Results 31 to 40 of about 14,471 (229)

A Guide for Using Transmission Electron Microscopy for Studying the Radiosensitizing Effects of Gold Nanoparticles In Vitro

Nanomaterials, 2021
The combined effects of ionizing radiation (IR) with high-z metallic nanoparticles (NPs) such as gold has developed a growing interest over the recent years.
Ioanna Tremi, Sophia Havaki, Sofia Georgitsopoulou, Nefeli Lagopati, Vasilios Georgakilas, Vassilis G. Gorgoulis, Alexandros G. Georgakilas   +6 more
doaj   +1 more source

Oncogenic K-Ras Signals through Epidermal Growth Factor Receptor and Wild-Type H-Ras to Promote Radiation Survival in Pancreatic and Colorectal Carcinoma Cells

Neoplasia: An International Journal for Oncology Research, 2007
Pancreatic and colorectal carcinomas frequently express oncogenic/mutant K-Ras that contributes to both tumorigenesis and clinically observed resistance to radiation treatment.
Keith A. Cengel, K. Rahn Voong, Sanjay Chandrasekaran, Laurence Maggiorella, Thomas B. Brunner, Eric Stanbridge, Gary D. Kao, W. Gillies McKenna, Eric J. Bernhard   +8 more
doaj   +1 more source

A New Generation of Ultrasmall Nanoparticles Inducing Sensitization to Irradiation and Copper Depletion to Overcome Radioresistant and Invasive Cancers

Pharmaceutics, 2022
An emerging target to overcome cancer resistance to treatments is copper, which is upregulated in a wide variety of tumors and may be associated with cancer progression and metastases.
Paul Rocchi, Delphine Brichart-Vernos, François Lux, Isabelle Morfin, Laurent David, Claire Rodriguez-Lafrasse, Olivier Tillement   +6 more
doaj   +1 more source

Cell‐Based Biohybrid Micro/Nanorobots for Biotherapy

Advanced Robotics Research, EarlyView.
This review systematically evaluates cell‐based biohybrid micro/nanorobots (CB‐BMRs), highlighting their cell selection criteria, fabrication strategies, and diverse actuation modes. Furthermore, it surveys the promising therapeutic applications of CB‐BMRs in targeted cancer, thrombosis, and inflammation treatments, while comprehensively discussing ...
Lin Wang, Chenlu Liu, Yu Zhao, Chuanhua Li, Xuyang Chen, Shixiao Ding, Lizhou Dai, Guokun Wang, Tianlong Li, Jiaxin Li, Xuejia Liu, Haocheng Wang   +11 more
wiley   +1 more source

PARP inhibitor olaparib sensitizes cholangiocarcinoma cells to radiation

Cancer Medicine, 2018
Cholangiocarcinoma (CCA) is a highly malignant tumor with resistance to radiotherapy alone. Olaparib, a highly potent poly(ADP‐ribose) polymerase (PARP) inhibitor, has been shown to sensitize many types of tumor to radiotherapy.
Yize Mao, Xin Huang, Zeyu Shuang, Guohe Lin, Jun Wang, Fangting Duan, Jianlin Chen, Shengping Li   +7 more
doaj   +1 more source

Radiosensitization effects and ROS generation by high Z metallic nanoparticles on human colon carcinoma cell (HCT116) irradiated under 150 MeV proton beam

OpenNano, 2019
Radiosensitization effects caused by high atomic number (Z) metallic nanoparticles have been extensively explored with a wide range of X-ray based radiotherapy beams that seem to provide intriguing results for potential clinical applications.
Raizulnasuha Abdul Rashid, Safri Zainal Abidin, Muhammad Afiq Khairil Anuar, Takahiro Tominaga, Hiroaki Akasaka, Ryohei Sasaki, Katahira Kie, Khairunisak Abdul Razak, Binh. T.T. Pham, Brian S. Hawkett, Mary-Ann Carmichael, Moshi Geso, Wan Nordiana Rahman   +12 more
doaj   +1 more source

An Activity‐Reinforced P‐Modified Single‐Atom Cu Nanozyme Potentiates IDO Blockade‐Induced Tumor Radiotherapy

Advanced Science, EarlyView.
A phosphorus‐modified single‐atom copper nanozyme delivering the IDO1 inhibitor 1‐methyl‐tryptophan enhances breast cancer radioimmunotherapy by simultaneously relieving hypoxia and inducing immunogenic cell death through dual enzyme activities while blocking tryptophan metabolism to suppress regulatory T cell function.
Wei Zhao, Songliu Hu, Zhanggui Wang, Liqun Wang, Liming Zhang, Qi Li, Hua Tang, Yang Zhong, Zhongxian Zhang, Kelong Fan, Shipeng Ning, Xiyun Yan   +11 more
wiley   +1 more source

In vitro radiosensitization by eribulin in human cancer cell lines [PDF]

, 2022
Background: The Objective was to to determine the radiosensitizing properties of eribulin and the potential mechanisms of radiosensitization in cervical (HeLa) and pharyngeal (FaDu) cancer cell lines.
Castejón, Raquel; Medicina Interna, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana (IDIPHISA), Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain, Romero, Jesús; Servicio de Oncología Radioterápica, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain, Coronado, María José; Unidad de Microscopía Confocal, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana (IDIPHISA), Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain, Benlloch, Raquel; Servicio de Oncología Radioterápica, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain, Rosado, Silvia; Unidad de Cultivos Celulares, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana (IDIPHISA), Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain, Sánchez, Patricia; Servicio de Radiofísica, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain, Rosado, Silvia, Coronado, María José, Benlloch, Raquel, Castejón, Raquel, Sánchez, Patricia, Romero, Jesús, Silvia Rosado, María José Coronado, Jesús Romero, Raquel Castejón, Raquel Benlloch, Patricia Sánchez   +17 more
core   +1 more source

Boosted Radiation Bystander Effect of PSMA-Targeted Gold Nanoparticles in Prostate Cancer Radiosensitization

Nanomaterials, 2022
Metal nanoparticles are effective radiosensitizers that locally enhance radiation doses in targeted cancer cells. Compared with other metal nanoparticles, gold nanoparticles (GNPs) exhibit high biocompatibility, low toxicity, and they increase secondary ...
Daiki Hara, Wensi Tao, Ryder M. Schmidt, Yu-Ping Yang, Sylvia Daunert, Nesrin Dogan, John Chetley Ford, Alan Pollack, Junwei Shi   +8 more
doaj   +1 more source

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source