti, Henry M. Smilowitz, Sung-Joon Ye, James Hainfeld, Aimee L. McNamara, Jungwook Shin, Jan Schuemann, Wonmo Sung   +8 more
core   +1 more source

End-joining deficiency and radiosensitization induced by gemcitabine

, 2001
The mechanism of radiosensitization by gemcitabine (2',2'-dinuoro-2'-deoxycytidine, dFdC) is not exactly known. We investigated the possible role of inhibition of the repair of DNA double-strand breaks by dFdC by measuring the extent of ...
Kampinga, HH; id_orcid, Groea, HJM, Smid, K, van Putten, JWG, Peters, GJ   +4 more
core   +1 more source

DTX3 Suppresses the NPM3–RUVBL1 Axis to Inhibit Homologous Recombination Repair and Abrogate Tumor Radioresistance

Advanced Science, EarlyView.
Deltex 3 (DTX3) catalyzes K27‐linked ubiquitination of nucleophosmin 3 to disrupt homologous recombination repair and reverse tumor radioresistance. Low DTX3 predicts poor survival and radiotherapy recurrence, serving as a radiosensitizing therapeutic target.
Jia‐Hao Xiao, Chang‐Jun Xie, Yan‐Hua Chen, Hao Cheng, Shuang‐Hui Li, Wei Li, Ya‐Wen Bin, Rui‐Min He, Ying‐Qing Li, Ping Feng   +9 more
wiley   +1 more source

Supplementary Fig. S2 from Radiosensitization of solid tumors by Z-VAD, a pan-caspase inhibitor

, 2009
Supplementary Fig.
Dae Kwang Jung (15042008), Luigi Moretti (377640), Bo Lu (241075), Christopher D. Willey (8463099), Kwang Woon Kim (15042005)   +4 more
core   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Supplementary Data from Radiosensitization by the Histone Deacetylase Inhibitor PCI-24781

, 2007
Supplementary Data from Radiosensitization by the Histone Deacetylase Inhibitor PCI ...
Carmen A. Banuelos (636867), Judit P. Banáth (14973756), Jin Zhao (94790), Tarren Reitsema (14974747), Susan H. MacPhail (14974744), Peggy L. Olive (14973762)   +5 more
core   +1 more source

Combined 2-deoxy glucose and metformin improves therapeutic efficacy of sodium-iodide symporter-mediated targeted radioiodine therapy in breast cancer cells

Breast Cancer: Targets and Therapy, 2015
Sushmita Chatterjee, Nirmal Thaker, Abhijit DeMolecular Functional Imaging Laboratory, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, IndiaAbstract: Radiosensitization using either metformin ...
Chatterjee S, Thaker N, De A
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